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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 22

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Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance.
Holmstrand EC, Lund D, Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD
(2014) Neurochem Int 73: 217-28
MeSH Terms: Acetylcholine, Animals, Behavior, Animal, Choline, Cholinergic Agents, Chromosomes, Artificial, Bacterial, Gene Dosage, Hemicholinium 3, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Physical Endurance, Receptors, Presynaptic, Synaptosomes
Added December 2, 2013
1 Communities
2 Members
0 Resources
15 MeSH Terms
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Le U, Melancon BJ, Bridges TM, Vinson PN, Utley TJ, Lamsal A, Rodriguez AL, Venable D, Sheffler DJ, Jones CK, Blobaum AL, Wood MR, Daniels JS, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR
(2013) Bioorg Med Chem Lett 23: 346-50
MeSH Terms: Allosteric Regulation, Amides, Animals, Brain, Cholinergic Agents, Disease Models, Animal, Drug Evaluation, Preclinical, Half-Life, Humans, Protein Binding, Pyridines, Rats, Receptor, Muscarinic M4, Schizophrenia, Structure-Activity Relationship, Thiophenes
Added September 12, 2013
1 Communities
5 Members
0 Resources
16 MeSH Terms
Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice.
Zurkovsky L, Bychkov E, Tsakem EL, Siedlecki C, Blakely RD, Gurevich EV
(2013) Dis Model Mech 6: 171-83
MeSH Terms: Acetylcholine, Animals, Cholinergic Agents, Cognition Disorders, Dementia, Disease Models, Animal, Dopamine, Hemicholinium 3, Humans, Male, Membrane Transport Proteins, Memory, Mice, Mice, Inbred C57BL, Mice, Knockout, Parkinsonian Disorders, Signal Transduction
Added July 10, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM.
Bridges TM, Phillip Kennedy J, Noetzel MJ, Breininger ML, Gentry PR, Conn PJ, Lindsley CW
(2010) Bioorg Med Chem Lett 20: 1972-5
MeSH Terms: Allosteric Regulation, Cholinergic Agents, Drug Design, Receptors, Muscarinic, Structure-Activity Relationship
Added February 19, 2015
0 Communities
1 Members
0 Resources
5 MeSH Terms
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ
(2009) J Neurosci 29: 14271-86
MeSH Terms: Animals, CHO Cells, Carboxylic Acids, Cholinergic Agents, Cricetinae, Cricetulus, Female, Humans, In Vitro Techniques, Learning Disabilities, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Neurons, Prefrontal Cortex, Quinolones, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1, Reversal Learning
Added February 19, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Why amiodarone is better: another piece of the puzzle.
Murray KT
(2009) J Cardiovasc Electrophysiol 20: 811-2
MeSH Terms: Acetylcholine, Action Potentials, Adrenergic beta-Agonists, Amiodarone, Animals, Anti-Arrhythmia Agents, Atrial Fibrillation, Calcium, Cholinergic Agents, Heart Conduction System, Heart Ventricles, Humans, Isoproterenol, Pulmonary Veins, Time Factors
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice.
Bazalakova MH, Wright J, Schneble EJ, McDonald MP, Heilman CJ, Levey AI, Blakely RD
(2007) Genes Brain Behav 6: 411-24
MeSH Terms: Acetylcholine, Animals, Anxiety, Brain, Cholinergic Agents, Exploratory Behavior, Hemicholinium 3, Heterozygote, Maze Learning, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Receptors, Muscarinic, Rotarod Performance Test, Scopolamine, Spatial Behavior
Added July 10, 2013
1 Communities
2 Members
0 Resources
18 MeSH Terms
The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner.
Matthies DS, Fleming PA, Wilkes DM, Blakely RD
(2006) J Neurosci 26: 6200-12
MeSH Terms: Acetylcholine, Adaptation, Physiological, Animals, Animals, Genetically Modified, Binding, Competitive, Biological Transport, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cells, Cultured, Choline, Cholinergic Agents, Electrophysiology, Gene Deletion, Green Fluorescent Proteins, Hemicholinium 3, Membrane Transport Proteins, Motor Activity, Nerve Tissue Proteins, Recombinant Fusion Proteins, Signal Transduction, Synapses, Tissue Distribution
Added July 10, 2013
1 Communities
1 Members
0 Resources
22 MeSH Terms
Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice.
Ferguson SM, Bazalakova M, Savchenko V, Tapia JC, Wright J, Blakely RD
(2004) Proc Natl Acad Sci U S A 101: 8762-7
MeSH Terms: Acetylcholine, Animals, Brain, Choline O-Acetyltransferase, Cholinergic Agents, Hemicholinium 3, In Vitro Techniques, Membrane Transport Proteins, Mice, Mice, Knockout, Motor Neurons, Neuromuscular Junction, Phenotype, Synaptic Transmission, Synaptosomes
Added July 10, 2013
2 Communities
1 Members
0 Resources
15 MeSH Terms
The choline transporter resurfaces: new roles for synaptic vesicles?
Ferguson SM, Blakely RD
(2004) Mol Interv 4: 22-37
MeSH Terms: Acetylcholine, Animals, Cell Membrane, Choline, Cholinergic Agents, Hemicholinium 3, Humans, Membrane Transport Proteins, Neurons, Presynaptic Terminals, Synaptic Transmission, Synaptic Vesicles
Added July 10, 2013
1 Communities
1 Members
0 Resources
12 MeSH Terms