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TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR Metastatic Triple-Negative Breast Cancer.
Lehmann BD, Abramson VG, Sanders ME, Mayer EL, Haddad TC, Nanda R, Van Poznak C, Storniolo AM, Nangia JR, Gonzalez-Ericsson PI, Sanchez V, Johnson KN, Abramson RG, Chen SC, Shyr Y, Arteaga CL, Wolff AC, Pietenpol JA, Translational Breast Cancer Research Consortium
(2020) Clin Cancer Res 26: 2111-2123
MeSH Terms: Androgen Receptor Antagonists, Antineoplastic Combined Chemotherapy Protocols, Benzamides, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Imidazoles, Middle Aged, Neoplasm Metastasis, Nitriles, Oxazepines, Phenylthiohydantoin, Protein Kinase Inhibitors, Receptors, Androgen, Survival Rate, Triple Negative Breast Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway.
Gobert AP, Latour YL, Asim M, Finley JL, Verriere TG, Barry DP, Milne GL, Luis PB, Schneider C, Rivera ES, Lindsey-Rose K, Schey KL, Delgado AG, Sierra JC, Piazuelo MB, Wilson KT
(2019) mBio 10:
MeSH Terms: Animals, Bacteria, Gene Silencing, Helicobacter pylori, Histones, Humans, Immune Evasion, Immunity, Innate, Immunoglobulins, Macrophages, Male, Metabolic Networks and Pathways, Mice, Mice, Inbred C57BL, Nitric Oxide Synthase Type II, Phosphatidylinositol 3-Kinases, Polyamines, RAW 264.7 Cells, Spermidine, Spermine, Sulfur, Transcription Factors
Added November 1, 2019
0 Communities
2 Members
0 Resources
22 MeSH Terms
Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis.
Linton MF, Moslehi JJ, Babaev VR
(2019) Int J Mol Sci 20:
MeSH Terms: Animals, Apoptosis, Atherosclerosis, Blood Cells, Cell Survival, Humans, Macrophage Activation, Macrophages, Phosphatidylinositol 3-Kinases, Protein Isoforms, Proto-Oncogene Proteins c-akt, Signal Transduction
Added November 12, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
Multiple mechanisms underlie increased cardiac late sodium current.
Kroncke BM, Yang T, Roden DM
(2019) Heart Rhythm 16: 1091-1097
MeSH Terms: Action Potentials, Animals, CHO Cells, Cardiac Conduction System Disease, Cricetinae, Cricetulus, Genotype, Humans, Induced Pluripotent Stem Cells, Kidney, Long QT Syndrome, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Phosphatidylinositol 3-Kinases
Added March 26, 2019
0 Communities
3 Members
0 Resources
15 MeSH Terms
Oncogenic Signaling Pathways in The Cancer Genome Atlas.
Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N
(2018) Cell 173: 321-337.e10
MeSH Terms: Databases, Genetic, Genes, Neoplasm, Humans, Neoplasms, Phosphatidylinositol 3-Kinases, Signal Transduction, Transforming Growth Factor beta, Tumor Suppressor Protein p53, Wnt Proteins
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Hepatic Gi signaling regulates whole-body glucose homeostasis.
Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J
(2018) J Clin Invest 128: 746-759
MeSH Terms: Animals, Blood Glucose, Extracellular Signal-Regulated MAP Kinases, Female, GTP-Binding Protein alpha Subunits, Gi-Go, Gene Expression Profiling, Glucagon, Gluconeogenesis, Glucose, Hepatocytes, Homeostasis, Humans, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxygen, Phosphatidylinositol 3-Kinases, Phosphorylation, Reactive Oxygen Species, Receptors, Glucagon, Signal Transduction
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
(2017) Nat Cell Biol 19: 1313-1325
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cell Polarity, Epithelial Cells, ErbB Receptors, Insulin-Secreting Cells, Mice, Mice, Knockout, Morphogenesis, Nerve Tissue Proteins, Neuropeptides, Organogenesis, Phosphatidylinositol 3-Kinases, Protein Kinase C, Signal Transduction, rac1 GTP-Binding Protein
Added November 7, 2017
1 Communities
1 Members
0 Resources
17 MeSH Terms
ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.
Williams MM, Vaught DB, Joly MM, Hicks DJ, Sanchez V, Owens P, Rahman B, Elion DL, Balko JM, Cook RS
(2017) Breast Cancer Res 19: 105
MeSH Terms: Alleles, Animals, Breast, Cell Differentiation, Cell Proliferation, Cell Survival, Epithelial Cells, Female, Gene Knockout Techniques, Immunohistochemistry, Lactation, Mice, Mice, Transgenic, Phosphatidylinositol 3-Kinases, Pregnancy, Proto-Oncogene Proteins c-akt, RNA, Messenger, Receptor, ErbB-3, Receptor, ErbB-4, STAT5 Transcription Factor, Signal Transduction
Added March 14, 2018
0 Communities
2 Members
0 Resources
21 MeSH Terms
Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs.
Lietman CD, Segedy AK, Li B, Fazio S, Atkinson JB, Linton MF, Young PP
(2017) PLoS One 12: e0184620
MeSH Terms: Animals, Apolipoproteins E, Cornified Envelope Proline-Rich Proteins, Female, Fibronectins, Immunoblotting, Mice, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Real-Time Polymerase Chain Reaction, Signal Transduction
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line.
Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner M, Bowman AB
(2018) Neurotoxicology 64: 185-194
MeSH Terms: Animals, Cell Line, Chromones, Corpus Striatum, HEK293 Cells, Homeostasis, Humans, Induced Pluripotent Stem Cells, Inhibitory Concentration 50, Manganese, Mice, Morpholines, Neural Stem Cells, Phosphatidylinositol 3-Kinase, Signal Transduction, Tumor Suppressor Protein p53
Added April 11, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms