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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 16041 to 16050 of 16081

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Interaction of bovine platelets with bovine glomerular basement membrane.
Davis JL, Chandler DK, Riquetti P, Rogers S, Kocan KM, Ownby CL, Hudson BG, Carraway KL
(1979) Thromb Haemost 42: 1217-29
MeSH Terms: Animals, Basement Membrane, Blood Platelets, Calcium, Cattle, Female, Kidney Glomerulus, Platelet Adhesiveness, Platelet Aggregation, Serotonin
Show Abstract · Added December 10, 2013
The interaction of bovine platelets with bovine glomerular basement membrane has been studied by aggregometry, transmission and scanning electron microscopy and measurement of [3H] serotonin release. In the absence of added calcium platelets adhere to basement membrane but fail to undergo the release reaction or aggregation. In the presence of 0.2-0.5 mM calcium release of serotonin and complete aggregation of the platelets are observed when sufficient basement membrane is present. Platelets were strongly adhered to the basement membrane surface, the platelet surface in the aggregates closely following the surface of the basement membrane. Platelet morphology in aggregates with basement membrane closely resembled that of platelets from collagen-induced aggregates. Basement membrane differed from collagen in its requirement for calcium for the aggregation and release reactions. In addition purified basement membrane was 1.5-3 fold less active on a weight basis than bovine tendon collagen in promoting aggregation.
1 Communities
1 Members
0 Resources
10 MeSH Terms
Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man.
Liljenquist JE, Bloomgarden ZT, Cherrington AD, Perry JM, Rabin D
(1979) Diabetologia 17: 139-43
MeSH Terms: Adolescent, Adult, Glucagon, Glucose, Glucose Tolerance Test, Humans, Hyperglycemia, Insulin, Male, Somatostatin
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
Survival in medically treated coronary artery disease.
Harris PJ, Harrell FE, Lee KL, Behar VS, Rosati RA
(1979) Circulation 60: 1259-69
MeSH Terms: Cardiac Catheterization, Coronary Disease, Electrocardiography, Female, Heart Ventricles, Hemodynamics, Humans, Male, Pain, Prognosis, Risk, Thorax
Added February 28, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Severe hypercalcemia associated with hydrochlorothiazide and calcium carbonate therapy.
Hakim R, Tolis G, Goltzman D, Meltzer S, Friedman R
(1979) Can Med Assoc J 121: 591-4
MeSH Terms: Aged, Antacids, Calcium Carbonate, Diagnosis, Differential, Female, Furosemide, Hormones, Humans, Hydrochlorothiazide, Hydrocortisone, Hypercalcemia, Hyperparathyroidism, Potassium Chloride, Sodium Chloride
Added May 20, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Effect of phenobarbital administration to rats on the level of the in vitro synthesis of cytochrome P-450 directed by total rat liver RNA.
Dubois RN, Waterman MR
(1979) Biochem Biophys Res Commun 90: 150-7
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Kinetics, Liver, Male, Molecular Weight, Phenobarbital, Protein Biosynthesis, RNA, Rats
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression.
Guyette WA, Matusik RJ, Rosen JM
(1979) Cell 17: 1013-23
MeSH Terms: Animals, Caseins, Female, Genes, Mammary Glands, Animal, Organ Culture Techniques, Pregnancy, Prolactin, RNA, Messenger, Rats, Time Factors, Transcription, Genetic
Show Abstract · Added June 11, 2010
The mechanism by which prolactin, a peptide hormone, regulates casein gene expression has been studied in mammary gland organ culture. After prolactin addition, a 2-4 fold increase in the rate of casein mRNA transcription was observed within 1 hr and maintained for at least 24 hr. This increased rate of transcription is not sufficient to account for the mass accumulation of casein mRNA. The half-life of casein mRNA is also increased 17-25 fold in the presence of prolactin. This change in casein mRNA half-life, coupled with a 2-4 fold increase in the rate of transcription, can account for the normal accumulation of casein mRNA observed after prolactin addition. This hormone-induced change in casein mRNA half-life appeared to be selective, since prolactin was found to exert only a slight effect (1-4 fold) on the half-life of poly(A) RNA determined under identical pulse-chase conditions. The hormonal regulation of casein gene expression thus does not app-ar to be an "all or none" process occurring only at the transcriptional or post-transcriptional levels, but rather may involve a coordinated response at several levels to permit the efficient expression of specialized differentiated functions.
1 Communities
1 Members
0 Resources
12 MeSH Terms
Reduction of serum cholesterol in two patients with homozygous familial hypercholesterolemia by dichloroacetate.
Moore GW, Swift LL, Rabinowitz D, Crofford OB, Oates JA, Stacpoole PW
(1979) Atherosclerosis 33: 285-93
MeSH Terms: Acetates, Acrodynia, Adult, Child, Cholesterol, Dichloroacetic Acid, Humans, Hypercholesterolemia, Male, Xanthomatosis
Show Abstract · Added May 27, 2014
Dichloroacetate is known to reduce plasma cholesterol and triglyceride in patients with Fredrickson Types IIb or IV hyperlipoproteinemia. We now report the effects of chronic, oral dichloroacetate administration (as the sodium salt) in two patients with severe homozygous familial hypercholesterolemia. Dichloroacetate markedly reduced serum total and low density lipoprotein cholesterol levels and lowered the low density lipoprotein to high density lipoprotein cholesterol ratio. One patient developed a polyneuropathy while receiving dichloroacetate which resolved following discontinuation of the drug. Because of its apparent toxicity, dichloroacetate cannot be recommended for chronic oral use. Investigation of the mechanism of its lipid-lowering effect, however, may provide insight into the pathogenesis and treatment of hypercholesterolemic disorders.
0 Communities
1 Members
0 Resources
10 MeSH Terms
Studies on the transport mechanism of 5-methyltetrahydrofolic acid in freshly isolated hepatocytes: effect of ethanol.
Horne DW, Briggs WT, Wagner C
(1979) Arch Biochem Biophys 196: 557-65
MeSH Terms: Alcohols, Anaerobiosis, Animals, Azides, Biological Transport, Ethanol, In Vitro Techniques, Kinetics, Liver, Male, Methotrexate, Pyrazoles, Rats, Structure-Activity Relationship, Tetrahydrofolates
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Radiosensitivity and recovery from radiation damage in cultured CHO cells exposed to hyperthermia at 42.5 or 45.5 degrees C.
Raaphorst GP, Freeman ML, Dewey WC
(1979) Radiat Res 79: 390-402
MeSH Terms: Animals, Cell Line, Cell Survival, Cricetinae, DNA Repair, Dose-Response Relationship, Radiation, Female, Hot Temperature, Ovary, Time Factors, X-Rays
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Methemoglobinemia from sniffing butyl nitrite.
Horne MK, Waterman MR, Simon LM, Garriott JC, Foerster EH
(1979) Ann Intern Med 91: 417-8
MeSH Terms: Adult, Cytochrome-B(5) Reductase, Half-Life, Humans, Kinetics, Male, Methemoglobinemia, NADH, NADPH Oxidoreductases, Nitrites, Substance-Related Disorders
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms