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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 59

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cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.
Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA
(2017) J Biol Chem 292: 12934-12946
MeSH Terms: Acetylcholine, Alkynes, Allosteric Regulation, Amino Acid Substitution, Anti-HIV Agents, Aspartic Acid, Benzoxazines, Binding Sites, Biocatalysis, Cholesterol 24-Hydroxylase, Cyclopropanes, Deuterium Exchange Measurement, Enzyme Activation, Glutamic Acid, Ligands, Models, Molecular, Molecular Docking Simulation, Mutagenesis, Site-Directed, Mutation, Nerve Tissue Proteins, Peptide Fragments, Protein Conformation, Recombinant Fusion Proteins, gamma-Aminobutyric Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
24 MeSH Terms
Structural and biochemical analyses reveal insights into covalent flavinylation of the Complex II homolog quinol:fumarate reductase.
Starbird CA, Maklashina E, Sharma P, Qualls-Histed S, Cecchini G, Iverson TM
(2017) J Biol Chem 292: 12921-12933
MeSH Terms: Amino Acid Substitution, Biocatalysis, Crystallography, X-Ray, Enzyme Stability, Escherichia coli, Escherichia coli Proteins, Flavin-Adenine Dinucleotide, Gene Deletion, Glutamic Acid, Hot Temperature, Models, Molecular, Molecular Docking Simulation, Mutagenesis, Site-Directed, Mutation, Oxidoreductases, Protein Conformation, Protein Denaturation, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Processing, Post-Translational, Protein Subunits, Recombinant Proteins, Structural Homology, Protein, Succinate Dehydrogenase
Added April 1, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
A Catalytic Role for C-H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD.
Parsons ZD, Bland JM, Mullins EA, Eichman BF
(2016) J Am Chem Soc 138: 11485-8
MeSH Terms: Bacillus cereus, Biocatalysis, DNA Glycosylases, DNA Repair, DNA, Bacterial
Added April 7, 2017
1 Communities
1 Members
0 Resources
5 MeSH Terms
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.
Malabanan MM, Blind RD
(2016) Biochem Soc Trans 44: 279-85
MeSH Terms: Animals, Biocatalysis, Cell Nucleus, Gene Expression Regulation, Humans, Inositol, Phosphotransferases (Alcohol Group Acceptor), Transcription, Genetic
Added January 19, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF
(2015) Nature 527: 254-8
MeSH Terms: Bacillus cereus, Base Pairing, Biocatalysis, Catalytic Domain, Crystallography, X-Ray, DNA Adducts, DNA Damage, DNA Glycosylases, DNA Repair, Duocarmycins, Indoles, Models, Molecular, Pyrroles
Added November 10, 2015
1 Communities
1 Members
0 Resources
13 MeSH Terms
5'-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1,2-Dicarbonyls.
Amarnath V, Amarnath K, Avance J, Stec DF, Voziyan P
(2015) Chem Res Toxicol 28: 1469-75
MeSH Terms: Biocatalysis, Electron Spin Resonance Spectroscopy, Free Radical Scavengers, Free Radicals, Glucose, Horseradish Peroxidase, Hydrophobic and Hydrophilic Interactions, Membrane Proteins, Molecular Conformation, Muramidase, Pyridoxamine, Pyruvaldehyde, Spectrophotometry, Ultraviolet, Superoxide Dismutase
Added June 9, 2017
1 Communities
2 Members
0 Resources
14 MeSH Terms
Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.
Teder T, Boeglin WE, Brash AR
(2014) J Lipid Res 55: 2587-96
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Animals, Arachidonate 12-Lipoxygenase, Arachidonate 15-Lipoxygenase, Biocatalysis, Blood Platelets, Chromatography, High Pressure Liquid, Eicosanoids, Epoxy Compounds, Gas Chromatography-Mass Spectrometry, Humans, Hydroxylation, Linolenic Acids, Lipid Peroxides, Lipoxygenase, Mice, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Recombinant Proteins, Soybean Proteins, Spectrometry, Mass, Electrospray Ionization, Stereoisomerism
Added January 21, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition.
Cherkesova TS, Hargrove TY, Vanrell MC, Ges I, Usanov SA, Romano PS, Lepesheva GI
(2014) FEBS Lett 588: 3878-85
MeSH Terms: 14-alpha Demethylase Inhibitors, Amino Acid Sequence, Amino Acid Substitution, Animals, Biocatalysis, Chagas Disease, Conserved Sequence, Cytochrome P-450 Enzyme System, Humans, Models, Molecular, Molecular Sequence Data, Protein Conformation, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11.
Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP
(2014) Biochemistry 53: 6161-72
MeSH Terms: Algorithms, Binding, Competitive, Biocatalysis, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Cytochromes b5, Deuterium, Electron Transport, Ferric Compounds, Ferrous Compounds, Humans, Hydroxylation, Kinetics, Lauric Acids, Models, Chemical, Models, Molecular, Oxidation-Reduction, Protein Binding, Protein Structure, Tertiary, Substrate Specificity, Tritium
Added January 20, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.
Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG
(2014) J Biol Chem 289: 29614-30
MeSH Terms: Alternative Splicing, Amino Acid Sequence, Amino Acids, Animals, Arachidonic Acid, Aryl Hydrocarbon Hydroxylases, Biocatalysis, COS Cells, Cell Respiration, Chlorocebus aethiops, Computer Simulation, Cytochrome P-450 CYP2C8, Heme, Hep G2 Cells, Humans, Isoenzymes, Microsomes, Liver, Mitochondria, Models, Molecular, Molecular Sequence Data, Oxidation-Reduction, Oxidative Stress, Protein Binding, Protein Transport, RNA, Messenger, Reactive Oxygen Species, Sequence Alignment
Added January 20, 2015
0 Communities
2 Members
0 Resources
27 MeSH Terms