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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 121 to 130 of 132

Publication Record

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Emerging molecular classification in renal cell carcinoma: implications for drug development.
Hacker KE, Rathmell WK
(2010) Target Oncol 5: 75-84
MeSH Terms: Carcinoma, Renal Cell, Drug Discovery, Drug Therapy, Evidence-Based Medicine, Humans, Kidney Neoplasms, Patient Selection, Precision Medicine
Added October 17, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.
Bhave G, Lonergan D, Chauder BA, Denton JS
(2010) Future Med Chem 2: 757-74
MeSH Terms: Animals, Drug Discovery, Humans, Models, Molecular, Potassium Channels, Inwardly Rectifying, Small Molecule Libraries
Added March 24, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Melanoma from bench to bedside: meeting report from the 6th international melanoma congress.
Fisher DE, Barnhill R, Hodi FS, Herlyn M, Merlino G, Medrano E, Bastian B, Landi MT, Landi TM, Sosman J
(2010) Pigment Cell Melanoma Res 23: 14-26
MeSH Terms: Animals, Biomedical Research, Clinical Trials as Topic, Cooperative Behavior, Disease Models, Animal, Drug Discovery, Humans, Immunity, Innate, Interdisciplinary Communication, Melanocytes, Melanoma, Molecular Biology, Pathology, Signal Transduction, Translational Research, Biomedical
Added March 20, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Targeting the transforming growth factor-beta signaling pathway in human cancer.
Nagaraj NS, Datta PK
(2010) Expert Opin Investig Drugs 19: 77-91
MeSH Terms: Antineoplastic Agents, Clinical Trials as Topic, Drug Discovery, Humans, Neoplasms, Oligonucleotides, Antisense, Signal Transduction, Small Molecule Libraries, Transforming Growth Factor beta
Added June 14, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms
Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Felts AS, Saleh SA, Le U, Rodriguez AL, Weaver CD, Conn PJ, Lindsley CW, Emmitte KA
(2009) Bioorg Med Chem Lett 19: 6623-6
MeSH Terms: Animals, Cell Line, Drug Design, Drug Discovery, Humans, Molecular Structure, Quinazolines, Rats, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Stereoisomerism, Structure-Activity Relationship
Added February 16, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.
Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW
(2009) Curr Top Med Chem 9: 1217-26
MeSH Terms: Drug Discovery, High-Throughput Screening Assays, Receptor, Muscarinic M1, Substrate Specificity, Sulfonamides, Thiadiazoles
Added February 16, 2015
0 Communities
3 Members
0 Resources
6 MeSH Terms
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.
Rodriguez AL, Williams R, Zhou Y, Lindsley SR, Le U, Grier MD, Weaver CD, Conn PJ, Lindsley CW
(2009) Bioorg Med Chem Lett 19: 3209-13
MeSH Terms: Allosteric Regulation, Drug Discovery, Heterocyclic Compounds, 3-Ring, Humans, Inhibitory Concentration 50, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added March 5, 2014
1 Communities
3 Members
0 Resources
8 MeSH Terms
Targeting protein serine/threonine phosphatases for drug development.
McConnell JL, Wadzinski BE
(2009) Mol Pharmacol 75: 1249-61
MeSH Terms: Animals, Antineoplastic Agents, Catalytic Domain, Drug Discovery, Enzyme Activation, Humans, Immunosuppressive Agents, Multiprotein Complexes, Phosphoprotein Phosphatases, Phosphorylation, Protein Tyrosine Phosphatases
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.
Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD
(2009) Proc Natl Acad Sci U S A 106: 5383-8
MeSH Terms: Binding, Competitive, Cell Line, Drug Discovery, Humans, Neurons, Small Molecule Libraries, Structure-Activity Relationship, Symporters
Added March 5, 2014
1 Communities
2 Members
0 Resources
8 MeSH Terms
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
Conn PJ, Lindsley CW, Jones CK
(2009) Trends Pharmacol Sci 30: 25-31
MeSH Terms: Allosteric Regulation, Animals, Drug Delivery Systems, Drug Discovery, Humans, Models, Theoretical, Receptors, Metabotropic Glutamate, Schizophrenia
Added March 5, 2014
1 Communities
2 Members
0 Resources
8 MeSH Terms