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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 25

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Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
Hayes MG, Urbanek M, Hivert MF, Armstrong LL, Morrison J, Guo C, Lowe LP, Scheftner DA, Pluzhnikov A, Levine DM, McHugh CP, Ackerman CM, Bouchard L, Brisson D, Layden BT, Mirel D, Doheny KF, Leya MV, Lown-Hecht RN, Dyer AR, Metzger BE, Reddy TE, Cox NJ, Lowe WL, HAPO Study Cooperative Research Group
(2013) Diabetes 62: 3282-91
MeSH Terms: Adolescent, Adult, Amyloid Precursor Protein Secretases, Aspartic Acid Endopeptidases, Blood Glucose, C-Peptide, Fasting, Female, Genome-Wide Association Study, Genotype, Glucose Tolerance Test, Humans, Pregnancy, Young Adult
Added February 22, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.
Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D
(2013) J Am Chem Soc 135: 1317-29
MeSH Terms: Amyloid Precursor Protein Secretases, Amyloid beta-Peptides, Models, Molecular, Thermodynamics
Added May 28, 2014
1 Communities
1 Members
0 Resources
4 MeSH Terms
Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.
Shi J, Wang Q, Johansson JU, Liang X, Woodling NS, Priyam P, Loui TM, Merchant M, Breyer RM, Montine TJ, Andreasson K
(2012) Ann Neurol 72: 788-98
MeSH Terms: Age Factors, Alzheimer Disease, Amyloid Precursor Protein Secretases, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Analysis of Variance, Animals, Animals, Newborn, Aspartic Acid Endopeptidases, Brain, Calcium-Binding Proteins, Cells, Cultured, Cognitive Dysfunction, DNA-Binding Proteins, Dinoprostone, Disease Models, Animal, Encephalitis, Female, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microfilament Proteins, Microtubule-Associated Proteins, Mutation, Neurons, Oxidative Stress, Peptide Fragments, Prostaglandin-Endoperoxide Synthases, RNA, Messenger, Receptors, Prostaglandin E, EP3 Subtype, Signal Transduction, Synaptosomal-Associated Protein 25, Vesicle-Associated Membrane Protein 2
Added December 21, 2013
2 Communities
1 Members
0 Resources
37 MeSH Terms
Regulated intramembrane cleavage of the EGF receptor.
Liao HJ, Carpenter G
(2012) Traffic 13: 1106-12
MeSH Terms: Amyloid Precursor Protein Secretases, Calpain, Cell Line, Tumor, Cell Membrane, Cell Nucleus, Epidermal Growth Factor, ErbB Receptors, Gene Expression, Glycoproteins, HEK293 Cells, Humans, Ionomycin, Proteolysis, Quinazolines, Serine Endopeptidases, Serine Proteinase Inhibitors, Tyrphostins
Added August 23, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
Vo K, Amarasinghe B, Washington K, Gonzalez A, Berlin J, Dang TP
(2011) Mol Cancer 10: 138
MeSH Terms: Amyloid Precursor Protein Secretases, Animals, Antibiotics, Antineoplastic, Cell Line, Tumor, Female, Humans, Mice, Mice, Nude, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphorylation, Receptors, Notch, Signal Transduction, Sirolimus
Added April 12, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
Barrett PJ, Sanders CR, Kaufman SA, Michelsen K, Jordan JB
(2011) Biochemistry 50: 10328-42
MeSH Terms: Alzheimer Disease, Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Anti-Inflammatory Agents, Non-Steroidal, Enzyme Inhibitors, Humans, Kinetics, Peptides, Protein Binding, Protein Processing, Post-Translational
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.
Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K
(2010) J Clin Invest 120: 4040-54
MeSH Terms: Amyloid Precursor Protein Secretases, Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium-Binding Proteins, Cell Proliferation, Epithelial Cells, Fibrosis, Homeodomain Proteins, Humans, Intercellular Signaling Peptides and Proteins, Kidney, Kidney Failure, Chronic, Kidney Tubules, Male, Membrane Proteins, Mice, Mice, Transgenic, Nephritis, Interstitial, Receptor, Notch1, Serrate-Jagged Proteins, Signal Transduction, Transcription Factor HES-1
Added August 19, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein.
Beel AJ, Barrett P, Schnier PD, Hitchcock SA, Bagal D, Sanders CR, Jordan JB
(2009) Biochemistry 48: 11837-9
MeSH Terms: Alzheimer Disease, Amino Acid Sequence, Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Humans, Micelles, Molecular Sequence Data, Peptide Fragments, Protein Binding, Substrate Specificity
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Notch promotes radioresistance of glioma stem cells.
Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, Rich JN, Sullenger BA
(2010) Stem Cells 28: 17-28
MeSH Terms: AC133 Antigen, Amyloid Precursor Protein Secretases, Animals, Antigens, CD, Cell Death, Cell Proliferation, Cell Survival, Dose-Response Relationship, Radiation, Enzyme Inhibitors, Glioblastoma, Glycoproteins, Humans, Mice, Mice, Nude, Myeloid Cell Leukemia Sequence 1 Protein, Neoplastic Stem Cells, Peptides, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, RNA Interference, Radiation Tolerance, Radiation-Sensitizing Agents, Receptor, Notch1, Receptor, Notch2, Signal Transduction, Spheroids, Cellular, Time Factors, Transfection, Tumor Burden, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
32 MeSH Terms
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?
Beel AJ, Mobley CK, Kim HJ, Tian F, Hadziselimovic A, Jap B, Prestegard JH, Sanders CR
(2008) Biochemistry 47: 9428-46
MeSH Terms: Amino Acid Motifs, Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Cholesterol, Dimerization, Humans, Membranes, Artificial, Models, Chemical, Peptides, Protein Processing, Post-Translational, Protein Structure, Tertiary, Protein Transport
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms