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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 131 to 140 of 142

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Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate.
Gale KC, Osheroff N
(1990) Biochemistry 29: 9538-45
MeSH Terms: Animals, Base Sequence, DNA Topoisomerases, Type II, DNA, Single-Stranded, DNA, Viral, Drosophila melanogaster, Embryo, Nonmammalian, Kinetics, Molecular Sequence Data, Oligodeoxyribonucleotides, Phosphorus Radioisotopes, Protein Binding, Radioisotope Dilution Technique, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers.
Zechiedrich EL, Osheroff N
(1990) EMBO J 9: 4555-62
MeSH Terms: Animals, Cell Nucleus, DNA, DNA Topoisomerases, Type I, DNA Topoisomerases, Type II, Drosophila melanogaster, Nucleic Acid Conformation
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
Robinson MJ, Osheroff N
(1990) Biochemistry 29: 2511-5
MeSH Terms: Aminacrine, Aminoacridines, Amsacrine, Animals, Antineoplastic Agents, Culture Techniques, DNA, DNA Damage, DNA Polymerase II, DNA Topoisomerases, Type II, Drosophila melanogaster, Enzyme Stability
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.
Robinson MJ, Osheroff N
(1991) Biochemistry 30: 1807-13
MeSH Terms: Adenylyl Imidodiphosphate, Amsacrine, Animals, DNA, DNA Topoisomerases, Type II, Drosophila melanogaster, Etoposide, Hydrolysis, Kinetics
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Catalytic function of DNA topoisomerase II.
Osheroff N, Zechiedrich EL, Gale KC
(1991) Bioessays 13: 269-73
MeSH Terms: Adenosine Triphosphate, Animals, Antineoplastic Agents, Base Sequence, Catalysis, Consensus Sequence, DNA, DNA Topoisomerases, Type II, DNA, Superhelical, Eukaryotic Cells, Humans, Molecular Sequence Data, Nucleic Acid Conformation, Phosphorylation, Protein Binding, Recombination, Genetic, Substrate Specificity, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.
Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Moynihan M, Sutcliffe JA, Osheroff N
(1991) J Biol Chem 266: 14585-92
MeSH Terms: Animals, Anti-Infective Agents, Catalysis, Cell Line, Cell Survival, Cricetinae, Cricetulus, DNA, DNA Topoisomerases, Type II, Drosophila melanogaster, Electrophoresis, Agar Gel, Etoposide, Fluoroquinolones, Hydrolysis, Molecular Structure, Quinolones
Added February 20, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Effect of casein kinase II-mediated phosphorylation on the catalytic cycle of topoisomerase II. Regulation of enzyme activity by enhancement of ATP hydrolysis.
Corbett AH, DeVore RF, Osheroff N
(1992) J Biol Chem 267: 20513-8
MeSH Terms: Adenosine Triphosphate, Animals, Casein Kinase II, Catalysis, DNA, DNA Topoisomerases, Type II, Drosophila melanogaster, Hydrolysis, Phosphorylation, Protein Serine-Threonine Kinases
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group.
Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N
(1992) Antimicrob Agents Chemother 36: 751-6
MeSH Terms: Animals, Anti-Infective Agents, CHO Cells, Cricetinae, DNA, DNA Topoisomerases, Type II, Dose-Response Relationship, Drug, Drosophila melanogaster, Electrophoresis, Agar Gel, Fluoroquinolones, In Vitro Techniques, Quinolones
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.
Elsea SH, Osheroff N, Nitiss JL
(1992) J Biol Chem 267: 13150-3
MeSH Terms: Anti-Infective Agents, Cell Survival, DNA Damage, DNA Topoisomerases, Type II, Fluoroquinolones, Mutation, Quinolones, Saccharomyces cerevisiae, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination.
Gale KC, Osheroff N
(1992) J Biol Chem 267: 12090-7
MeSH Terms: Adenosine Triphosphate, Animals, Autoradiography, Bacteriophage phi X 174, Base Sequence, Blotting, Southern, Cations, Divalent, DNA Topoisomerases, Type II, DNA, Viral, Drosophila melanogaster, Molecular Sequence Data, Nucleic Acid Conformation, Recombination, Genetic, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms