Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 11 to 20 of 31

Publication Record

Connections

Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
Mayer IA, Abramson VG, Isakoff SJ, Forero A, Balko JM, Kuba MG, Sanders ME, Yap JT, Van den Abbeele AD, Li Y, Cantley LC, Winer E, Arteaga CL
(2014) J Clin Oncol 32: 1202-9
MeSH Terms: Adult, Aged, Aminopyridines, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Fluorodeoxyglucose F18, Humans, Letrozole, Middle Aged, Morpholines, Multimodal Imaging, Nitriles, Phosphoinositide-3 Kinase Inhibitors, Positron-Emission Tomography, Protein Kinase Inhibitors, Radiopharmaceuticals, Receptor, ErbB-2, Receptors, Estrogen, Tomography, X-Ray Computed, Triazoles
Added March 27, 2014
0 Communities
3 Members
0 Resources
26 MeSH Terms
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer.
Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK
(2014) Cancer Res 74: 3180-94
MeSH Terms: Animals, Breast Neoplasms, Carcinogenesis, Cell Line, Cell Line, Tumor, Cell Polarity, Class I Phosphatidylinositol 3-Kinases, Female, Gene Expression, HEK293 Cells, Humans, Membrane Proteins, Mice, Mice, Transgenic, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins
Added May 20, 2014
1 Communities
2 Members
0 Resources
20 MeSH Terms
Analysis of major known driver mutations and prognosis in resected adenosquamous lung carcinomas.
Wang R, Pan Y, Li C, Zhang H, Garfield D, Li Y, Ye T, Hu H, Luo X, Li H, Zhang Y, Zhang J, Zhou X, Shen L, Pao W, Sun Y, Chen H
(2014) J Thorac Oncol 9: 760-8
MeSH Terms: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Carcinoma, Adenosquamous, Class I Phosphatidylinositol 3-Kinases, Disease-Free Survival, ErbB Receptors, Female, Genotype, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Oncogene Proteins, Fusion, Phosphatidylinositol 3-Kinases, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-ret, Proto-Oncogene Proteins p21(ras), Receptor Protein-Tyrosine Kinases, Receptor, ErbB-2, Survival Rate, ras Proteins
Added March 10, 2014
0 Communities
1 Members
0 Resources
28 MeSH Terms
A patient with metastatic lung adenocarcinoma harboring concurrent EGFR L858R, EGFR germline T790M, and PIK3CA mutations: the challenge of interpreting results of comprehensive mutational testing in lung cancer.
Lammers PE, Lovly CM, Horn L
(2014) J Natl Compr Canc Netw 12: 6-11; quiz 11
MeSH Terms: Adenocarcinoma, Adenocarcinoma of Lung, Aged, Carcinoma, Non-Small-Cell Lung, Class I Phosphatidylinositol 3-Kinases, Crizotinib, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Humans, Lung Neoplasms, Male, Mutation, Phosphatidylinositol 3-Kinases, Precision Medicine, Pyrazoles, Pyridines, Quinazolines, Treatment Outcome
Added June 26, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Direct inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor activity in HER2+ breast cancer cells.
Rexer BN, Chanthaphaychith S, Dahlman K, Arteaga CL
(2014) Breast Cancer Res 16: R9
MeSH Terms: Aminopyridines, Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, Drug Resistance, Neoplasm, Female, Humans, Lapatinib, Mice, Mice, Nude, Morpholines, Mutation, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors, Quinazolines, Receptor, ErbB-2, Trastuzumab, Xenograft Model Antitumor Assays
Added March 10, 2014
0 Communities
3 Members
0 Resources
24 MeSH Terms
Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
Mikhitarian K, Pollen M, Zhao Z, Shyr Y, Merchant NB, Parikh A, Revetta F, Washington MK, Vnencak-Jones C, Shi C
(2014) Mod Pathol 27: 665-74
MeSH Terms: Adenocarcinoma, Aged, Ampulla of Vater, Class I Phosphatidylinositol 3-Kinases, Common Bile Duct Neoplasms, DNA Mutational Analysis, Duodenal Neoplasms, ErbB Receptors, Female, Humans, Male, Middle Aged, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Signal Transduction, ras Proteins
Added March 7, 2014
0 Communities
4 Members
0 Resources
19 MeSH Terms
Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.
Hanker AB, Pfefferle AD, Balko JM, Kuba MG, Young CD, Sánchez V, Sutton CR, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL
(2013) Proc Natl Acad Sci U S A 110: 14372-7
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Class I Phosphatidylinositol 3-Kinases, Drug Resistance, Neoplasm, Epithelial-Mesenchymal Transition, Genes, erbB-2, Lung Neoplasms, Mammary Neoplasms, Experimental, Mice, Mice, Transgenic, Mutation, Phosphatidylinositol 3-Kinases
Added September 3, 2013
1 Communities
4 Members
0 Resources
12 MeSH Terms
Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers.
Garrett JT, Sutton CR, Kurupi R, Bialucha CU, Ettenberg SA, Collins SD, Sheng Q, Wallweber J, Defazio-Eli L, Arteaga CL
(2013) Cancer Res 73: 6013-23
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Breast Neoplasms, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Immunoblotting, Immunoprecipitation, Lapatinib, Mice, Phosphorylation, Protein Multimerization, Proto-Oncogene Proteins c-akt, Quinazolines, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Survival Rate, Trastuzumab, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
2 Members
0 Resources
23 MeSH Terms
PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Deming DA, Leystra AA, Nettekoven L, Sievers C, Miller D, Middlebrooks M, Clipson L, Albrecht D, Bacher J, Washington MK, Weichert J, Halberg RB
(2014) Oncogene 33: 2245-54
MeSH Terms: Adenocarcinoma, Adenomatous Polyposis Coli Protein, Animals, Cell Nucleus, Class I Phosphatidylinositol 3-Kinases, Colorectal Neoplasms, Cyclin D1, Disease Models, Animal, Epistasis, Genetic, Female, Gene Expression, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microsatellite Instability, Phosphatidylinositol 3-Kinases, Tumor Burden, Wnt Signaling Pathway, beta Catenin
Added April 12, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Young CD, Pfefferle AD, Owens P, Kuba MG, Rexer BN, Balko JM, Sánchez V, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL
(2013) Cancer Res 73: 4075-85
MeSH Terms: Animals, Antineoplastic Agents, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Female, Gene Expression, Humans, Hyperplasia, Lapatinib, Mammary Glands, Animal, Mammary Neoplasms, Experimental, Mice, Mice, Nude, Mice, Transgenic, Mutation, Missense, Neoplasm Transplantation, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Binding, Quinazolines, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Transcriptome, Tumor Burden
Added November 12, 2013
2 Communities
6 Members
0 Resources
25 MeSH Terms