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MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors.
Brown RE, Jacobse J, Anant SA, Blunt KM, Chen B, Vega PN, Jones CT, Pilat JM, Revetta F, Gorby AH, Stengel KR, Choksi YA, Palin K, Piazuelo MB, Washington MK, Lau KS, Goettel JA, Hiebert SW, Short SP, Williams CS
(2022) JCI Insight 7:
MeSH Terms: Animals, Carcinogenesis, Cell Transformation, Neoplastic, Colitis, Dextran Sulfate, Humans, Inflammatory Bowel Diseases, Mice, Mice, Inbred C57BL, Mice, Knockout, Transcription Factors
Added June 13, 2022
1 Communities
0 Members
0 Resources
MeSH Terms
A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response.
Held JP, Feng G, Saunders BR, Pereira CV, Burkewitz K, Patel MR
(2022) Elife 11:
MeSH Terms: Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Mitochondria, Transcription Factors, Unfolded Protein Response
Added June 6, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A
(2022) JCI Insight 7:
MeSH Terms: Acute Kidney Injury, Animals, Cell Line, Cells, Cultured, Discoidin Domain Receptor 1, Female, Fibrosis, Gene Expression Regulation, Inflammation, Kidney Tubules, Proximal, Male, Mice, Mice, Knockout, Phosphorylation, Proto-Oncogene Proteins c-bcr, RNA, STAT3 Transcription Factor, Signal Transduction
Added December 27, 2021
0 Communities
1 Members
0 Resources
18 MeSH Terms
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
(2021) Cell Rep 37: 109813
MeSH Terms: Animals, Animals, Genetically Modified, Blood Glucose, Calcium Signaling, Cell Line, Cellular Senescence, DNA Damage, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Insulin, Insulin-Secreting Cells, Maf Transcription Factors, Large, Male, Mice, Inbred C57BL, Mutation, Missense, Phenotype, Sex Characteristics, Sex Factors
Added November 23, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.
Dudek KD, Osipovich AB, Cartailler JP, Gu G, Magnuson MA
(2021) G3 (Bethesda) 11:
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Endocrine Cells, Eye Proteins, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, PAX6 Transcription Factor, RNA, RNA Splicing, Repressor Proteins, Transcription Factors
Added September 24, 2021
2 Communities
2 Members
0 Resources
13 MeSH Terms
Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation.
Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR
(2021) Target Oncol 16: 663-674
MeSH Terms: Cell Differentiation, Humans, Janus Kinase 1, Leukemia, Leukemia, Myeloid, Acute, Proteomics, STAT5 Transcription Factor, Tretinoin
Added August 31, 2021
3 Communities
1 Members
0 Resources
8 MeSH Terms
Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.
Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH
(2021) Kidney Int 99: 657-670
MeSH Terms: Animals, DNA-Binding Proteins, High Mobility Group Proteins, Humans, Kidney, Mice, Mitochondrial Proteins, Transcription Factors
Added November 10, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS
(2020) Gastroenterology 159: 2101-2115.e5
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Chemoreceptor Cells, Crohn Disease, DNA, Bacterial, Disease Models, Animal, Feces, Female, Gastrointestinal Microbiome, Humans, Ileitis, Ileum, Intestinal Mucosa, Male, Mice, Mice, Knockout, Protective Factors, RNA, Ribosomal, 16S, RNA-Seq, Single-Cell Analysis, Succinic Acid
Added September 17, 2020
0 Communities
1 Members
0 Resources
21 MeSH Terms
Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D.
DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM
(2020) Gastroenterology 159: 1866-1881.e8
MeSH Terms: Animals, Carcinoma, Pancreatic Ductal, Cell Transformation, Neoplastic, Ceruletide, Disease Models, Animal, Energy Metabolism, Fibrosis, Humans, Interleukins, Intramolecular Oxidoreductases, Mice, Transgenic, Mutation, Octamer Transcription Factors, Pancreas, Pancreatic Neoplasms, Pancreatitis, Prostaglandin D2, Proto-Oncogene Proteins p21(ras), Time Factors, Transcription Factors
Added March 13, 2021
0 Communities
1 Members
0 Resources
20 MeSH Terms
Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.
Paliouras AR, Buzzetti M, Shi L, Donaldson IJ, Magee P, Sahoo S, Leong HS, Fassan M, Carter M, Di Leva G, Krebs MG, Blackhall F, Lovly CM, Garofalo M
(2020) EMBO Mol Med 12: e11099
MeSH Terms: Animals, Carcinoma, Non-Small-Cell Lung, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Mice, Oncogene Proteins, Fusion, Protein Kinase Inhibitors, Transcription, Genetic
Added September 10, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms