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Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
Turner HL, Pallesen J, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE, Wilson IA, Ward AB
(2019) PLoS Biol 17: e3000139
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, Antibody Specificity, Baculoviridae, Binding Sites, Cloning, Molecular, Cryoelectron Microscopy, Gene Expression, Hemagglutinin Glycoproteins, Influenza Virus, Hydrogen Bonding, Immunoglobulin Fab Fragments, Influenza A virus, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Recombinant Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Sf9 Cells, Spodoptera
Added March 31, 2019
0 Communities
1 Members
0 Resources
23 MeSH Terms
Antibody Determinants of Influenza Immunity.
Crowe JE
(2019) J Infect Dis 219: S21-S29
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigens, Viral, B-Lymphocytes, Cross Reactions, Genetic Drift, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunologic Memory, Influenza A virus, Influenza Vaccines, Influenza, Human, Neuraminidase, Point Mutation, Vaccination, Vaccines, Inactivated
Added March 31, 2019
0 Communities
1 Members
0 Resources
17 MeSH Terms
Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.
Sevy AM, Wu NC, Gilchuk IM, Parrish EH, Burger S, Yousif D, Nagel MBM, Schey KL, Wilson IA, Crowe JE, Meiler J
(2019) Proc Natl Acad Sci U S A 116: 1597-1602
MeSH Terms: Amino Acid Sequence, Antibodies, Neutralizing, Antibodies, Viral, Crystallography, X-Ray, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenza A virus, Influenza, Human, Seasons
Added March 31, 2019
0 Communities
3 Members
0 Resources
MeSH Terms
Structural Insights into Reovirus σ1 Interactions with Two Neutralizing Antibodies.
Dietrich MH, Ogden KM, Katen SP, Reiss K, Sutherland DM, Carnahan RH, Goff M, Cooper T, Dermody TS, Stehle T
(2017) J Virol 91:
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, CHO Cells, Cell Line, Cricetulus, Hemagglutinin Glycoproteins, Influenza Virus, Immunoglobulin Fab Fragments, Mice, Molecular Docking Simulation, Molecular Dynamics Simulation, Neutralization Tests, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Reoviridae, Structure-Activity Relationship, Viral Proteins, Virus Replication
Added April 26, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Winarski KL, Thornburg NJ, Yu Y, Sapparapu G, Crowe JE, Spiller BW
(2015) Proc Natl Acad Sci U S A 112: 9346-51
MeSH Terms: Amino Acid Sequence, Antibodies, Monoclonal, Antibodies, Viral, Binding Sites, Crystallography, X-Ray, Genetic Variation, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunoglobulin Fragments, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Influenza, Human, Molecular Conformation, Molecular Sequence Data, Mutation, N-Acetylneuraminic Acid, Protein Binding, Protein Structure, Tertiary, Sequence Homology, Amino Acid
Added January 26, 2016
0 Communities
2 Members
0 Resources
19 MeSH Terms
Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head.
Krause JC, Crowe JE
(2014) Microbiol Spectr 2:
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cross Reactions, Crystallography, X-Ray, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenzavirus A, Protein Conformation
Added January 26, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
The contrasting phylodynamics of human influenza B viruses.
Vijaykrishna D, Holmes EC, Joseph U, Fourment M, Su YC, Halpin R, Lee RT, Deng YM, Gunalan V, Lin X, Stockwell TB, Fedorova NB, Zhou B, Spirason N, Kühnert D, Bošková V, Stadler T, Costa AM, Dwyer DE, Huang QS, Jennings LC, Rawlinson W, Sullivan SG, Hurt AC, Maurer-Stroh S, Wentworth DE, Smith GJ, Barr IG
(2015) Elife 4: e05055
MeSH Terms: Age Distribution, Animals, Antigens, Viral, Asparagine, Dogs, Evolution, Molecular, Genetic Variation, Genome, Viral, Glycosylation, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenza A virus, Influenza B virus, Influenza, Human, Madin Darby Canine Kidney Cells, Models, Molecular, New Zealand, Phylogeny, Reassortant Viruses, Selection, Genetic, Time Factors, Victoria
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site.
Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Ward AB, Wilson IA
(2013) J Virol 87: 12471-80
MeSH Terms: Antibodies, Viral, Antibody Affinity, Antigens, Viral, Binding Sites, Antibody, Crystallography, X-Ray, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Models, Molecular, Pandemics, Protein Conformation, Receptors, Virus, United States
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Vitamin D is not associated with serologic response to influenza vaccine in adults over 50 years old.
Sundaram ME, Talbot HK, Zhu Y, Griffin MR, Spencer S, Shay DK, Coleman LA
(2013) Vaccine 31: 2057-61
MeSH Terms: Aged, Antibodies, Viral, Body Mass Index, Female, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunity, Cellular, Influenza A Virus, H1N1 Subtype, Influenza Vaccines, Influenza, Human, Male, Middle Aged, Seasons, Vaccination, Vitamin D, Vitamin D Deficiency
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
A new determinant of H5N1 influenza virus pathogenesis in mammals.
Dermody TS, Sandri-Goldin RM, Shenk T
(2013) J Virol 87: 4795-6
MeSH Terms: Animals, Female, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Virus Replication
Added May 20, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms