Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance.
Kaji I, Roland JT, Rathan-Kumar S, Engevik AC, Burman A, Goldstein AE, Watanabe M, Goldenring JR
(2021) JCI Insight 6
: MeSH Terms: Animals, Cell Differentiation, Cells, Cultured, Dibenzazepines, Disease Models, Animal, Enterocytes, Humans, Intestinal Mucosa, Jejunum, Lysophospholipids, Malabsorption Syndromes, Mice, Mice, Knockout, Microvilli, Mucolipidoses, Myosin Type V, Organoids, Primary Cell Culture, Receptors, Notch, Stem Cells, Wnt Signaling PathwayAdded August 16, 2021
21 MeSH Terms
RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
(2021) J Neurochem 158
: 182-196MeSH Terms: Adenosine Deaminase, Animals, CRISPR-Cas Systems, Calcium-Binding Proteins, Electrophysiological Phenomena, Glutamic Acid, High-Throughput Nucleotide Sequencing, Hippocampus, Mice, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Primary Cell Culture, RNA Editing, Synaptic Transmission, gamma-Aminobutyric AcidAdded April 30, 2021
16 MeSH Terms
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC
(2021) J Immunol 206
: 1127-1139MeSH Terms: Adult, Alternaria, Animals, Asthma, Biomarkers, Blood Glucose, Bronchoalveolar Lavage Fluid, Case-Control Studies, Cells, Cultured, Dexamethasone, Disease Models, Animal, Drug Synergism, Female, Glucose Transporter Type 1, Glutaminase, Glutamine, Healthy Volunteers, Humans, Immunosuppressive Agents, Lung, Male, Mice, Middle Aged, Primary Cell Culture, Pyroglyphidae, Th17 Cells, Th2 Cells, Young AdultAdded March 26, 2021
28 MeSH Terms
Lactate activation of α-cell K channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca entry.
Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA
(2020) Mol Metab 42
: 101056MeSH Terms: Animals, Calcium, Cell Line, Cell Membrane, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Islets of Langerhans, KATP Channels, Lactic Acid, Male, Membrane Potentials, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pancreas, Primary Cell Culture, Pyruvic AcidAdded June 14, 2021
19 MeSH Terms
Increased Expression of PD-1 and PD-L1 in Patients With Laryngotracheal Stenosis.
Davis RJ, Lina I, Ding D, Engle EL, Taube J, Gelbard A, Hillel AT
(2021) Laryngoscope 131
: 967-974MeSH Terms: B7-H1 Antigen, Biopsy, Case-Control Studies, Cells, Cultured, Cricoid Cartilage, Female, Fibroblasts, Fibrosis, Humans, Immunohistochemistry, Laryngostenosis, Male, Middle Aged, Primary Cell Culture, Programmed Cell Death 1 Receptor, Trachea, Tracheal Stenosis, TracheostomyAdded July 30, 2020
18 MeSH Terms
infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.
Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D
(2020) Proc Natl Acad Sci U S A 117
: 8064-8073MeSH Terms: Animals, Bacterial Proteins, Bacterial Toxins, Cells, Cultured, Clostridioides difficile, Clostridium Infections, Colon, Disease Models, Animal, Female, Frizzled Receptors, Humans, Intestinal Mucosa, Mice, Organoids, Primary Cell Culture, Recombinant Proteins, Stem CellsAdded March 24, 2020
17 MeSH Terms
Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.
Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ
(2020) Gastroenterology 158
: 1500-1502MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Azoxymethane, Carcinogens, Cells, Cultured, Colonic Neoplasms, Dextran Sulfate, Disease Models, Animal, ErbB Receptors, Gastritis, Hypertrophic, Genes, Reporter, Hepatocytes, Humans, Mice, Mice, Transgenic, Primary Cell CultureAdded January 31, 2020
17 MeSH Terms
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T
(2019) JCI Insight 4
: MeSH Terms: Animals, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Colitis, Ulcerative, Colon, Colorectal Neoplasms, Dextran Sulfate, Disease Models, Animal, Female, Humans, Intestinal Mucosa, Kaplan-Meier Estimate, Macrophages, Male, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Transgenic, Morpholines, Osteopontin, Primary Cell Culture, Prognosis, Survival RateAdded November 6, 2019
24 MeSH Terms
Targeted mobilization of Lrig1 gastric epithelial stem cell populations by a carcinogenic type IV secretion system.
Wroblewski LE, Choi E, Petersen C, Delgado AG, Piazuelo MB, Romero-Gallo J, Lantz TL, Zavros Y, Coffey RJ, Goldenring JR, Zemper AE, Peek RM
(2019) Proc Natl Acad Sci U S A 116
: 19652-19658MeSH Terms: Adenocarcinoma, Animals, Carcinogenesis, Disease Models, Animal, Epithelial Cells, Female, Gastric Mucosa, Gastritis, Helicobacter Infections, Helicobacter pylori, Humans, Male, Membrane Glycoproteins, Mice, Mice, Knockout, Nerve Tissue Proteins, Precancerous Conditions, Primary Cell Culture, Risk Factors, Stem Cells, Stomach, Stomach Neoplasms, Type IV Secretion SystemsAdded September 27, 2019
23 MeSH Terms
Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1.
Vanslambrouck JM, Woodard LE, Suhaimi N, Williams FM, Howden SE, Wilson SB, Lonsdale A, Er PX, Li J, Maksimovic J, Oshlack A, Wilson MH, Little MH
(2019) Kidney Int 95
: 1153-1166MeSH Terms: Cells, Cultured, Cellular Reprogramming, DNA Transposable Elements, Gene Transfer Techniques, Genetic Engineering, Homeodomain Proteins, Humans, Intracellular Signaling Peptides and Proteins, Nephrons, Nuclear Proteins, Primary Cell Culture, Protein Tyrosine Phosphatases, Regeneration, Snail Family Transcription FactorsAdded March 28, 2019
14 MeSH Terms