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Results: 111 to 113 of 113

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Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).
Wall NA, Blessing M, Wright CV, Hogan BL
(1993) J Cell Biol 120: 493-502
MeSH Terms: Animals, Bone Morphogenetic Proteins, Cattle, Cells, Cultured, Embryo, Mammalian, Embryonic and Fetal Development, Epithelial Cells, Epithelium, Female, Glutathione Transferase, Growth Substances, Humans, Immunohistochemistry, Mammary Glands, Animal, Mice, Nervous System, Protein Biosynthesis, Proteins, Recombinant Fusion Proteins, Transcription, Genetic, Transfection
Show Abstract · Added June 11, 2010
DVR-6 (BMP-6 or Vgr-1) is a member of the TGF-beta superfamily of polypeptide signaling molecules. In situ hybridization studies have previously shown that DVR-6 RNA is expressed in a variety of cell types in the mouse embryo, but no information has been available on protein localization and biosynthesis. We have produced a polyclonal antibody to the proregion of DVR-6 and used it to localize the protein in whole mount and sectioned embryonic, newborn, and adult mouse tissues. DVR-6 protein is expressed in the mouse nervous system beginning at 9.5 days postcoitum (d.p.c.) and continues through adulthood. A variety of epithelial tissues also produce DVR-6 protein, including the suprabasal layer of the skin, bronchiolar epithelium, and the cornea. Additionally, a stably transfected cell line, BMGE+H/D6c4, is used to study the biosynthesis of DVR-6 protein and evidence is presented for translational regulation of DVR-6 expression.
1 Communities
1 Members
0 Resources
21 MeSH Terms
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
Winnier G, Blessing M, Labosky PA, Hogan BL
(1995) Genes Dev 9: 2105-16
MeSH Terms: Animals, Base Sequence, Bone Morphogenetic Proteins, Cell Line, Chimera, Crosses, Genetic, Embryonic and Fetal Development, Female, Gastrula, Gene Targeting, Heterozygote, Homozygote, Male, Mesoderm, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Phenotype, Proteins, Stem Cells
Show Abstract · Added July 20, 2010
Bone morphogenetic protein-4 (BMP-4) is a member of the TGF-beta superfamily of polypeptide signaling molecules, closely related to BMP-2 and to Drosophila decapentaplegic (DPP). To elucidate the role of BMP-4 in mouse development the gene has been inactivated by homologous recombination in ES cells. Homozygous mutant Bmp-4tm1blh embryos die between 6.5 and 9.5 days p.c., with a variable phenotype. Most Bmp-4tm1blh embryos do not proceed beyond the egg cylinder stage, do not express the mesodermal marker T(Brachyury), and show little or no mesodermal differentiation. Some homozygous mutants develop to the head fold or beating heart/early somite stage or beyond. However, they are developmentally retarded and have truncated or disorganized posterior structures and a reduction in extraembryonic mesoderm, including blood islands. These results provide direct genetic evidence that BMP-4 is essential for several different processes in early mouse development, beginning with gastrulation and mesoderm formation. Moreover, in the presumed absence of zygotic ligand, it appears that homozygous mutants can be rescued partially by related proteins or by maternal BMP-4.
1 Communities
1 Members
0 Resources
20 MeSH Terms
DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
Jones CM, Lyons KM, Lapan PM, Wright CV, Hogan BL
(1992) Development 115: 639-47
MeSH Terms: Activins, Animals, Base Sequence, Bone Morphogenetic Proteins, Embryo, Nonmammalian, Embryonic Induction, Gene Expression, Growth Substances, Inhibins, Mesoderm, Microinjections, Molecular Sequence Data, Morphogenesis, Proteins, Xenopus laevis
Show Abstract · Added June 11, 2010
Establishment of mesodermal tissues in the amphibian body involves a series of inductive interactions probably elicited by a variety of peptide growth factors. Results reported here suggest that mesodermal patterning involves an array of signalling molecules including DVR-4, a TGF-beta-like molecule. We show that ectopic expression of DVR-4 causes embryos to develop with an overall posterior and/or ventral character, and that DVR-4 induces ventral types of mesoderm in animal cap explants. Moreover, DVR-4 overrides the dorsalizing effects of activin. DVR-4 is therefore the first molecule reported both to induce posteroventral mesoderm and to counteract dorsalizing signals such as activin. Possible interactions between these molecules resulting in establishment of the embryonic body plan are discussed.
1 Communities
1 Members
0 Resources
15 MeSH Terms