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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 131 to 140 of 140

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A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
Elsea SH, Hsiung Y, Nitiss JL, Osheroff N
(1995) J Biol Chem 270: 1913-20
MeSH Terms: Amino Acid Sequence, Animals, Anti-Infective Agents, DNA Topoisomerases, Type II, Drug Resistance, Ellipticines, Fluoroquinolones, Histidine, Humans, Kinetics, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, Point Mutation, Quinolones, Recombinant Proteins, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, Topoisomerase II Inhibitors, Tyrosine
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation.
Sumi S, Beauchamp RD, Townsend CM, Pour PM, Ishizuka J, Thompson JC
(1994) Pancreas 9: 657-61
MeSH Terms: Animals, Base Sequence, Cell Division, Cricetinae, Genes, ras, Humans, Lovastatin, Molecular Sequence Data, Pancreatic Neoplasms, Point Mutation
Added May 3, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.
Hsiung Y, Elsea SH, Osheroff N, Nitiss JL
(1995) J Biol Chem 270: 20359-64
MeSH Terms: Anti-Infective Agents, Base Sequence, DNA Topoisomerases, Type II, Drug Resistance, Microbial, Escherichia coli, Etoposide, Fluoroquinolones, Genes, Bacterial, Genes, Fungal, Kinetics, Macromolecular Substances, Molecular Sequence Data, Mutagenesis, Site-Directed, Oligodeoxyribonucleotides, Point Mutation, Quinolones, Recombinant Proteins, Saccharomyces cerevisiae, Serine, Species Specificity, Tryptophan
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
A central role for a single c-Myb binding site in a thymic locus control region.
Ess KC, Whitaker TL, Cost GJ, Witte DP, Hutton JJ, Aronow BJ
(1995) Mol Cell Biol 15: 5707-15
MeSH Terms: Adenosine Deaminase, Animals, Base Sequence, Binding Sites, Cell Line, Chromatin, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Humans, Introns, Mice, Mice, Transgenic, Molecular Sequence Data, Point Mutation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-myb, Saccharomyces cerevisiae, T-Lymphocytes, Thymus Gland, Trans-Activators
Added June 9, 2010
0 Communities
1 Members
0 Resources
20 MeSH Terms
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL
(1995) Nat Genet 11: 447-9
MeSH Terms: Alternative Splicing, Amino Acid Sequence, Animals, Base Sequence, Carcinoma, Hepatocellular, Cattle, DNA Mutational Analysis, Extracellular Space, Genes, Tumor Suppressor, Heterozygote, Humans, Liver Neoplasms, Mice, Molecular Sequence Data, Point Mutation, Rats, Receptor, IGF Type 2
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Expression and regulation of clonally ignorant B cells.
Thomas JW, Hulbert C
(1995) Ann N Y Acad Sci 764: 461-2
MeSH Terms: Animals, Antibodies, Monoclonal, Antibody Affinity, Antigen-Antibody Reactions, Autoantibodies, B-Lymphocyte Subsets, Clonal Anergy, Clonal Deletion, Diabetes Mellitus, Genes, Immunoglobulin, Genetic Vectors, Immunization, Immunoglobulin Constant Regions, Immunoglobulin G, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Insulin, Mice, Mice, Inbred BALB C, Mutagenesis, Site-Directed, Point Mutation, Recombinant Fusion Proteins
Added November 6, 2013
1 Communities
0 Members
0 Resources
22 MeSH Terms
The ability to associate with activation domains in vitro is not required for the TATA box-binding protein to support activated transcription in vivo.
Tansey WP, Herr W
(1995) Proc Natl Acad Sci U S A 92: 10550-4
MeSH Terms: DNA-Binding Proteins, Herpes Simplex Virus Protein Vmw65, Humans, Models, Molecular, Point Mutation, Protein Binding, Structure-Activity Relationship, TATA-Box Binding Protein, Transcription Factors, Transcription, Genetic, Tumor Suppressor Protein p53
Added March 10, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA.
Starr L, Quaranta V
(1992) Biotechniques 13: 612-8
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, DNA Polymerase I, Humans, Integrins, Mice, Molecular Sequence Data, Point Mutation, Polymerase Chain Reaction, Polynucleotide 5'-Hydroxyl-Kinase, Rats, Sequence Alignment, Sequence Homology, Nucleic Acid
Added March 27, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms
A rapid and simple procedure for the routine detection of ras point mutations in formalin-fixed, paraffin-embedded tissues.
Slebos RJ, Boerrigter L, Evers SG, Wisman P, Mooi WJ, Rodenhuis S
(1992) Diagn Mol Pathol 1: 136-41
MeSH Terms: Base Sequence, DNA, Neoplasm, Evaluation Studies as Topic, Formaldehyde, Genes, ras, Histological Techniques, Humans, Molecular Sequence Data, Neoplasms, Oligonucleotide Probes, Paraffin, Point Mutation, Polymerase Chain Reaction
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
The ras gene family in human non-small-cell lung cancer.
Slebos RJ, Rodenhuis S
(1992) J Natl Cancer Inst Monogr : 23-9
MeSH Terms: Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Gene Expression Regulation, Neoplastic, Genes, ras, Humans, Lung Neoplasms, Point Mutation, Smoking
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms