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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 310

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Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.
Bhuripanyo K, Wang Y, Liu X, Zhou L, Liu R, Duong D, Zhao B, Bi Y, Zhou H, Chen G, Seyfried NT, Chazin WJ, Kiyokawa H, Yin J
(2018) Sci Adv 4: e1701393
MeSH Terms: Amino Acid Sequence, Bacteriophages, Biocatalysis, Cyclin-Dependent Kinase 4, Endoplasmic Reticulum Stress, HEK293 Cells, Humans, Mutant Proteins, Mutation, Peptides, Proteolysis, Reproducibility of Results, Signal Transduction, Substrate Specificity, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Ubiquitin, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Ubiquitination
Added March 24, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions.
Guengerich FP
(2017) Methods Enzymol 596: 217-238
MeSH Terms: Biocatalysis, Cytochrome P-450 Enzyme System, Deuterium, Enzyme Assays, Humans, Hydrogen Bonding, Kinetics, Models, Chemical, Oxidation-Reduction, Substrate Specificity
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
(2017) J Biol Chem 292: 13672-13687
MeSH Terms: Biocatalysis, Cytochrome P450 Family 27, Diterpenes, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Humans, Hydrogenation, Hydroxylation, Isoenzymes, Kinetics, Mitochondria, Molecular Structure, Organ Specificity, Oxidation-Reduction, Peptide Fragments, Proteolysis, Proteomics, Skin, Stereoisomerism, Substrate Specificity, Vitamin A
Added March 14, 2018
0 Communities
1 Members
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21 MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.
Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M
(2018) Xenobiotica 48: 565-575
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Biocatalysis, Cytochrome P-450 CYP1B1, Humans, Molecular Docking Simulation, Oxidation-Reduction, Pyrenes
Added March 14, 2018
0 Communities
1 Members
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8 MeSH Terms
cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.
Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA
(2017) J Biol Chem 292: 12934-12946
MeSH Terms: Acetylcholine, Alkynes, Allosteric Regulation, Amino Acid Substitution, Anti-HIV Agents, Aspartic Acid, Benzoxazines, Binding Sites, Biocatalysis, Cholesterol 24-Hydroxylase, Cyclopropanes, Deuterium Exchange Measurement, Enzyme Activation, Glutamic Acid, Ligands, Models, Molecular, Molecular Docking Simulation, Mutagenesis, Site-Directed, Mutation, Nerve Tissue Proteins, Peptide Fragments, Protein Conformation, Recombinant Fusion Proteins, gamma-Aminobutyric Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
24 MeSH Terms
Pyridine Dinucleotides from Molecules to Man.
Fessel JP, Oldham WM
(2018) Antioxid Redox Signal 28: 180-212
MeSH Terms: ADP-ribosyl Cyclase 1, Adenosine Triphosphate, Biosynthetic Pathways, Catalysis, Disease Susceptibility, Energy Metabolism, Homeostasis, Humans, Hydrolysis, Intracellular Space, Male, Mitochondria, NAD, NADP, NADPH Oxidases, Nitric Oxide Synthase, Oxidation-Reduction, Pyridines, Reactive Oxygen Species, Stress, Physiological
Added March 14, 2018
0 Communities
1 Members
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20 MeSH Terms
Structural and biochemical analyses reveal insights into covalent flavinylation of the Complex II homolog quinol:fumarate reductase.
Starbird CA, Maklashina E, Sharma P, Qualls-Histed S, Cecchini G, Iverson TM
(2017) J Biol Chem 292: 12921-12933
MeSH Terms: Amino Acid Substitution, Biocatalysis, Crystallography, X-Ray, Enzyme Stability, Escherichia coli, Escherichia coli Proteins, Flavin-Adenine Dinucleotide, Gene Deletion, Glutamic Acid, Hot Temperature, Models, Molecular, Molecular Docking Simulation, Mutagenesis, Site-Directed, Mutation, Oxidoreductases, Protein Conformation, Protein Denaturation, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Processing, Post-Translational, Protein Subunits, Recombinant Proteins, Structural Homology, Protein, Succinate Dehydrogenase
Added April 1, 2019
0 Communities
1 Members
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MeSH Terms
Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP
(2017) J Biol Chem 292: 11230-11242
MeSH Terms: Animals, Catalysis, Cytochrome P-450 CYP4A, Dithiothreitol, Heme, Humans, Hydrogen Peroxide, Hydroxyeicosatetraenoic Acids, Kidney, Liver, Mice, Mice, Transgenic, Oxidation-Reduction, Rats
Added March 14, 2018
0 Communities
1 Members
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14 MeSH Terms
Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl.
Shimada T, Kakimoto K, Takenaka S, Koga N, Uehara S, Murayama N, Yamazaki H, Kim D, Guengerich FP, Komori M
(2016) Drug Metab Dispos 44: 1899-1909
MeSH Terms: Animals, Catalysis, Catalytic Domain, Cytochrome P-450 CYP2A6, Cytochrome P-450 Enzyme System, Haplorhini, Humans, Ligands, Molecular Docking Simulation, Oxidation-Reduction, Polychlorinated Biphenyls, Protein Binding
Added March 14, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms