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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 47

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Control of antiviral innate immune response by protein geranylgeranylation.
Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D
(2019) Sci Adv 5: eaav7999
MeSH Terms: Adaptor Proteins, Signal Transducing, Alkyl and Aryl Transferases, Animals, Endoplasmic Reticulum, Female, Humans, Immunity, Innate, Macrophages, Alveolar, Male, Mice, Knockout, Neuropeptides, Orthomyxoviridae Infections, Protein Prenylation, Receptor-Interacting Protein Serine-Threonine Kinases, Tripartite Motif Proteins, Ubiquitin-Protein Ligases, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 24, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
A neutralizing antibody that blocks delivery of the enzymatic cargo of toxin TcdB into host cells.
Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB
(2018) J Biol Chem 293: 941-952
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Bacterial Toxins, Caco-2 Cells, Clostridioides difficile, Crystallography, X-Ray, Cytosol, Enterotoxins, Humans, Hydrogen-Ion Concentration, Microscopy, Electron, Rubidium, rac1 GTP-Binding Protein
Added March 15, 2018
0 Communities
2 Members
0 Resources
13 MeSH Terms
Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs.
Cleghorn WM, Bulus N, Kook S, Gurevich VV, Zent R, Gurevich EV
(2018) Cell Signal 42: 259-269
MeSH Terms: Actin Cytoskeleton, Animals, Cell Adhesion, Cell Line, Cell Movement, Fibroblasts, Focal Adhesions, Gene Expression Regulation, Mice, Neuropeptides, Receptors, G-Protein-Coupled, Signal Transduction, beta-Arrestin 1, beta-Arrestin 2, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein, rho GTP-Binding Proteins, rhoA GTP-Binding Protein
Added March 14, 2018
0 Communities
1 Members
0 Resources
18 MeSH Terms
EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
(2017) Nat Cell Biol 19: 1313-1325
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cell Polarity, Epithelial Cells, ErbB Receptors, Insulin-Secreting Cells, Mice, Mice, Knockout, Morphogenesis, Nerve Tissue Proteins, Neuropeptides, Organogenesis, Phosphatidylinositol 3-Kinases, Protein Kinase C, Signal Transduction, rac1 GTP-Binding Protein
Added November 7, 2017
1 Communities
1 Members
0 Resources
17 MeSH Terms
Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS
(2017) Breast Cancer Res 19: 74
MeSH Terms: Animals, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Disease Models, Animal, Female, Gene Amplification, Heterografts, Humans, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Transgenic, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, Receptor, ErbB-2, Signal Transduction, rac1 GTP-Binding Protein, rho Guanine Nucleotide Dissociation Inhibitor beta
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.
Morrison MM, Young CD, Wang S, Sobolik T, Sanchez VM, Hicks DJ, Cook RS, Brantley-Sieders DM
(2015) PLoS Genet 11: e1005291
MeSH Terms: Animals, Carrier Proteins, Cell Line, Cell Movement, Cell Survival, Female, Mammary Glands, Animal, Mammary Neoplasms, Animal, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred C57BL, Mice, Transgenic, Morphogenesis, Multiprotein Complexes, Neoplasm Invasiveness, Neuropeptides, Organ Culture Techniques, Phosphorylation, Protein Kinase C-alpha, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, TOR Serine-Threonine Kinases, rac1 GTP-Binding Protein
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis.
Tao H, Yancey PG, Babaev VR, Blakemore JL, Zhang Y, Ding L, Fazio S, Linton MF
(2015) J Lipid Res 56: 1449-60
MeSH Terms: Animals, Apoptosis, Atherosclerosis, CD36 Antigens, Cell Survival, Collagen, Gene Deletion, Hematopoiesis, Macrophages, Mice, Mice, Inbred C57BL, Necrosis, Phagocytosis, Phagosomes, Phosphatidylinositol 3-Kinases, Phosphatidylserines, Protein Transport, Signal Transduction, rac1 GTP-Binding Protein, src-Family Kinases
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of toxemia in patients with Clostridium difficile infection.
Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H
(2015) PLoS One 10: e0124235
MeSH Terms: Animals, Anti-Bacterial Agents, Antibodies, Bacterial, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Biological Assay, Blood Preservation, Chlorocebus aethiops, Clostridioides difficile, Diverticulitis, Colonic, Enterocolitis, Pseudomembranous, Enterotoxins, False Negative Reactions, Female, Glycosylation, Humans, Immunocompromised Host, Immunoglobulin G, Multiple Trauma, Protein Processing, Post-Translational, Protein Stability, Risk Factors, Toxemia, Vero Cells, Young Adult, rac1 GTP-Binding Protein
Added June 2, 2017
0 Communities
1 Members
0 Resources
27 MeSH Terms
Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility.
Allison P, Espiritu D, Barnett JV, Camenisch TD
(2015) Cell Signal 27: 453-9
MeSH Terms: Actin Cytoskeleton, Amino Acid Substitution, Animals, Arrestin, Cell Movement, Cells, Cultured, Epithelial-Mesenchymal Transition, Hyaluronic Acid, Mice, Neuropeptides, Pericardium, Protein Binding, Proteoglycans, RNA Interference, RNA, Small Interfering, Receptors, Transforming Growth Factor beta, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, src-Family Kinases
Added February 21, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC
(2014) Gastroenterology 147: 1405-16.e7
MeSH Terms: Acinar Cells, Adenocarcinoma, Animals, Carcinogenesis, Carcinoma, Pancreatic Ductal, Cell Transformation, Neoplastic, Class I Phosphatidylinositol 3-Kinases, Cytoskeleton, Female, Humans, Male, Mice, Mutant Strains, Neuropeptides, Phosphatidylinositol 3-Kinases, Primary Cell Culture, Proto-Oncogene Proteins p21(ras), Signal Transduction, Transcriptome, rac1 GTP-Binding Protein
Added March 13, 2021
0 Communities
1 Members
0 Resources
MeSH Terms