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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 18 of 18

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Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.
Lewis LM, Sheffler D, Williams R, Bridges TM, Kennedy JP, Brogan JT, Mulder MJ, Williams L, Nalywajko NT, Niswender CM, Weaver CD, Conn PJ, Lindsley CW
(2008) Bioorg Med Chem Lett 18: 885-90
MeSH Terms: Combinatorial Chemistry Techniques, Dose-Response Relationship, Drug, Dystonia, Heterocyclic Compounds, Humans, Molecular Structure, Muscarinic Antagonists, Parkinson Disease, Receptor, Muscarinic M1, Receptors, G-Protein-Coupled, Receptors, Muscarinic, Structure-Activity Relationship
Added March 5, 2014
1 Communities
4 Members
0 Resources
12 MeSH Terms
The use of temperature-composition combinatorial libraries to study the effects of biodegradable polymer blend surfaces on vascular cells.
Sung HJ, Su J, Berglund JD, Russ BV, Meredith JC, Galis ZS
(2005) Biomaterials 26: 4557-67
MeSH Terms: Animals, Biodegradation, Environmental, Blood Vessels, Cells, Cultured, Combinatorial Chemistry Techniques, Mice, Mice, Inbred C57BL, Polymers, Surface Properties, Temperature
Added May 29, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.
Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ
(2004) J Med Chem 47: 4851-7
MeSH Terms: Binding Sites, Combinatorial Chemistry Techniques, DNA Helicases, DNA, Single-Stranded, DNA-Binding Proteins, Drug Design, Genes, myc, Humans, Inhibitory Concentration 50, Ligands, Magnetic Resonance Spectroscopy, Models, Molecular, Promoter Regions, Genetic, Protein Conformation, Protein Structure, Tertiary, Proto-Oncogene Mas, RNA-Binding Proteins, Repetitive Sequences, Amino Acid, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening.
Hajduk PJ, Betz SF, Mack J, Ruan X, Towne DL, Lerner CG, Beutel BA, Fesik SW
(2002) J Biomol Screen 7: 429-32
MeSH Terms: Bacterial Proteins, Biological Assay, Combinatorial Chemistry Techniques, Haemophilus influenzae, Ligands, Magnetic Resonance Spectroscopy, Spectrometry, Fluorescence
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications.
Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, Joyce S
(2003) J Immunol 170: 5133-42
MeSH Terms: Amino Acid Substitution, Animals, Combinatorial Chemistry Techniques, Conserved Sequence, Epitopes, T-Lymphocyte, H-2 Antigens, Humans, Immunodominant Epitopes, Isoleucine, Membrane Glycoproteins, Membrane Proteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Minor Histocompatibility Antigens, Minor Histocompatibility Loci, Molecular Mimicry, Oligopeptides, Peptide Library, Phosphopeptides, Protein Processing, Post-Translational, Threonine
Added May 19, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Molecular beacon sequence design algorithm.
Monroe WT, Haselton FR
(2003) Biotechniques 34: 68-70, 72-3
MeSH Terms: Algorithms, Base Sequence, Combinatorial Chemistry Techniques, Computer-Aided Design, DNA Probes, Databases, Nucleic Acid, Equipment Design, Fluorescence, Internet, Molecular Probe Techniques, Molecular Sequence Data, Oligonucleotides, Sequence Alignment, Sequence Analysis, DNA, Software
Added May 27, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.
Liu G, Huth JR, Olejniczak ET, Mendoza R, DeVries P, Leitza S, Reilly EB, Okasinski GF, Fesik SW, von Geldern TW
(2001) J Med Chem 44: 1202-10
MeSH Terms: Allosteric Regulation, Amides, Animals, Cinnamates, Combinatorial Chemistry Techniques, Intercellular Adhesion Molecule-1, Ligands, Lymphocyte Function-Associated Antigen-1, Magnetic Resonance Spectroscopy, Models, Molecular, Rats, Solubility, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
NMR-based screening in drug discovery.
Hajduk PJ, Meadows RP, Fesik SW
(1999) Q Rev Biophys 32: 211-40
MeSH Terms: Biophysical Phenomena, Biophysics, Combinatorial Chemistry Techniques, Drug Design, Drug Evaluation, Preclinical, Humans, Ligands, Magnetic Resonance Spectroscopy, Matrix Metalloproteinase Inhibitors, Methyltransferases, Models, Molecular, Papillomaviridae, Tacrolimus Binding Proteins, Viral Proteins, src Homology Domains
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms