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Results: 101 to 103 of 103

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Changes in cellular heat and/or radiation sensitivity observed at various times after trypsinization and plating.
Raaphorst GP, Sapareto SA, Freeman ML, Dewey WC
(1979) Int J Radiat Biol Relat Stud Phys Chem Med 35: 193-7
MeSH Terms: Animals, Cell Survival, Cells, Cultured, Cricetinae, Cricetulus, Cytological Techniques, Hot Temperature, Radiation Tolerance, Time Factors, Trypsin, X-Rays
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Collagen-mediated platelet aggregation. Evidence for multivalent interactions of intermediate specificity between collagen and platelets.
Santoro SA, Cunningham LW
(1977) J Clin Invest 60: 1054-60
MeSH Terms: Amino Acids, Animals, Borohydrides, Carbohydrates, Chemical Phenomena, Chemistry, Collagen, Hot Temperature, Humans, In Vitro Techniques, Oxidation-Reduction, Periodic Acid, Platelet Aggregation, Protein Denaturation, Rats, Skin, Sodium Chloride, Solubility
Show Abstract · Added March 5, 2014
We have shown previously that periodate oxidation of collagen carbohydrate does not affect its ability to aggregate platelets. We now describe an additional characterization of periodate-modified collagen which demonstrates that collagen devoid of intact carbohydrate is fully capable of fibril formation, and we confirm its capacity to initiate platelet aggregation. Furthermore, we demonstrate that the platelet aggregating abilities of Types I, II, and III fibrillar collagen are quite similar despite differences in carbohydrate content and amino acid sequence. We also demonstrate that monomeric, pepsin-solubilized Type I human collagen is ineffective inhibiting aggregation by performed fibrils derived from the same molecule, thus establishing that the affinity of platelets for collagen depends upon prior polymerization of collagen. We interpret these and other findings to demonstrate that the hydroxylysyl glycoside regions of collagen are not highly specific sites involved in platelet-collagen interactions leading to "physiological" aggregation, and that the possibility must be considered that multiple interactions involving collagen sites of comparatively low structural specificity may be the initiating events in release of platelet ADP and the ensuing aggregation.
1 Communities
1 Members
0 Resources
18 MeSH Terms
Effect of pH on hyperthermic cell survival.
Freeman ML, Dewey WC, Hopwood LE
(1977) J Natl Cancer Inst 58: 1837-9
MeSH Terms: Cell Survival, Cells, Cultured, Hot Temperature, Hydrogen-Ion Concentration, Hyperthermia, Induced, Neoplasms
Show Abstract · Added March 5, 2014
Chinese hamster ovary cells incubated with various concentrations of CO2, to obtain extracellular pH values in the range of 6.40-7.85, were heated at 45.5C for 5, 10, or 20 minutes. Thermal sensitivity increased sharply from pH 7.35 to 6.65 (i.e., survival decreased from 1 X 10(-2) to 3 X 10(-5) for 20 minutes of heating), but remained constant from pH 7.35 to 7.85. The enhanced thermal sensitivity at pH values below pth 7.35 suggested that tumors should be preferentially destroyed by heat relative to normal tissue, since reports indicated that tumors were more acidic than the surrounding normal tissue.
0 Communities
1 Members
0 Resources
6 MeSH Terms