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Results: 1 to 10 of 173

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A randomized pharmacokinetic and pharmacodynamic trial of two regular human insulins demonstrates bioequivalence in type 1 diabetes and availability of biosimilar insulin may improve access to this medication.
Vencio S, Caiado-Vencio R, Caixeta LF, Masierek M, Mlynarski W, Drzewoski J, Gregory JM
(2022) Diabetes Obes Metab 24: 1544-1552
MeSH Terms: Biosimilar Pharmaceuticals, Cross-Over Studies, Diabetes Mellitus, Type 1, Double-Blind Method, Glucose, Glucose Clamp Technique, Humans, Hypoglycemic Agents, Insulin, Insulin, Isophane, Insulin, Regular, Human, Therapeutic Equivalency
Added September 22, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia.
Warner SO, Wadian AM, Smith M, Farmer B, Dai Y, Sheanon N, Edgerton DS, Winnick JJ
(2021) Am J Physiol Endocrinol Metab 320: E914-E924
MeSH Terms: Animals, Blood Glucose, Brain, Dogs, Female, Gluconeogenesis, Glucose, Glucose Clamp Technique, Glycogen, Hypoglycemia, Hypoglycemic Agents, Insulin, Lipid Metabolism, Liver, Liver Glycogen, Male
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
Bachmann KN, Roumie CL, Wiese AD, Grijalva CG, Buse JB, Bradford R, Zalimeni EO, Knoepp P, Dard S, Morris HL, Donahoo WT, Fanous N, Fonseca V, Katalenich B, Choi S, Louzao D, O'Brien E, Cook MM, Rothman RL, Chakkalakal RJ
(2020) Pharmacol Res Perspect 8: e00637
MeSH Terms: Adult, Aged, Comorbidity, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Drug Therapy, Combination, Electronic Health Records, Female, Glucagon-Like Peptide-1 Receptor, Humans, Hyperlipidemias, Hypertension, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Patient-Centered Care, Retrospective Studies, Sodium-Glucose Transporter 2 Inhibitors, Sulfonylurea Compounds, Thiazolidinediones, United States
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Hospitalization for Lactic Acidosis Among Patients With Reduced Kidney Function Treated With Metformin or Sulfonylureas.
Chu PY, Hackstadt AJ, Chipman J, Griffin MR, Hung AM, Greevy RA, Grijalva CG, Elasy T, Roumie CL
(2020) Diabetes Care 43: 1462-1470
MeSH Terms: Acidosis, Lactic, Aged, Cohort Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Glomerular Filtration Rate, Hospitalization, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Renal Insufficiency, Retrospective Studies, Sulfonylurea Compounds, United States, Veterans
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Increased proportion of time in hybrid closed-loop "Auto Mode" is associated with improved glycaemic control for adolescent and young patients with adult type 1 diabetes using the MiniMed 670G insulin pump.
Duffus SH, Ta'ani ZA, Slaughter JC, Niswender KD, Gregory JM
(2020) Diabetes Obes Metab 22: 688-693
MeSH Terms: Adolescent, Blood Glucose, Blood Glucose Self-Monitoring, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Glycemic Control, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Retrospective Studies, Treatment Outcome, Young Adult
Added November 12, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo.
McClatchey PM, Williams IM, Xu Z, Mignemi NA, Hughey CC, McGuinness OP, Beckman JA, Wasserman DH
(2019) Am J Physiol Endocrinol Metab 317: E1022-E1036
MeSH Terms: 4-Chloro-7-nitrobenzofurazan, Animals, Blood Flow Velocity, Carbon Radioisotopes, Deoxyglucose, Dextrans, Glucose, Hypoglycemic Agents, Insulin, Intravital Microscopy, Mice, Microcirculation, Microspheres, Muscle, Skeletal, Ultrasonography
Added March 30, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
Evaluation of weight change and hypoglycaemia as mediators in the association between insulin use and death.
Min JY, Hackstadt AJ, Griffin MR, Greevy RA, Chipman J, Grijalva CG, Hung AM, Roumie CL
(2019) Diabetes Obes Metab 21: 2626-2634
MeSH Terms: Aged, Body Mass Index, Body Weight, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Retrospective Studies, Sulfonylurea Compounds, Veterans
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion.
Barella LF, Rossi M, Zhu L, Cui Y, Mei FC, Cheng X, Chen W, Gurevich VV, Wess J
(2019) J Clin Invest 129: 3732-3737
MeSH Terms: Animals, Genotype, Glyburide, Guanine Nucleotide Exchange Factors, Hypoglycemic Agents, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Mice, Transgenic, Phenotype, Signal Transduction, Sulfonylurea Compounds, Tolbutamide, beta-Arrestin 1, beta-Arrestin 2
Added March 18, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.
Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Madsen P, Kjeldsen TB, Hostrup S, Brand CL, Fledelius C, Nishimura E, Cherrington AD
(2019) Diabetes Obes Metab 21: 2294-2304
MeSH Terms: Animals, Blood Glucose, Diabetes Mellitus, Type 1, Dogs, Gluconeogenesis, Humans, Hypoglycemia, Hypoglycemic Agents, Infusions, Intravenous, Insulin, Insulin, Regular, Human, Liver, Male, Portal Vein
Added June 26, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Preparation, preliminary pharmacokinetic and brain targeting study of metformin encapsulated W/O/W composite submicron emulsions promoted by borneol.
Hong L, Li X, Bao Y, Duvall CL, Zhang C, Chen W, Peng C
(2019) Eur J Pharm Sci 133: 160-166
MeSH Terms: Animals, Brain, Camphanes, Drug Compounding, Drug Delivery Systems, Drug Liberation, Emulsions, Female, Hypoglycemic Agents, Male, Metformin, Rats, Sprague-Dawley
Added April 10, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms