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Results: 101 to 103 of 103

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.
Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC
(1995) Science 269: 230-4
MeSH Terms: Abnormalities, Multiple, Animals, Base Sequence, Brain, Cell Division, Digestive System, Digestive System Abnormalities, Embryonic and Fetal Development, ErbB Receptors, Female, Gene Targeting, Hair, Homozygote, Kidney, Lung, Male, Mice, Molecular Sequence Data, Mutation, Phenotype, Skin, Skin Abnormalities
Show Abstract · Added January 28, 2014
Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
1 Communities
1 Members
0 Resources
22 MeSH Terms
Chromosomal position effects and the modulation of transgene expression.
Clark AJ, Bissinger P, Bullock DW, Damak S, Wallace R, Whitelaw CB, Yull F
(1994) Reprod Fertil Dev 6: 589-98
MeSH Terms: Animals, Chromosomes, DNA, Recombinant, Embryo, Mammalian, Gene Expression, Gene Targeting, Gene Transfer Techniques, Humans, Stem Cells
Show Abstract · Added February 19, 2015
Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.
0 Communities
1 Members
0 Resources
9 MeSH Terms
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.
Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BL, Inagami T
(1995) Nature 377: 748-50
MeSH Terms: Angiotensin II, Animals, Blood Pressure, Body Temperature, Cell Line, Crosses, Genetic, Exploratory Behavior, Female, Gene Targeting, Male, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Receptors, Angiotensin, Vasoconstrictor Agents
Show Abstract · Added January 20, 2012
There are two major angiotensin II receptor isoforms, AT1 and AT2. AT1 mediates the well-known pressor and mitogenic effects of angiotensin II, but the signalling mechanism and physiological role of AT2 has not been established. Its abundant expression in fetal tissues and certain brain nuclei suggest possible roles in growth, development and neuronal functions. Here we report the unexpected finding that the targeted disruption of the mouse AT2 gene resulted in a significant increase in blood pressure and increased sensitivity to the pressor action of angiotensin II. Thus AT2 mediates a depressor effect and antagonizes the AT1-mediated pressor action of angiotensin II. In addition, disruption of the AT2 gene attenuated exploratory behaviour and lowered body temperature. Our results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemodynamic effects, and that AT2 regulates central nervous system functions, including behaviour.
2 Communities
2 Members
0 Resources
15 MeSH Terms