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Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.
Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, van Heyningen V, Jessell TM, Briscoe J
(1997) Cell 90: 169-80
MeSH Terms: Animals, Chick Embryo, DNA-Binding Proteins, Embryonic Induction, Eye Proteins, Hedgehog Proteins, Homeodomain Proteins, Interneurons, Motor Neurons, Nervous System, Neurons, Organ Culture Techniques, PAX6 Transcription Factor, Paired Box Transcription Factors, Proteins, Repressor Proteins, Rhombencephalon, Signal Transduction, Spinal Cord, Stem Cells, Trans-Activators, Transcription Factors, Zebrafish Proteins
Show Abstract · Added July 30, 2010
Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
0 Communities
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1 Resources
23 MeSH Terms
Ultrasound backscatter microscope analysis of early mouse embryonic brain development.
Turnbull DH, Bloomfield TS, Baldwin HS, Foster FS, Joyner AL
(1995) Proc Natl Acad Sci U S A 92: 2239-43
MeSH Terms: Animals, Brain, Embryonic and Fetal Development, Female, Heart, Mice, Microscopy, Mutation, Myocardium, Neural Tube Defects, Phenotype, Pregnancy, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Proto-Oncogenes, Rhombencephalon, Ultrasonics, Wnt Proteins, Wnt1 Protein, Zebrafish Proteins
Show Abstract · Added June 11, 2010
The history of developmental and genetic analysis in the mouse has made it the model of choice for studying mammalian embryogenesis. Presently lacking is a simple technique for efficiently analyzing early mouse mutant phenotypes in utero. We demonstrate application of a real-time imaging method called ultrasound backscatter microscopy for visualizing mouse early embryonic neural tubes and hearts. This method was used to study live embryos in utero between 9.5 and 11.5 days of embryogenesis, with a spatial resolution close to 50 microns. Ultrasound backscatter microscope images of cultured embryos made it possible to visualize the heart chambers. This noninvasive imaging method was also used for analyzing a neural tube defect. The midhindbrain deletion associated with a null mutation of the Wnt-1 protooncogene was easily recognizable on ultrasound backscatter microscope images of 10.5- and 11.5-day embryos. Computer-generated volumetric renderings of the neural tube cavities were made from three-dimensional image data. This allowed a much clearer definition of the Wnt-1 mutant phenotype. These imaging techniques should be of considerable use in studying mouse development in utero.
1 Communities
1 Members
0 Resources
20 MeSH Terms
Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish.
Toyama R, O'Connell ML, Wright CV, Kuehn MR, Dawid IB
(1995) Development 121: 383-91
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, DNA-Binding Proteins, Embryonic Induction, Gene Expression, Genes, Homeobox, Goosecoid Protein, Homeodomain Proteins, In Situ Hybridization, Mesoderm, Microinjections, Molecular Sequence Data, Morphogenesis, RNA, Messenger, Repressor Proteins, Transcription Factors, Zebrafish, Zebrafish Proteins
Show Abstract · Added June 11, 2010
One of the first intercellular signalling events in the vertebrate embryo leads to mesoderm formation and axis determination. In the mouse, a gene encoding a new member of the TGF-beta superfamily, nodal, is disrupted in a mutant deficient in mesoderm formation (Zhou et al., 1993, Nature 361, 543). nodal mRNA is found in prestreak mouse embryos, consistent with a role in the development of the dorsal axis. To examine the biological activities of nodal, we have studied the action of this factor in eliciting axis determination in the zebrafish, Danio rerio. Injection of nodal mRNA into zebrafish embryos caused the formation of ectopic axes that included notochord and somites. Axis duplication was preceded by the generation of an apparent ectopic shield (organizer equivalent) in nodal-injected embryos, as indicated by the appearance of a region over-expressing gsc and lim1; isolation and expression in the shield of the lim1 gene is reported here. These results suggest a role for a nodal-like factor in pattern formation in zebrafish.
1 Communities
1 Members
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20 MeSH Terms