Use of a neutralizing antibody helps identify structural features critical for binding of toxin TcdA to the host cell surface.
Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB
(2017) J Biol Chem 292
: 14401-14412MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Binding Sites, Antibody, Caco-2 Cells, Clostridioides difficile, Conserved Sequence, Crystallography, X-Ray, Enterocytes, Enterotoxins, Epitope Mapping, Glucosyltransferases, Humans, Immunoglobulin Fab Fragments, Models, Molecular, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Recombinant Proteins, Repetitive Sequences, Amino AcidAdded March 15, 2018
23 MeSH Terms
Breaking the code of DNA binding specificity of TAL-type III effectors.
Boch J, Scholze H, Schornack S, Landgraf A, Hahn S, Kay S, Lahaye T, Nickstadt A, Bonas U
(2009) Science 326
: 1509-12MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Arabidopsis, Bacterial Proteins, Base Pairing, Base Sequence, Biotechnology, Capsicum, DNA, Plant, DNA-Binding Proteins, Genes, Plant, Models, Biological, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Repetitive Sequences, Amino Acid, Tobacco, Transcription Factors, Transcriptional Activation, XanthomonasAdded June 6, 2012
20 MeSH Terms
Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport.
Terry LJ, Wente SR
(2009) Eukaryot Cell 8
: 1814-27MeSH Terms: Active Transport, Cell Nucleus, Animals, Cell Nucleus, Conserved Sequence, Evolution, Molecular, Humans, Nuclear Pore Complex Proteins, Repetitive Sequences, Amino AcidAdded March 21, 2014
8 MeSH Terms
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.
Choe KP, Przybysz AJ, Strange K
(2009) Mol Cell Biol 29
: 2704-15MeSH Terms: Amino Acid Sequence, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Nucleus, Cullin Proteins, DNA-Binding Proteins, Forkhead Transcription Factors, Gene Expression Regulation, Glutathione Transferase, Humans, Isoenzymes, MAP Kinase Kinase 4, Molecular Sequence Data, Phylogeny, Proteasome Endopeptidase Complex, Receptor, Insulin, Recombinant Fusion Proteins, Repetitive Sequences, Amino Acid, Repressor Proteins, Sequence Alignment, Signal Transduction, Stress, Physiological, Transcription Factors, Two-Hybrid System TechniquesAdded December 5, 2013
25 MeSH Terms
Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region.
Miller SA, Tollefson S, Crowe JE, Williams JV, Wright DW
(2007) J Virol 81
: 141-9MeSH Terms: Amino Acid Sequence, Antiviral Agents, Metapneumovirus, Models, Molecular, Molecular Sequence Data, Peptides, Protein Structure, Tertiary, Repetitive Sequences, Amino Acid, Sequence Alignment, Sequence Analysis, Protein, Viral Core Proteins, Viral Fusion ProteinsAdded August 6, 2012
12 MeSH Terms
Dissection of Swa2p/auxilin domain requirements for cochaperoning Hsp70 clathrin-uncoating activity in vivo.
Xiao J, Kim LS, Graham TR
(2006) Mol Biol Cell 17
: 3281-90MeSH Terms: Amino Acid Motifs, Auxilins, Carrier Proteins, Clathrin, HSP70 Heat-Shock Proteins, Molecular Chaperones, Phosphoproteins, Protein Structure, Tertiary, Repetitive Sequences, Amino Acid, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Deletion, Vesicular Transport ProteinsAdded April 6, 2017
13 MeSH Terms
NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.
Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ
(2004) J Med Chem 47
: 4851-7MeSH Terms: Binding Sites, Combinatorial Chemistry Techniques, DNA Helicases, DNA, Single-Stranded, DNA-Binding Proteins, Drug Design, Genes, myc, Humans, Inhibitory Concentration 50, Ligands, Magnetic Resonance Spectroscopy, Models, Molecular, Promoter Regions, Genetic, Protein Conformation, Protein Structure, Tertiary, Proto-Oncogene Mas, RNA-Binding Proteins, Repetitive Sequences, Amino Acid, Structure-Activity RelationshipAdded March 5, 2014
19 MeSH Terms
Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins.
Chen S, Spiegelberg BD, Lin F, Dell EJ, Hamm HE
(2004) J Mol Cell Cardiol 37
: 399-406MeSH Terms: Amino Acid Sequence, Animals, GTP-Binding Protein alpha Subunits, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Heart, Humans, Microfilament Proteins, Molecular Sequence Data, Protein Conformation, Receptors for Activated C Kinase, Receptors, Cell Surface, Repetitive Sequences, Amino Acid, Signal TransductionAdded December 10, 2013
14 MeSH Terms
Minimal nuclear pore complexes define FG repeat domains essential for transport.
Strawn LA, Shen T, Shulga N, Goldfarb DS, Wente SR
(2004) Nat Cell Biol 6
: 197-206MeSH Terms: Active Transport, Cell Nucleus, Cell Membrane Permeability, Cell Survival, Cells, Cultured, Gene Deletion, Karyopherins, Mutation, Nuclear Pore, Nuclear Pore Complex Proteins, Protein Structure, Tertiary, Protein Transport, Repetitive Sequences, Amino Acid, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, beta KaryopherinsAdded March 21, 2014
15 MeSH Terms
Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation.
Ochotorena IL, Hirata D, Kominami K, Potashkin J, Sahin F, Wentz-Hunter K, Gould KL, Sato K, Yoshida Y, Vardy L, Toda T
(2001) J Cell Sci 114
: 2911-20MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Conserved Sequence, DEAD-box RNA Helicases, Fungal Proteins, Genome, Fungal, Humans, Microtubules, Molecular Sequence Data, Mutation, Nuclear Proteins, Phenotype, Protein Binding, RNA Splicing, RNA Stability, RNA, Fungal, RNA, Messenger, Repetitive Sequences, Amino Acid, Ribonucleoproteins, Saccharomyces cerevisiae Proteins, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Splicing Factor U2AF, Transcription, Genetic, Tubulin, Two-Hybrid System TechniquesAdded March 5, 2014
27 MeSH Terms