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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 353

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Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.
Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA
(2016) Cancer Prev Res (Phila) 9: 855-865
MeSH Terms: Adenocarcinoma, Adult, Aspirin, Cell Line, Tumor, Cyclooxygenase 2, Cyclooxygenase Inhibitors, Dinoprostone, Female, Humans, Male, Neoplasm Invasiveness
Added January 29, 2018
0 Communities
2 Members
0 Resources
11 MeSH Terms
Assay of Endocannabinoid Oxidation by Cyclooxygenase-2.
Kudalkar SN, Kingsley PJ, Marnett LJ
(2016) Methods Mol Biol 1412: 205-15
MeSH Terms: Animals, Arachidonic Acid, Arachidonic Acids, Biological Assay, Cell Line, Chromatography, Liquid, Cyclooxygenase 2, Endocannabinoids, Glycerides, In Vitro Techniques, Macrophages, Mice, Oxidation-Reduction, Polyunsaturated Alkamides, Substrate Specificity, Tandem Mass Spectrometry
Added April 22, 2018
0 Communities
2 Members
0 Resources
MeSH Terms
Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.
Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S
(2016) Elife 5:
MeSH Terms: Animals, Basolateral Nuclear Complex, Behavior, Animal, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Mice, Stress, Physiological
Added March 14, 2018
0 Communities
2 Members
0 Resources
7 MeSH Terms
Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer.
Uddin MJ, Werfel TA, Crews BC, Gupta MK, Kavanaugh TE, Kingsley PJ, Boyd K, Marnett LJ, Duvall CL
(2016) Biomaterials 92: 71-80
MeSH Terms: Animals, Cell Line, Tumor, Cyclooxygenase 2, Dynamic Light Scattering, Female, Humans, Indoles, Inflammation, Injections, Intraperitoneal, Mice, Inbred C57BL, Mice, Nude, Molecular Imaging, Nanoparticles, Neoplasms, Polymers, Rhodamines, Tissue Distribution
Added March 14, 2018
0 Communities
3 Members
0 Resources
17 MeSH Terms
Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma.
Cook PJ, Thomas R, Kingsley PJ, Shimizu F, Montrose DC, Marnett LJ, Tabar VS, Dannenberg AJ, Benezra R
(2016) Neuro Oncol 18: 1379-89
MeSH Terms: Animals, Blotting, Western, Brain Neoplasms, Chromatin Immunoprecipitation, Cyclooxygenase 2, Dinoprostone, Enzyme-Linked Immunosorbent Assay, Gene Knockdown Techniques, Glioblastoma, Humans, Immunohistochemistry, Inhibitor of Differentiation Protein 1, Mice, Radiation Tolerance, Real-Time Polymerase Chain Reaction, Signal Transduction
Added April 12, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.
Konkle ME, Blobaum AL, Moth CW, Prusakiewicz JJ, Xu S, Ghebreselasie K, Akingbade D, Jacobs AT, Rouzer CA, Lybrand TP, Marnett LJ
(2016) Biochemistry 55: 348-59
MeSH Terms: Amides, Computational Biology, Cyclooxygenase 2, Enzyme Activation, Esters, Indomethacin, Protein Structure, Secondary, Structure-Activity Relationship
Added February 22, 2016
0 Communities
2 Members
0 Resources
8 MeSH Terms
Competition and allostery govern substrate selectivity of cyclooxygenase-2.
Mitchener MM, Hermanson DJ, Shockley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ
(2015) Proc Natl Acad Sci U S A 112: 12366-71
MeSH Terms: Algorithms, Allosteric Regulation, Allosteric Site, Animals, Arachidonic Acid, Arachidonic Acids, Binding, Competitive, Catalytic Domain, Cell Line, Computer Simulation, Cyclooxygenase 2, Endocannabinoids, Glycerides, Kinetics, Macrophages, Mice, Oxidation-Reduction, Prostaglandins, Protein Binding, Protein Multimerization, Sf9 Cells, Spodoptera, Substrate Specificity, Zymosan
Added February 15, 2016
1 Communities
4 Members
0 Resources
24 MeSH Terms
Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.
Chang J, Vacher J, Yao B, Fan X, Zhang B, Harris RC, Zhang MZ
(2015) Oncotarget 6: 33500-11
MeSH Terms: Animals, Carcinogenesis, Colorectal Neoplasms, Cyclooxygenase 2, Disease Models, Animal, Female, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myeloid Cells, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RAW 264.7 Cells, Receptors, Prostaglandin E, EP4 Subtype, TOR Serine-Threonine Kinases
Added May 5, 2017
1 Communities
0 Members
0 Resources
17 MeSH Terms
nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.
Neumann W, Xu S, Sárosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins E
(2016) ChemMedChem 11: 175-8
MeSH Terms: Animals, Binding Sites, Boranes, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Indomethacin, Mice, Models, Molecular, Molecular Structure, Sheep, Solubility, Structure-Activity Relationship
Added February 22, 2016
0 Communities
2 Members
0 Resources
13 MeSH Terms
Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways.
Chang J, Xue M, Yang S, Yao B, Zhang B, Chen X, Pozzi A, Zhang MZ
(2015) PLoS One 10: e0127030
MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenases, Animals, Apoptosis, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Corticosterone, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Endoplasmic Reticulum Stress, Extracellular Signal-Regulated MAP Kinases, Glycyrrhetinic Acid, Humans, Lung Neoplasms, Male, Mice, Inbred C57BL, Models, Biological, Signal Transduction, TOR Serine-Threonine Kinases
Added October 30, 2016
1 Communities
0 Members
0 Resources
19 MeSH Terms