Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 91 to 97 of 97

Publication Record

Connections

Linkage analysis with adjustment for covariates: a method combining peeling with Gibbs sampling.
Kong A, Frigge M, Cox N, Wong WH
(1992) Cytogenet Cell Genet 59: 208-10
MeSH Terms: Data Interpretation, Statistical, Dysplastic Nevus Syndrome, Genetic Linkage, Humans, Mathematics, Sampling Studies, Skin Neoplasms
Added February 22, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Importance sampling. I. Computing multimodel p values in linkage analysis.
Kong A, Frigge M, Irwin M, Cox N
(1992) Am J Hum Genet 51: 1413-29
MeSH Terms: Diabetes Mellitus, Type 2, Female, Genetic Linkage, Genetic Markers, Humans, Lod Score, Male, Mathematics, Monte Carlo Method, Pedigree, Software
Show Abstract · Added February 22, 2016
In linkage analysis, when the lod score is maximized over multiple genetic models, standard asymptotic approximation of the significance level does not apply. Monte Carlo methods can be used to estimate the p value, but procedures currently used are extremely inefficient. We propose a Monte Carlo procedure based on the concept of importance sampling, which can be thousands of times more efficient than current procedures. With a reasonable amount of computing time, extremely accurate estimates of the p values can be obtained. Both theoretical results and an example of maturity-onset diabetes of the young (MODY) are presented to illustrate the efficiency performance of our method. Relations between single-model and multimodel p values are explored. The new procedure is also used to investigate the performance of asymptotic approximations in a single model situation.
0 Communities
1 Members
0 Resources
11 MeSH Terms
Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog.
Pagliassotti MJ, Moore MC, Neal DW, Cherrington AD
(1992) Diabetes 41: 1247-56
MeSH Terms: Alanine, Analysis of Variance, Animals, Blood Glucose, C-Peptide, Dogs, Fatty Acids, Nonesterified, Female, Glucagon, Glucose, Glycerol, Insulin, Kinetics, Lactates, Liver, Male, Mathematics, Models, Biological, Pancreatectomy, Portal System
Show Abstract · Added December 10, 2013
To determine whether insulin is essential for the augmented hepatic glucose uptake observed in the presence of intraportal glucose delivery, SRIF was used to induce acute insulin deficiency in 5 conscious dogs, and glucose was infused into the portal vein or a peripheral vein in two sequential, randomized periods. Insulin and C-peptide levels were below the limits of detection after SRIF infusion, and the load of glucose presented to the liver was approximately doubled and equivalent during the portal and peripheral periods. Net hepatic glucose output was 2.9 +/- 0.9 and 2.1 +/- 1.1 mumol.kg-1.min-1 during portal and peripheral glucose delivery, respectively. In an additional set of protocols, pancreatectomized dogs were used to investigate the effects of prolonged insulin deficiency (n = 5) and acute insulin replacement (n = 4) on the hepatic response to intraportal glucose delivery. In the prolonged insulin deficiency protocol, SRIF was used to lower glucagon and thereby reduce circulating glucose levels, and glucose was infused into the portal or peripheral circulations in two sequential, randomized periods. As with acute insulin deficiency, net hepatic glucose output was still evident and similar (3.6 +/- 1.1 and 4.2 +/- 1.3 mumol.kg-1.min-1) during portal and peripheral glucose delivery, respectively. When the pancreatectomized dogs were restudied using a similar protocol, but one in which insulin was replaced (4X-basal), and the glucose load to the liver was matched to that which occurred in the prolonged insulin deficiency protocol, net hepatic glucose uptake was 23.6 +/- 6.1 mumol.kg-1.min-1 during portal glucose delivery but only 10.3 +/- 3.5 mumol.kg-1.min-1 during peripheral glucose delivery. These results suggest that the induction of net hepatic glucose uptake and the augmented hepatic response to intraportal glucose delivery require the presence of insulin.
0 Communities
2 Members
0 Resources
20 MeSH Terms
Monochromatism determined at a long-wavelength/middle-wavelength cone-antagonistic locus.
Calkins DJ, Thornton JE, Pugh EN
(1992) Vision Res 32: 2349-67
MeSH Terms: Adaptation, Ocular, Color Perception, Discrimination, Psychological, Humans, Male, Mathematics, Models, Neurological, Photoreceptor Cells, Sensory Thresholds, Spectrophotometry, Time Factors
