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Results: 11 to 20 of 41

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Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Guengerich FP
(2005) Arch Biochem Biophys 433: 369-78
MeSH Terms: Aflatoxin B1, Animals, Biotransformation, Butadienes, Cross-Linking Reagents, DNA, DNA Adducts, DNA Damage, DNA Repair, Dose-Response Relationship, Drug, Enzyme Activation, Escherichia coli, Ethylene Dibromide, Forecasting, Genes, Bacterial, Glutathione, Half-Life, Humans, Hydrolysis, Kinetics, Lysine, Models, Chemical, Molecular Structure, Mutagenicity Tests, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Oxidation-Reduction, Salmonella typhimurium, Signal Transduction, Tetrachloroethylene, Trichloroethylene
Added March 5, 2014
0 Communities
1 Members
0 Resources
32 MeSH Terms
Wobble dC.dA pairing 5' to the cationic guanine N7 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 adduct: implications for nontargeted AFB1 mutagenesis.
Giri I, Stone MP
(2003) Biochemistry 42: 7023-34
MeSH Terms: Aflatoxin B1, Base Composition, Base Pair Mismatch, Base Sequence, Cations, DNA Adducts, Deoxyadenine Nucleotides, Deoxycytosine Nucleotides, Guanine, Hydrogen-Ion Concentration, Intercalating Agents, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Nucleic Acid Conformation, Nucleic Acid Heteroduplexes, Oligodeoxyribonucleotides, Protons, Structure-Activity Relationship
Added May 29, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Effects of intermittent exposure to aflatoxin B1 on DNA and RNA adduct formation in rat liver: dose-response and temporal patterns.
Sotomayor RE, Washington M, Nguyen L, Nyang'anyi R, Hinton DM, Chou M
(2003) Toxicol Sci 73: 329-38
MeSH Terms: Aflatoxin B1, Animals, Body Weight, Chromatography, High Pressure Liquid, DNA Adducts, Diet, Dose-Response Relationship, Drug, Drug Administration Schedule, Eating, Liver, Male, Mutagens, Organ Size, RNA, Rats, Rats, Inbred F344, Time Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions.
Guengerich FP
(2003) Arch Biochem Biophys 409: 59-71
MeSH Terms: Aflatoxin B1, Alkenes, Cytochrome P-450 Enzyme System, Epoxy Compounds, Hydrocarbons, Kinetics, Lysine, Magnetic Resonance Spectroscopy, Models, Chemical, Oxygen, Urethane
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Thermal stabilization of the DNA duplex by adducts of aflatoxin B1.
Giri I, Stone MP
(2002) Biopolymers 65: 190-201
MeSH Terms: Aflatoxin B1, Base Sequence, Cations, DNA, DNA Adducts, Magnetic Resonance Spectroscopy, Models, Molecular, Nucleic Acid Conformation, Thermodynamics
Added May 29, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine.
Guengerich FP, Voehler M, Williams KM, Deng Z, Harris TM
(2002) Chem Res Toxicol 15: 793-8
MeSH Terms: Aflatoxin B1, Aldehydes, Buffers, Chromatography, High Pressure Liquid, Cyclization, Hydrogen-Ion Concentration, Mass Spectrometry, Methylamines, Nuclear Magnetic Resonance, Biomolecular, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Reaction of aflatoxin B(1) oxidation products with lysine.
Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM
(2002) Chem Res Toxicol 15: 780-92
MeSH Terms: Aflatoxin B1, Aldehydes, Animals, Binding Sites, Binding, Competitive, Buffers, Cattle, Chromatography, High Pressure Liquid, Glutathione, Hydrogen-Ion Concentration, Kinetics, Lysine, Oxidation-Reduction, Serum Albumin, Serum Albumin, Bovine, Spectrometry, Mass, Electrospray Ionization, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Spectrophotometry, Ultraviolet
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Structural refinement of the 8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B(1) adduct in a 5'-Cp(AFB)G-3' sequence.
Giri I, Jenkins MD, Schnetz-Boutaud NC, Stone MP
(2002) Chem Res Toxicol 15: 638-47
MeSH Terms: Aflatoxin B1, Models, Molecular, Molecular Conformation, Oligodeoxyribonucleotides, Stereoisomerism, Structure-Activity Relationship
Added May 29, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Mispairing of the 8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B1 adduct with deoxyadenosine results in extrusion of the mismatched dA toward the major groove.
Giri I, Johnston DS, Stone MP
(2002) Biochemistry 41: 5462-72
MeSH Terms: Aflatoxin B1, Base Composition, Base Pair Mismatch, DNA Adducts, Deoxyadenosines, Drug Stability, Hot Temperature, Intercalating Agents, Nuclear Magnetic Resonance, Biomolecular, Nucleic Acid Conformation, Nucleic Acid Heteroduplexes, Oligodeoxyribonucleotides, Protons
Added May 29, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Reactive intermediates in biological systems: what have we learned and where are we going?
Guengerich FP, Cai H, Johnson WW, Parikh A
(2001) Adv Exp Med Biol 500: 639-50
MeSH Terms: Aflatoxin B1, Amines, Carcinogens, Trichloroethylene
Added March 5, 2014
0 Communities
1 Members
0 Resources
4 MeSH Terms