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Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods.
Caruso G, Gurevich VV, Klaus C, Hamm H, Makino CL, DiBenedetto E
(2019) PLoS One 14: e0225948
MeSH Terms: Algorithms, Animals, Biomarkers, Calcium, Cyclic GMP, Mice, Models, Biological, Photons, Retinal Rod Photoreceptor Cells, Rod Cell Outer Segment, Signal Transduction
Added March 18, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex.
Khuansuwan S, Clanton JA, Dean BJ, Patton JG, Gamse JT
(2016) Development 143: 2641-50
MeSH Terms: Animals, Body Patterning, Cell Count, Cell Lineage, Cell Movement, Gene Dosage, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Habenula, Larva, Mosaicism, Mutation, Neurons, Pineal Gland, Retinal Rod Photoreceptor Cells, Transcription Factors, Zebrafish, Zebrafish Proteins
Added August 4, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor.
Azevedo AW, Doan T, Moaven H, Sokal I, Baameur F, Vishnivetskiy SA, Homan KT, Tesmer JJ, Gurevich VV, Chen J, Rieke F
(2015) Elife 4:
MeSH Terms: Animals, Arrestin, Binding Sites, Mice, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Receptors, G-Protein-Coupled, Retinal Rod Photoreceptor Cells, Rhodopsin, Serine, Threonine
Added February 15, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms
Development of an MRI biomarker sensitive to tetrameric visual arrestin 1 and its reduction via light-evoked translocation in vivo.
Berkowitz BA, Gorgis J, Patel A, Baameur F, Gurevich VV, Craft CM, Kefalov VJ, Roberts R
(2015) FASEB J 29: 554-64
MeSH Terms: Animals, Arrestins, Biomarkers, Body Weight, Colloids, Diabetes Mellitus, Experimental, Diabetic Retinopathy, Ferric Compounds, Immunohistochemistry, Light, Light Signal Transduction, Magnetic Resonance Imaging, Male, Manganese, Mice, Mice, Inbred C57BL, Nanoparticles, Protein Transport, Retina, Retinal Rod Photoreceptor Cells, Rod Cell Outer Segment, Signal Transduction, beta-Arrestin 1, beta-Arrestins
Added February 12, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Self-association of arrestin family members.
Chen Q, Zhuo Y, Kim M, Hanson SM, Francis DJ, Vishnivetskiy SA, Altenbach C, Klug CS, Hubbell WL, Gurevich VV
(2014) Handb Exp Pharmacol 219: 205-23
MeSH Terms: Animals, Arrestins, Crystallization, Humans, Phytic Acid, Protein Multimerization, Retinal Cone Photoreceptor Cells, Retinal Rod Photoreceptor Cells
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Targeting individual GPCRs with redesigned nonvisual arrestins.
Gimenez LE, Vishnivetskiy SA, Gurevich VV
(2014) Handb Exp Pharmacol 219: 153-70
MeSH Terms: Animals, Arrestins, Humans, Mutation, Phosphates, Phosphorylation, Receptors, G-Protein-Coupled, Retinal Rod Photoreceptor Cells, Rhodopsin, Signal Transduction
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Enhanced phosphorylation-independent arrestins and gene therapy.
Gurevich VV, Song X, Vishnivetskiy SA, Gurevich EV
(2014) Handb Exp Pharmacol 219: 133-52
MeSH Terms: Animals, Arrestins, Feasibility Studies, Genetic Therapy, Humans, Mutation, Phosphorylation, Receptors, G-Protein-Coupled, Retinal Rod Photoreceptor Cells, Rhodopsin
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development.
Wu SY, de Borsetti NH, Bain EJ, Bulow CR, Gamse JT
(2014) Dev Biol 385: 13-22
MeSH Terms: Animals, Cell Differentiation, Epithalamus, Fibroblast Growth Factors, Gene Expression Regulation, Developmental, Habenula, Mediator Complex, Neural Stem Cells, Pineal Gland, Retinal Cone Photoreceptor Cells, Retinal Rod Photoreceptor Cells, Signal Transduction, T-Box Domain Proteins, Transcription, Genetic, Transcriptional Activation, Zebrafish, Zebrafish Proteins
Added July 21, 2014
1 Communities
0 Members
0 Resources
17 MeSH Terms
Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.
Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Altenbach C, Hong Y, Hanson SM, Palazzo MC, Chen J, Hubbell WL, Gurevich EV, Gurevich VV
(2013) Cell Signal 25: 2613-24
MeSH Terms: Animals, Arrestin, Cell Death, MAP Kinase Kinase 4, Mice, Mutation, Protein Multimerization, Retinal Rod Photoreceptor Cells, Rhodopsin
Added December 10, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms
Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina.
Gordon PJ, Yun S, Clark AM, Monuki ES, Murtaugh LC, Levine EM
(2013) J Neurosci 33: 12197-207
MeSH Terms: Animals, Cell Differentiation, Female, Gene Expression Regulation, Developmental, Gene Knock-In Techniques, LIM-Homeodomain Proteins, Male, Mice, Mice, Mutant Strains, Neural Stem Cells, Neurogenesis, Pregnancy, Retina, Retinal Ganglion Cells, Retinal Rod Photoreceptor Cells, Transcription Factors
Added November 2, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms