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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 80

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Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
Dosch AR, Dai X, Reyzer ML, Mehra S, Srinivasan S, Willobee BA, Kwon D, Kashikar N, Caprioli R, Merchant NB, Nagathihalli NS
(2020) Mol Cancer Res 18: 623-631
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Dasatinib, Deoxycytidine, Disease Models, Animal, ErbB Receptors, Erlotinib Hydrochloride, Female, Humans, Mice, Mice, Nude, Pancreatic Neoplasms, Protein Kinase Inhibitors, STAT3 Transcription Factor, Signal Transduction, Stromal Cells, Survival Analysis, Xenograft Model Antitumor Assays, src-Family Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
20 MeSH Terms
Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase.
Berndt S, Gurevich VV, Iverson TM
(2019) PLoS One 14: e0215140
MeSH Terms: Crystallography, X-Ray, Humans, Mutation, Neoplasms, Protein Structure, Tertiary, Recombinant Proteins, src Homology Domains, src-Family Kinases
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Matrix stiffness regulates vascular integrity through focal adhesion kinase activity.
Wang W, Lollis EM, Bordeleau F, Reinhart-King CA
(2019) FASEB J 33: 1199-1208
MeSH Terms: Adherens Junctions, Animals, Antigens, CD, Cadherins, Capillary Permeability, Chick Embryo, Endothelium, Vascular, Enzyme Activation, Extracellular Matrix, Female, Focal Adhesion Protein-Tyrosine Kinases, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Transgenic, Phosphorylation, Protein Transport, Tyrosine, src-Family Kinases
Added April 10, 2019
0 Communities
1 Members
0 Resources
19 MeSH Terms
SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer.
Ichihara E, Westover D, Meador CB, Yan Y, Bauer JA, Lu P, Ye F, Kulick A, de Stanchina E, McEwen R, Ladanyi M, Cross D, Pao W, Lovly CM
(2017) Cancer Res 77: 2990-3000
MeSH Terms: Acrylamides, Aniline Compounds, Animals, Antineoplastic Agents, Drug Resistance, Neoplasm, ErbB Receptors, Female, Focal Adhesion Protein-Tyrosine Kinases, Humans, Lung Neoplasms, Mice, Mice, Nude, Mutation, Piperazines, Signal Transduction, Transfection, src-Family Kinases
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, Wälchli S, Green MR, Trøen G, Liestøl K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R
(2017) Blood 129: 759-770
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, CD79 Antigens, Diagnosis, Differential, Flow Cytometry, Gene Expression Regulation, Neoplastic, Humans, Immunoglobulin M, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Phospholipase C gamma, Phosphoproteins, Phosphorylation, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-akt, Receptors, Antigen, B-Cell, STAT1 Transcription Factor, STAT5 Transcription Factor, Signal Transduction, Single-Cell Analysis, Syk Kinase, p38 Mitogen-Activated Protein Kinases, src-Family Kinases
Added December 31, 2016
1 Communities
1 Members
0 Resources
26 MeSH Terms
Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis.
Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Morales-Tirado , Yates CR
(2017) Mol Pharmacol 91: 1-13
MeSH Terms: Animals, Benzoxazines, Cell Movement, Cell Proliferation, Disease Models, Animal, Endothelial Cells, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mice, Inbred C57BL, Models, Biological, Oxygen, Paxillin, Retinal Neovascularization, Signal Transduction, Small Molecule Libraries, Vascular Endothelial Growth Factor A, src-Family Kinases
Added June 11, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Laminin-111 peptide C16 regulates invadopodia activity of malignant cells through β1 integrin, Src and ERK 1/2.
Siqueira AS, Pinto MP, Cruz MC, Smuczek B, Cruz KS, Barbuto JA, Hoshino D, Weaver AM, Freitas VM, Jaeger RG
(2016) Oncotarget 7: 47904-47917
MeSH Terms: Carcinoma, Squamous Cell, Cell Line, Tumor, Fibrosarcoma, Head and Neck Neoplasms, Humans, Integrin beta1, Laminin, MAP Kinase Signaling System, Mouth Neoplasms, Peptide Fragments, Podosomes, Squamous Cell Carcinoma of Head and Neck, Transfection, src-Family Kinases
Added April 26, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.
West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD
(2016) PLoS One 11: e0148657
MeSH Terms: Animals, Bone Morphogenetic Protein Receptors, Type II, Cell Movement, Cytoskeletal Proteins, Gene Expression Profiling, Gene Expression Regulation, Hypertension, Pulmonary, Indoles, Lung, Mice, Mice, Transgenic, Muscle Contraction, Muscle Proteins, Mutation, Myocytes, Smooth Muscle, Oligonucleotide Array Sequence Analysis, Phosphorylation, Protein Transport, Receptor, Serotonin, 5-HT2B, Serotonin Antagonists, Signal Transduction, Urea, Vascular Stiffness, src-Family Kinases
Added April 11, 2017
0 Communities
2 Members
0 Resources
24 MeSH Terms
Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis.
Tao H, Yancey PG, Babaev VR, Blakemore JL, Zhang Y, Ding L, Fazio S, Linton MF
(2015) J Lipid Res 56: 1449-60
MeSH Terms: Animals, Apoptosis, Atherosclerosis, CD36 Antigens, Cell Survival, Collagen, Gene Deletion, Hematopoiesis, Macrophages, Mice, Mice, Inbred C57BL, Necrosis, Phagocytosis, Phagosomes, Phosphatidylinositol 3-Kinases, Phosphatidylserines, Protein Transport, Signal Transduction, rac1 GTP-Binding Protein, src-Family Kinases
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Perspective on computational and structural aspects of kinase discovery from IPK2014.
Martin E, Knapp S, Engh RA, Moebitz H, Varin T, Roux B, Meiler J, Berdini V, Baumann A, Vieth M
(2015) Biochim Biophys Acta 1854: 1595-604
MeSH Terms: Amino Acid Sequence, Binding Sites, CSK Tyrosine-Protein Kinase, Computational Biology, Humans, Protein Binding, Protein Conformation, Protein Kinase Inhibitors, Protein Kinases, Proto-Oncogene Proteins c-abl, src-Family Kinases
Added February 5, 2016
1 Communities
2 Members
0 Resources
11 MeSH Terms