Show Abstract · Added February 12, 2015
The foveal increment threshold spectral sensitivity function for a 500 msec raised cosine stimulus without spatial edges exhibits a sharp drop or "notch" in sensitivity that coincides with the wavelength of a long-wavelength adapting field. An appropriate name for this phenomenon is the "Sloan notch", after Louise Sloan, who first observed a notch in a foveal threshold spectrum. We have examined suprathreshold discriminability on both sides of the Sloan notch produced by a 6700 td, 578 nm adapting field. In a temporal two-alternative forced-choice paradigm, a suprathreshold 650 nm low-frequency "standard" stimulus was paired with low-frequency "test" stimuli, of wavelength between 600 and 670 nm and varied intensity; the observer's task was to identify the interval containing the standard. Discriminability of the test and standard typically dropped to chance for some particular test intensity, producing "indiscriminability action spectra", up to 0.7 log units above threshold. Truncated spectra (between about 530 and 560 nm) were also obtained from observers on the middle wavelength side of the Sloan notch, for a 550 nm standard. The indiscriminability action spectra of each observer were identical, up to scaling, with the observer's threshold action spectrum. Analysis of the action spectra shows that the indiscriminable stimuli are rendered equivalent at the input to a neural pathway where L- and M-cone signals converge with opposite sign. We also investigated discriminability in the spectral region containing and immediately surrounding the Sloan notch. Suprathreshold stimuli in the spectral region near the notch produce percepts that are always discriminable from 650 and 550 nm standards (and from one another), and thus we conclude that in this spectral region, perception is mediated in part by a pathway distinct from that which signals the standards. The action spectrum of this latter pathway was estimated with a variant of the discrimination procedure, and found similar to V lambda over the spectral region 575-610 nm.
0 Communities
1 Members
0 Resources
11 MeSH Terms
Evaluation of the water environments in deoxygenated sickle cells by longitudinal and transverse water proton relaxation rates.
Thompson BC, Waterman MR, Cottam GL
(1975) Arch Biochem Biophys 166: 193-200
MeSH Terms: Anemia, Sickle Cell, Erythrocytes, Hemoglobin, Sickle, Hemoglobins, Abnormal, Humans, Kinetics, Magnetic Resonance Spectroscopy, Mathematics, Oxyhemoglobins, Temperature, Thermodynamics
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Growth of hygroscopic aerosols in a model of bronchial airways.
Scherer PW, Haselton FR, Hanna LM, Stone DR
(1979) J Appl Physiol Respir Environ Exerc Physiol 47: 544-50
MeSH Terms: Aerosols, Biomechanical Phenomena, Body Temperature, Bronchi, Humans, Humidity, Mathematics, Models, Biological, Particle Size
Show Abstract · Added May 27, 2014
Experiments have been performed on the "breathing" of micron-size hygroscopic aerosols in and out of a four-generation model of the bronchial tree. Comparison of the experimental results on aerosol growth in the model with the classical theory for dilute aqueous solutions of nonpolar salts shows a) that the theory is applicable to conditions in the airways, b) that to a high degree of approximation the process represents deposition followed by growth, and c) that there is a significant amount of trapping of particles near their equilibrium size in the deeper model tubes. These experiments are the first to verify that the classical particle growth theory is applicable to the particle sizes and environmental conditions present in the human airways during hygroscopic aerosol therapy. This theory will be useful in designing an optimal hygroscopic aerosol delivery system, but several questions including the method of generation and the effect of drug solutions on particle equilibriums remain to be answered.
0 Communities
1 Members
0 Resources
9 MeSH Terms
Effect of oxygen concentration on trasverse water proton relaxation times in erythrocytes homozygous and heterozygous for hemoglonin S.
Cottam GL, Waterman MR
(1976) Arch Biochem Biophys 177: 293-8
MeSH Terms: Electron Spin Resonance Spectroscopy, Hemoglobin, Sickle, Hemoglobins, Heterozygote, Homozygote, Humans, Hydrogen Bonding, Kinetics, Mathematics, Oxygen, Oxyhemoglobins, Protein Binding, Protein Conformation, Water
Added February 12, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms