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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch.
Arreola A, Payne LB, Julian MH, de Cubas AA, Daniels AB, Taylor S, Zhao H, Darden J, Bautch VL, Rathmell WK, Chappell JC
(2018) JCI Insight 3:
MeSH Terms: Animals, Diamines, Disease Models, Animal, Endothelial Cells, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hemangioblastoma, Humans, Male, Mice, Mice, Transgenic, Microvessels, Mutation, Receptors, Notch, Retinal Artery, Thiazoles, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added October 30, 2019
0 Communities
2 Members
0 Resources
19 MeSH Terms
VHL type 2B mutations retain VBC complex form and function.
Hacker KE, Lee CM, Rathmell WK
(2008) PLoS One 3: e3801
MeSH Terms: Basic Helix-Loop-Helix Transcription Factors, Elongin, Genetic Predisposition to Disease, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Mutation, Missense, Protein Binding, Transcription Factors, Ubiquitination, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added October 17, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.
Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH
(2008) Oncogene 27: 5354-8
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Biomarkers, Tumor, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hemangioma, Hepatocytes, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Integrases, Liver Neoplasms, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Neovascularization, Pathologic, Oligonucleotide Array Sequence Analysis, Vascular Endothelial Growth Factor A, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added August 19, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
Renal cell carcinoma.
Rini BI, Rathmell WK, Godley P
(2008) Curr Opin Oncol 20: 300-6
MeSH Terms: Algorithms, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Benzenesulfonates, Bevacizumab, Carcinoma, Renal Cell, Humans, Kidney Neoplasms, Mutation, Niacinamide, Nomograms, Phenylurea Compounds, Prognosis, Pyridines, Sirolimus, Sorafenib, Vascular Endothelial Growth Factor A, von Hippel-Lindau Disease
Added October 17, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
The VHL tumor suppressor and HIF: insights from genetic studies in mice.
Kapitsinou PP, Haase VH
(2008) Cell Death Differ 15: 650-9
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Carcinoma, Renal Cell, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Genotype, Germ-Line Mutation, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Kidney Neoplasms, Mice, Mice, Knockout, Neoplasms, Phenotype, Ubiquitin-Protein Ligases, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added February 27, 2014
0 Communities
2 Members
0 Resources
17 MeSH Terms
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH
(2007) J Clin Invest 117: 1068-77
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Disease Models, Animal, Erythropoietin, Gene Expression Regulation, Hepatocytes, Liver, Mice, Mice, Knockout, Polycythemia Vera, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added August 19, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms
The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease.
Haase VH
(2006) Kidney Int 69: 1302-7
MeSH Terms: Acute Kidney Injury, Carcinoma, Renal Cell, Chronic Disease, Humans, Hypoxia-Inducible Factor 1, Kidney Diseases, Kidney Neoplasms, Models, Biological, Oxygen, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added August 19, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor.
Rankin EB, Tomaszewski JE, Haase VH
(2006) Cancer Res 66: 2576-83
MeSH Terms: Animals, Aryl Hydrocarbon Receptor Nuclear Translocator, Gene Silencing, Hypoxia-Inducible Factor 1, alpha Subunit, Kidney Diseases, Cystic, Kidney Tubules, Proximal, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Nephrons, Phosphoenolpyruvate Carboxylase, Promoter Regions, Genetic, Rats, Recombinases, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added September 9, 2013
0 Communities
1 Members
1 Resources
18 MeSH Terms
VHL: oxygen sensing and vasculogenesis.
Rathmell WK, Simon MC
(2005) J Thromb Haemost 3: 2627-32
MeSH Terms: Aryl Hydrocarbon Receptor Nuclear Translocator, Blood Vessels, Hematopoiesis, Humans, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, Oxygen, von Hippel-Lindau Disease
Added October 17, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.
Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH
(2005) Mol Cell Biol 25: 3163-72
MeSH Terms: Animals, Aryl Hydrocarbon Receptor Nuclear Translocator, DNA-Binding Proteins, Erythropoietin, Gene Deletion, Gene Expression, Gene Silencing, Genes, Tumor Suppressor, Hemangioma, Cavernous, Hepatocytes, Hypoxia-Inducible Factor 1, alpha Subunit, Liver, Liver Neoplasms, Mice, Mice, Knockout, Phosphotransferases (Alcohol Group Acceptor), Polycythemia, Receptors, Aryl Hydrocarbon, Transcription Factors, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Vascular Endothelial Growth Factor A, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added August 19, 2013
0 Communities
1 Members
0 Resources
24 MeSH Terms