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Cyclooxygenase-2 in adipose tissue macrophages limits adipose tissue dysfunction in obese mice.
Pan Y, Cao S, Tang J, Arroyo JP, Terker AS, Wang Y, Niu A, Fan X, Wang S, Zhang Y, Jiang M, Wasserman DH, Zhang MZ, Harris RC
(2022) J Clin Invest 132:
MeSH Terms: Adipose Tissue, Animals, Cyclooxygenase 2, Dinoprostone, Glucose, Inflammation, Insulin Resistance, Macrophages, Mice, Mice, Inbred C57BL, Mice, Obese, Obesity
Added May 23, 2022
1 Communities
0 Members
0 Resources
MeSH Terms
Hypusination Orchestrates the Antimicrobial Response of Macrophages.
Gobert AP, Finley JL, Latour YL, Asim M, Smith TM, Verriere TG, Barry DP, Allaman MM, Delagado AG, Rose KL, Calcutt MW, Schey KL, Sierra JC, Piazuelo MB, Mirmira RG, Wilson KT
(2020) Cell Rep 33: 108510
MeSH Terms: Animals, Anti-Infective Agents, Disease Models, Animal, Humans, Lysine, Macrophages, Mice
Added December 19, 2020
0 Communities
1 Members
0 Resources
7 MeSH Terms
Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer.
Hoover AA, Hufnagel DH, Harris W, Bullock K, Glass EB, Liu E, Barham W, Crispens MA, Khabele D, Giorgio TD, Wilson AJ, Yull FE
(2020) BMC Cancer 20: 970
MeSH Terms: Animals, Cell Line, Tumor, Disease Models, Animal, Disease Progression, Female, Humans, Macrophages, Mice, Mice, Transgenic, NF-kappa B, Signal Transduction
Added January 29, 2021
1 Communities
0 Members
0 Resources
11 MeSH Terms
Enhanced Expression of Catalase in Mitochondria Modulates NF-κB-Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages.
Han W, Fessel JP, Sherrill T, Kocurek EG, Yull FE, Blackwell TS
(2020) J Immunol 205: 1125-1134
MeSH Terms: Animals, Bone Marrow, Catalase, Lung, Macrophages, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, NAD, NF-kappa B, Pneumonia, Reactive Oxygen Species, Signal Transduction
Added July 28, 2020
1 Communities
0 Members
0 Resources
14 MeSH Terms
Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages.
Rogers LM, Serezani CH, Eastman AJ, Hasty AH, Englund-Ögge L, Jacobsson B, Vickers KC, Aronoff DM
(2020) Placenta 90: 45-51
MeSH Terms: Adult, Apoptosis, Cytokines, Female, Glucose, Humans, Inflammasomes, Insulin, Macrophages, Palmitic Acid, Placenta, Pregnancy
Added March 3, 2020
0 Communities
2 Members
0 Resources
12 MeSH Terms
Regulation of tissue iron homeostasis: the macrophage "ferrostat".
Winn NC, Volk KM, Hasty AH
(2020) JCI Insight 5:
MeSH Terms: Adipose Tissue, Animals, Bone Marrow, Bone and Bones, Central Nervous System, Disease, Erythropoiesis, Health, Homeostasis, Humans, Iron, Liver, Macrophages, Muscle, Skeletal, Myocardium, Pancreas, Skin, Spleen, Wound Healing
Added March 3, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas.
Roussel M, Lhomme F, Roe CE, Bartkowiak T, Gravelle P, Laurent C, Fest T, Irish JM
(2020) Cancer Immunol Immunother 69: 407-420
MeSH Terms: Adult, Aged, Female, Flow Cytometry, Germinal Center, Humans, Lymphoma, Large B-Cell, Diffuse, Macrophages, Male, Middle Aged, Young Adult
Added January 14, 2020
3 Communities
1 Members
0 Resources
11 MeSH Terms
β1 Integrin regulates adult lung alveolar epithelial cell inflammation.
Plosa EJ, Benjamin JT, Sucre JM, Gulleman PM, Gleaves LA, Han W, Kook S, Polosukhin VV, Haake SM, Guttentag SH, Young LR, Pozzi A, Blackwell TS, Zent R
(2020) JCI Insight 5:
MeSH Terms: Aging, Alveolar Epithelial Cells, Animals, Cell Adhesion, Chemokine CCL2, Chemokines, Disease Models, Animal, Epithelium, Integrin beta1, Lung, Macrophages, Mice, Mice, Inbred C57BL, Mice, Knockout, Pneumonia, Pulmonary Disease, Chronic Obstructive, Receptors, CCR2
Added March 3, 2020
0 Communities
3 Members
0 Resources
17 MeSH Terms
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway.
Gobert AP, Latour YL, Asim M, Finley JL, Verriere TG, Barry DP, Milne GL, Luis PB, Schneider C, Rivera ES, Lindsey-Rose K, Schey KL, Delgado AG, Sierra JC, Piazuelo MB, Wilson KT
(2019) mBio 10:
MeSH Terms: Animals, Bacteria, Gene Silencing, Helicobacter pylori, Histones, Humans, Immune Evasion, Immunity, Innate, Immunoglobulins, Macrophages, Male, Metabolic Networks and Pathways, Mice, Mice, Inbred C57BL, Nitric Oxide Synthase Type II, Phosphatidylinositol 3-Kinases, Polyamines, RAW 264.7 Cells, Spermidine, Spermine, Sulfur, Transcription Factors
Added November 1, 2019
0 Communities
2 Members
0 Resources
22 MeSH Terms
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T
(2019) JCI Insight 4:
MeSH Terms: Animals, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Colitis, Ulcerative, Colon, Colorectal Neoplasms, Dextran Sulfate, Disease Models, Animal, Female, Humans, Intestinal Mucosa, Kaplan-Meier Estimate, Macrophages, Male, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Transgenic, Morpholines, Osteopontin, Primary Cell Culture, Prognosis, Survival Rate
Added November 6, 2019
1 Communities
1 Members
0 Resources
24 MeSH Terms