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Results: 11 to 20 of 65

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Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S, Khan S, Maranian MJ, O'Reilly M, Hillman KM, Betts JA, Carroll T, Bailey PJ, Dicks E, Beesley J, Tyrer J, Maia AT, Beck A, Knoblauch NW, Chen C, Kraft P, Barnes D, González-Neira A, Alonso MR, Herrero D, Tessier DC, Vincent D, Bacot F, Luccarini C, Baynes C, Conroy D, Dennis J, Bolla MK, Wang Q, Hopper JL, Southey MC, Schmidt MK, Broeks A, Verhoef S, Cornelissen S, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Fasching PA, Loehberg CR, Ekici AB, Beckmann MW, Peto J, dos Santos Silva I, Johnson N, Aitken Z, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Guénel P, Truong T, Laurent-Puig P, Menegaux F, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Milne RL, Zamora MP, Arias Perez JI, Benitez J, Anton-Culver H, Brenner H, Müller H, Arndt V, Stegmaier C, Meindl A, Lichtner P, Schmutzler RK, Engel C, Brauch H, Hamann U, Justenhoven C, GENICA Network, Aaltonen K, Heikkilä P, Aittomäki K, Blomqvist C, Matsuo K, Ito H, Iwata H, Sueta A, Bogdanova NV, Antonenkova NN, Dörk T, Lindblom A, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, kConFab Investigators, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Lambrechts D, Peeters S, Smeets A, Floris G, Chang-Claude J, Rudolph A, Nickels S, Flesch-Janys D, Radice P, Peterlongo P, Bonanni B, Sardella D, Couch FJ, Wang X, Pankratz VS, Lee A, Giles GG, Severi G, Baglietto L, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Simard J, Goldberg MS, Labrèche F, Dumont M, Teo SH, Yip CH, Ng CH, Vithana EN, Kristensen V, Zheng W, Deming-Halverson S, Shrubsole M, Long J, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Devilee P, Seynaeve C, García-Closas M, Figueroa J, Chanock SJ, Lissowska J, Czene K, Klevebring D, Schoof N, Hooning MJ, Martens JW, Collée JM, Tilanus-Linthorst M, Hall P, Li J, Liu J, Humphreys K, Shu XO, Lu W, Gao YT, Cai H, Cox A, Balasubramanian SP, Blot W, Signorello LB, Cai Q, Pharoah PD, Healey CS, Shah M, Pooley KA, Kang D, Yoo KY, Noh DY, Hartman M, Miao H, Sng JH, Sim X, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Sangrajrang S, Gaborieau V, McKay J, Toland AE, Ambrosone CB, Yannoukakos D, Godwin AK, Shen CY, Hsiung CN, Wu PE, Chen ST, Swerdlow A, Ashworth A, Orr N, Schoemaker MJ, Ponder BA, Nevanlinna H, Brown MA, Chenevix-Trench G, Easton DF, Dunning AM
(2013) Am J Hum Genet 92: 489-503
MeSH Terms: Binding Sites, Breast Neoplasms, Case-Control Studies, Cell Line, Tumor, Chromatin, Chromatin Immunoprecipitation, Chromosomes, Human, Pair 11, Cyclin D1, Electrophoretic Mobility Shift Assay, Enhancer Elements, Genetic, Female, GATA3 Transcription Factor, Gene Expression Regulation, Neoplastic, Humans, Luciferases, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, RNA, Messenger, RNA, Small Interfering, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Silencer Elements, Transcriptional, ets-Domain Protein Elk-4
Added March 10, 2014
0 Communities
2 Members
0 Resources
23 MeSH Terms
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.
Rai V, Touré F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM
(2012) J Exp Med 209: 2339-50
MeSH Terms: Animals, Cell Line, Tumor, Cyclin D1, Female, Humans, Lysophospholipids, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Muscle, Smooth, Vascular, Neoplasms, Proto-Oncogene Proteins c-akt, Rats, Receptor for Advanced Glycation End Products, Receptors, Immunologic, Recombinant Proteins, Signal Transduction
Added March 12, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.
Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J
(2012) PLoS One 7: e46624
MeSH Terms: Animals, Apoptosis, Blotting, Western, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Cyclin D1, Female, HeLa Cells, Histidine, Humans, Inhibitor of Apoptosis Proteins, Interleukin-6, Mice, Mice, SCID, Pancreatic Neoplasms, Phenylurea Compounds, Phosphorylation, Proto-Oncogene Proteins c-bcl-2, Reverse Transcriptase Polymerase Chain Reaction, STAT1 Transcription Factor, STAT3 Transcription Factor, Survivin
Added June 14, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina.
