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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 19 of 19

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.
Westendorf JJ, Yamamoto CM, Lenny N, Downing JR, Selsted ME, Hiebert SW
(1998) Mol Cell Biol 18: 322-33
MeSH Terms: Animals, CCAAT-Enhancer-Binding Proteins, COS Cells, Cell Differentiation, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Granulocytes, Hematopoiesis, Humans, Leukemia, Nuclear Proteins, Oncogene Proteins, Fusion, Promoter Regions, Genetic, RUNX1 Translocation Partner 1 Protein, Rats, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
22 MeSH Terms
Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.
Rhoades KL, Hetherington CJ, Rowley JD, Hiebert SW, Nucifora G, Tenen DG, Zhang DE
(1996) Proc Natl Acad Sci U S A 93: 11895-900
MeSH Terms: Animals, Bone Marrow, Cell Line, Chlorocebus aethiops, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Core Binding Factor Alpha 2 Subunit, DNA Primers, DNA-Binding Proteins, Humans, Leukemia, Myeloid, Acute, Organ Specificity, Polymerase Chain Reaction, Promoter Regions, Genetic, Proto-Oncogene Proteins, RUNX1 Translocation Partner 1 Protein, Receptor, Macrophage Colony-Stimulating Factor, Transcription Factors, Translocation, Genetic, Tumor Cells, Cultured, Up-Regulation
Added June 10, 2010
1 Communities
1 Members
0 Resources
21 MeSH Terms
AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia.
Meyers S, Lenny N, Sun W, Hiebert SW
(1996) Oncogene 13: 303-12
MeSH Terms: Acute Disease, Amino Acid Sequence, Animals, Antibody Specificity, Base Sequence, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Core Binding Factor Alpha 2 Subunit, DNA, DNA-Binding Proteins, Humans, Leukemia, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Neoplasm Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, RUNX1 Translocation Partner 1 Protein, Rats, Rats, Inbred BUF, Recombinant Fusion Proteins, Repressor Proteins, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Translocation, Genetic, Tumor Cells, Cultured
Added June 10, 2010
1 Communities
1 Members
0 Resources
29 MeSH Terms
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.
Hiebert SW, Sun W, Davis JN, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussell MF, Gilliland DG, Lenny N, Meyers S
(1996) Mol Cell Biol 16: 1349-55
MeSH Terms: Base Sequence, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 21, DNA-Binding Proteins, Enhancer Elements, Genetic, Helix-Loop-Helix Motifs, Humans, Leukemia, Molecular Sequence Data, Proto-Oncogene Proteins c-ets, Recombinant Fusion Proteins, Repressor Proteins, Sequence Deletion, Transcription Factors, Transcription, Genetic, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
16 MeSH Terms
Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO.
Hiebert SW, Downing JR, Lenny N, Meyers S
(1996) Curr Top Microbiol Immunol 211: 253-8
MeSH Terms: Animals, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Cloning, Molecular, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Gene Expression Regulation, Humans, Neoplasm Proteins, Proto-Oncogene Proteins, RUNX1 Translocation Partner 1 Protein, Transcription Factors, Transcription, Genetic, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
14 MeSH Terms
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.
Meyers S, Downing JR, Hiebert SW
(1993) Mol Cell Biol 13: 6336-45
MeSH Terms: Animals, Base Sequence, Cell Line, Chromosomes, Human, Pair 21, Core Binding Factor Alpha 2 Subunit, DNA, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Enhancer Elements, Genetic, Humans, Leukemia, Myeloid, Acute, Molecular Sequence Data, Neoplasm Proteins, Nuclear Proteins, Proto-Oncogene Proteins, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Translocation, Genetic, Tumor Cells, Cultured
Added June 10, 2010
1 Communities
1 Members
0 Resources
21 MeSH Terms
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG
(1995) Proc Natl Acad Sci U S A 92: 4917-21
MeSH Terms: Amino Acid Sequence, Base Sequence, Blotting, Southern, Bone Marrow, Child, Preschool, Chromosome Mapping, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 21, Cloning, Molecular, Core Binding Factor Alpha 2 Subunit, DNA Primers, DNA-Binding Proteins, Gene Rearrangement, Helix-Loop-Helix Motifs, Humans, Karyotyping, Molecular Sequence Data, Neoplasm Proteins, Oncogene Proteins, Fusion, Polymerase Chain Reaction, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, Repressor Proteins, Transcription Factors
Added June 10, 2010
1 Communities
1 Members
0 Resources
25 MeSH Terms
Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM.
Tsaur ML, Menzel S, Lai FP, Espinosa R, Concannon P, Spielman RS, Hanis CL, Cox NJ, Le Beau MM, German MS
(1995) Diabetes 44: 592-6
MeSH Terms: Adenosine Triphosphate, Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Artificial, Yeast, Chromosomes, Human, Pair 21, Cricetinae, DNA Primers, DNA, Complementary, Diabetes Mellitus, Type 2, Genetic Linkage, Humans, In Situ Hybridization, Fluorescence, Insulin, Insulin Secretion, Islets of Langerhans, Molecular Sequence Data, Potassium Channels, RNA, Messenger, Tissue Distribution, Tumor Cells, Cultured
Added February 22, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms
Functional domains of the t(8;21) fusion protein, AML-1/ETO.
Lenny N, Meyers S, Hiebert SW
(1995) Oncogene 11: 1761-9
MeSH Terms: Adenosine Triphosphate, Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Cell Line, Chlorocebus aethiops, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Glutathione Transferase, Humans, Kidney, Leukemia, Myeloid, Acute, Molecular Sequence Data, Mutagenesis, Mutagenesis, Site-Directed, Neoplasm Proteins, Proto-Oncogene Proteins, RUNX1 Translocation Partner 1 Protein, Recombinant Fusion Proteins, Sequence Deletion, Transcription Factors, Transfection, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
26 MeSH Terms