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Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination.
Grier MD, West KL, Kelm ND, Fu C, Does MD, Parker B, McBrier E, Lagrange AH, Ess KC, Carson RP
(2017) PLoS One 12: e0188417
MeSH Terms: Animals, Cell Differentiation, Cell Proliferation, Central Nervous System, Gene Expression Regulation, Developmental, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Knockout, Myelin Sheath, Oligodendrocyte Precursor Cells, Rapamycin-Insensitive Companion of mTOR Protein, Signal Transduction, White Matter
Added March 14, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo.
Melchior JR, Jones SR
(2017) Mol Cell Neurosci 85: 93-104
MeSH Terms: Alcoholism, Animals, Central Nervous System Depressants, Dopamine, Dopaminergic Neurons, Ethanol, Gene Knock-In Techniques, Male, Mice, Mice, Inbred C57BL, Nucleus Accumbens, Optogenetics, Organ Culture Techniques, Receptors, Opioid, kappa, Synaptic Transmission
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery of a novel, CNS penetrant M PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.
Bewley BR, Spearing PK, Weiner RL, Luscombe VB, Zhan X, Chang S, Cho HP, Rodriguez AL, Niswender CM, Conn PJ, Bridges TM, Engers DW, Lindsley CW
(2017) Bioorg Med Chem Lett 27: 4274-4279
MeSH Terms: Animals, Central Nervous System, Dose-Response Relationship, Drug, Drug Discovery, Humans, Molecular Structure, Piperidines, Quinolines, Rats, Receptor, Muscarinic M4, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
OCD candidate gene /EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
Zike ID, Chohan MO, Kopelman JM, Krasnow EN, Flicker D, Nautiyal KM, Bubser M, Kellendonk C, Jones CK, Stanwood G, Tanaka KF, Moore H, Ahmari SE, Veenstra-VanderWeele J
(2017) Proc Natl Acad Sci U S A 114: 5719-5724
MeSH Terms: Amphetamines, Animals, Basal Ganglia, Cell Line, Central Nervous System Stimulants, Dopamine, Excitatory Amino Acid Transporter 3, Glutamic Acid, Grooming, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Obsessive-Compulsive Disorder, Receptors, Dopamine D1, Reflex, Startle
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Arrestin-2 and arrestin-3 differentially modulate locomotor responses and sensitization to amphetamine.
Zurkovsky L, Sedaghat K, Ahmed MR, Gurevich VV, Gurevich EV
(2017) Neuropharmacology 121: 20-29
MeSH Terms: Amphetamine, Analysis of Variance, Animals, Arrestins, Central Nervous System Stimulants, Locomotion, Mice, Mice, Inbred C57BL, Mice, Knockout, Time Factors, beta-Arrestin 1
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease.
Pfalzer AC, Bowman AB
(2017) Curr Environ Health Rep 4: 223-228
MeSH Terms: Aging, Central Nervous System Diseases, Humans, Manganese, Manganese Poisoning, Neurotoxicity Syndromes, Risk Factors
Added April 26, 2017
0 Communities
1 Members
0 Resources
7 MeSH Terms
Classics in Chemical Neuroscience: Xanomeline.
Bender AM, Jones CK, Lindsley CW
(2017) ACS Chem Neurosci 8: 435-443
MeSH Terms: Animals, Central Nervous System Diseases, Humans, Muscarinic Agonists, Neurosciences, Pyridines, Thiadiazoles
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core.
Nance KD, Days EL, Weaver CD, Coldren A, Farmer TD, Cho HP, Niswender CM, Blobaum AL, Niswender KD, Lindsley CW
(2017) J Med Chem 60: 1611-1616
MeSH Terms: Administration, Oral, Animals, Blood Glucose, Cells, Cultured, Central Nervous System, Glucagon-Like Peptide-1 Receptor, Halogenation, Humans, Insulin, Islets of Langerhans, Male, Pyrimidines, Rats, Sprague-Dawley
Added April 6, 2017
0 Communities
3 Members
0 Resources
13 MeSH Terms
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
Wood MR, Noetzel MJ, Tarr JC, Rodriguez AL, Lamsal A, Chang S, Foster JJ, Smith E, Chase P, Hodder PS, Engers DW, Niswender CM, Brandon NJ, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 4282-6
MeSH Terms: Allosteric Regulation, Animals, Central Nervous System, Drug Discovery, Humans, Ketones, Molecular Structure, Receptor, Muscarinic M1, Structure-Activity Relationship
Added April 6, 2017
0 Communities
2 Members
0 Resources
9 MeSH Terms
Temporal summation to thermal stimuli is elevated in women with overactive bladder syndrome.
Reynolds WS, Brown ET, Danford J, Kaufman M, Wein A, Dmochowski R, Bruehl S
(2017) Neurourol Urodyn 36: 1108-1112
MeSH Terms: Adult, Afferent Pathways, Aged, Central Nervous System Sensitization, Female, Hot Temperature, Humans, Hyperesthesia, Middle Aged, Pain, Pain Measurement, Pain Perception, Pain Threshold, Urinary Bladder, Overactive
Added September 16, 2019
0 Communities
1 Members
0 Resources
MeSH Terms