Das G, Clark AM, Levine EM
(2012) Dev Dyn 241: 941-52
MeSH Terms: Animals, Cell Cycle, Cell Differentiation, Cell Proliferation, Cyclin D1, Cyclin D2, Cyclin D3, Mice, Mice, Knockout, Retina, Stem Cells
Added November 2, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
RAF265 inhibits the growth of advanced human melanoma tumors.
Su Y, Vilgelm AE, Kelley MC, Hawkins OE, Liu Y, Boyd KL, Kantrow S, Splittgerber RC, Short SP, Sobolik T, Zaja-Milatovic S, Dahlman KB, Amiri KI, Jiang A, Lu P, Shyr Y, Stuart DD, Levy S, Sosman JA, Richmond A
(2012) Clin Cancer Res 18: 2184-98
MeSH Terms: Animals, Apoptosis, Base Sequence, Cell Cycle Proteins, Cell Proliferation, Cyclin D1, Extracellular Signal-Regulated MAP Kinases, Female, Gene Expression Profiling, Humans, Imidazoles, Ki-67 Antigen, MAP Kinase Signaling System, Male, Melanoma, Mice, Mice, Nude, Mutation, Oligonucleotide Array Sequence Analysis, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-kit, Proto-Oncogene Proteins p21(ras), Pyridines, Sequence Analysis, DNA, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, bcl-X Protein
Added June 14, 2013
2 Communities
11 Members
0 Resources
30 MeSH Terms
Mir-33 regulates cell proliferation and cell cycle progression.
Cirera-Salinas D, Pauta M, Allen RM, Salerno AG, Ramírez CM, Chamorro-Jorganes A, Wanschel AC, Lasuncion MA, Morales-Ruiz M, Suarez Y, Baldan Á, Esplugues E, Fernández-Hernando C
(2012) Cell Cycle 11: 922-33
MeSH Terms: Animals, Cell Line, Tumor, Cell Proliferation, Cyclin D1, Cyclin-Dependent Kinase 6, G1 Phase Cell Cycle Checkpoints, HeLa Cells, Humans, Liver Regeneration, Male, Mice, Mice, Inbred C57BL, MicroRNAs, Oligonucleotides, Antisense, Phosphates
Added February 12, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
Mittal MK, Singh K, Misra S, Chaudhuri G
(2011) J Biol Chem 286: 469-79
MeSH Terms: Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chromatin Assembly and Disassembly, Cyclin D1, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Humans, Neoplasm Invasiveness, Promoter Regions, Genetic, Proteasome Endopeptidase Complex, Snail Family Transcription Factors, Tamoxifen, Transcription Factors, Ubiquitin-Conjugating Enzymes, Ubiquitination
Added July 10, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
The PPARγ ligand ciglitazone regulates androgen receptor activation differently in androgen-dependent versus androgen-independent human prostate cancer cells.
Moss PE, Lyles BE, Stewart LV
(2010) Exp Cell Res 316: 3478-88
MeSH Terms: Androgen-Binding Protein, Cell Line, Tumor, Cell Proliferation, Cyclin D1, Dihydrotestosterone, Gene Expression, Genes, Reporter, Humans, Hypoglycemic Agents, Male, Mutation, Neoplasms, Hormone-Dependent, PPAR gamma, Prostate-Specific Antigen, Prostatic Neoplasms, RNA, Small Interfering, Receptors, Androgen, Rosiglitazone, Thiazolidinediones, Transfection
Added March 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer.
Vangamudi B, Peng DF, Cai Q, El-Rifai W, Zheng W, Belkhiri A
(2010) Mol Cancer 9: 240
MeSH Terms: Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Chromones, Cyclin D1, Dopamine and cAMP-Regulated Phosphoprotein 32, Female, Humans, Immunoblotting, Immunohistochemistry, Morpholines, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Polymerase Chain Reaction, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-myc, RNA, Small Interfering
Added March 5, 2014
0 Communities
4 Members
0 Resources
19 MeSH Terms
Cyclin D1b in human breast carcinoma and coexpression with cyclin D1a is associated with poor outcome.
Abramson VG, Troxel AB, Feldman M, Mies C, Wang Y, Sherman L, McNally S, Diehl A, Demichele A
(2010) Anticancer Res 30: 1279-85
MeSH Terms: Adult, Aged, Aged, 80 and over, Breast Neoplasms, Cohort Studies, Cyclin D1, Female, Follow-Up Studies, Humans, Immunohistochemistry, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Prospective Studies, Protein Isoforms, RNA, Messenger, Risk Factors
Added March 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms