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Comparison of median sternotomy and thoracotomy for resection of pulmonary metastases in patients with adult soft-tissue sarcomas.
Roth JA, Pass HI, Wesley MN, White D, Putnam JB, Seipp C
(1986) Ann Thorac Surg 42: 134-8
MeSH Terms: Adult, Female, Follow-Up Studies, Humans, Lung Neoplasms, Male, Retrospective Studies, Sarcoma, Sternum, Thoracic Surgery
Show Abstract · Added March 27, 2014
Thoracotomy and median sternotomy have both been advocated for resection of pulmonary metastases, and the advantages of each approach remain disputed. Patients with adult soft-tissue sarcomas undergoing resection of pulmonary metastases at the National Cancer Institute were studied retrospectively to assess the results of each surgical approach. Between 1981 and 1984, 65 patients underwent 78 sternotomies (7 lobectomies, 71 wedge resections); a mean of 9.5 nodules were resected per patient (range, 1 to 61). Resection of all nodules was accomplished in 60 of 71 explorations (84%) in patients with documented metastases. Benign lesions were found during 7 explorations (9%). Thirteen of 30 patients (43%) with unilateral metastases on linear tomography (LT), 45% (9 of 20) of patients with unilateral metastases on computed tomography (CT), and 38% (5 of 13) of patients with unilateral metastases on both CT and LT had bilateral metastases at sternotomy. Survival by type of incision was compared for 84 patients who underwent complete resection of their metastases (42 by sternotomy and 42 by thoracotomy); the minimum follow-up was two years. The groups did not differ significantly with respect to prognostic variables (tumor doubling time, disease-free interval, or number of nodules resected). There was no significant difference in actuarial survival between the two groups. The complication rate was 15% for the sternotomy group and 10% for the thoracotomy group (difference not significant). There were no operative deaths. Median sternotomy results in detection of unsuspected bilateral metastases and avoidance of a second operative procedure, but it does not increase operative morbidity or mortality or compromise overall patient survival.
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10 MeSH Terms
Serial micropuncture analysis of glomerular function in two rat models of glomerular sclerosis.
Fogo A, Yoshida Y, Glick AD, Homma T, Ichikawa I
(1988) J Clin Invest 82: 322-30
MeSH Terms: Animals, Blood Pressure, Blood Urea Nitrogen, Body Weight, Chronic Disease, Disease Models, Animal, Doxorubicin, Glomerular Filtration Rate, Glomerulonephritis, Glomerulosclerosis, Focal Segmental, Kidney Glomerulus, Microsurgery, Proteinuria, Punctures, Puromycin Aminonucleoside, Rats, Rats, Inbred Strains
Show Abstract · Added January 20, 2012
We have recently developed a micropuncture technique to assess repeatedly function of the same nephrons in chronic renal disease and subsequently examine the morphology of their glomeruli by serial thin-section histological analysis. Using this approach, a potential causal linkage between early functional patterns and late structural abnormalities was examined in glomeruli of two established rat models of glomerular sclerosis. The models are (a) puromycin aminonucleoside (PAN) administration in unilaterally nephrectomized Munich-Wistar rats and (b) adriamycin (ADM) treatment in nonnephrectomized Munich-Wistar rats. Single nephron GFR (SNGFR) and glomerular capillary hydraulic pressure (PGC) were measured repeatedly for 8 (PAN rats) or 31 wk (ADM rats). In all animals studied, values for PGC remained at, or slightly below, levels measured before PAN or ADM administration. SNGFR values declined progressively in all glomeruli in PAN rats. Although some glomeruli in ADM rats had an increase in SNGFR above levels observed in nonnephrectomized control rats, these hyperfiltering glomeruli did not have abnormally high PGC nor did they exhibit glomerular sclerosis at the completion of the study. Histological analysis revealed the existence of a significant inverse correlation between the degree of sclerosis and SNGFR assessed at the time of sacrifice in both PAN and ADM groups. Chronic administration of captopril, an angiotensin I converting enzyme inhibitor, in PAN rats substantially attenuated development of glomerular sclerosis without affecting PGC in earlier stages. The observations in these models indicate that glomerular hyperfiltration and hypertension are not required for the development of glomerular sclerosis in renal diseases, and angiotensin I converting enzyme inhibitor can exert its protective effect independently of its effect on glomerular capillary pressure.
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17 MeSH Terms
Microarteriorrhaphy: blood flow after wound healing.
Blair WF, Pedersen DR, Joos K, Green ER, Bondi D
(1985) Microsurgery 6: 116-20
MeSH Terms: Animals, Femoral Artery, Microsurgery, Rats, Rheology, Suture Techniques, Wound Healing
Show Abstract · Added March 19, 2018
The present study tests the hypothesis that early wound healing effects blood flow after experimental microarteriorrhaphy. Hemodynamic variables were measured in the rat femoral artery prior to and 3 weeks after both interrupted and continuous microarteriorrhaphy techniques. The hemodynamic variables (blood velocities, lumen geometry, and calculated blood flow) were measured by 20-MHz pulsed ultrasonic Doppler velocity meter (PUDVM) methods. The control values (N = 22) and the 3 weeks postoperative values, for both the interrupted (N = 11) and continuous groups (N = 11), were not statistically different (P greater than .01). The average calculated blood flows were as follows: control group 10.85 +/- 1.45 cc/min, interrupted group 12.01 +/- .92 cc/min, and continuous group 8.50 +/- 1.45 cc/min. Three weeks of wound healing after microarteriorrhaphy did not significantly change blood flow variables compared to preoperative values.
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7 MeSH Terms
Treatment of cervical intraepithelial neoplasia.
Jones HW
(1990) Clin Obstet Gynecol 33: 826-36
MeSH Terms: Biopsy, Cautery, Cryosurgery, Female, Humans, Hysterectomy, Laser Therapy, Uterine Cervical Neoplasms
Added March 5, 2014
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8 MeSH Terms