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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 25

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Control of antiviral innate immune response by protein geranylgeranylation.
Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D
(2019) Sci Adv 5: eaav7999
MeSH Terms: Adaptor Proteins, Signal Transducing, Alkyl and Aryl Transferases, Animals, Endoplasmic Reticulum, Female, Humans, Immunity, Innate, Macrophages, Alveolar, Male, Mice, Knockout, Neuropeptides, Orthomyxoviridae Infections, Protein Prenylation, Receptor-Interacting Protein Serine-Threonine Kinases, Tripartite Motif Proteins, Ubiquitin-Protein Ligases, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 24, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
p47(phox) contributes to albuminuria and kidney fibrosis in mice.
Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A
(2015) Kidney Int 87: 948-62
MeSH Terms: Albuminuria, Animals, Collagen Type IV, Doxorubicin, ErbB Receptors, Integrin alpha1, Kidney, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, NADPH Oxidases, Nephrosclerosis, Oxidative Stress, Reactive Oxygen Species, rac GTP-Binding Proteins
Added January 20, 2015
1 Communities
4 Members
1 Resources
15 MeSH Terms
CD148 tyrosine phosphatase promotes cadherin cell adhesion.
Takahashi K, Matafonov A, Sumarriva K, Ito H, Lauhan C, Zemel D, Tsuboi N, Chen J, Reynolds A, Takahashi T
(2014) PLoS One 9: e112753
MeSH Terms: Cadherins, Cell Adhesion, Cell Line, Drosophila Proteins, Humans, Phosphorylation, Receptor-Like Protein Tyrosine Phosphatases, Class 3, Tyrosine, beta Catenin, cdc42 GTP-Binding Protein, rac GTP-Binding Proteins, rhoA GTP-Binding Protein
Added February 12, 2015
1 Communities
2 Members
0 Resources
12 MeSH Terms
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH, Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW
(2015) Oncogene 34: 3968-76
MeSH Terms: Animals, Breast Neoplasms, Cell Survival, Feedback, Physiological, Female, Guanine Nucleotide Exchange Factors, Humans, MAP Kinase Signaling System, MCF-7 Cells, Mice, Inbred NOD, Mice, SCID, Mutation, Neoplasm Transplantation, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Receptors, Growth Factor, rac GTP-Binding Proteins
Added October 21, 2014
0 Communities
2 Members
0 Resources
17 MeSH Terms
Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen.
Jean L, Majumdar D, Shi M, Hinkle LE, Diggins NL, Ao M, Broussard JA, Evans JC, Choma DP, Webb DJ
(2013) J Cell Sci 126: 5585-97
MeSH Terms: Cell Adhesion, Cell Line, Tumor, Cell Movement, Collagen Type I, Guanine Nucleotide Exchange Factors, Humans, Integrin beta1, Myosin Type II, cdc42 GTP-Binding Protein, rac GTP-Binding Proteins
Added May 20, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y
(2013) Nat Commun 4: 1589
MeSH Terms: Actin Cytoskeleton, Animals, CHO Cells, Cadherins, Catenins, Cell Polarity, Chickens, Cricetinae, Embryo, Mammalian, Fibroblasts, Fluorescent Dyes, Integrins, Intercellular Junctions, Mice, Models, Biological, Phosphatidylinositol 3-Kinases, Protein Binding, RNA, Small Interfering, Rats, Recombinant Fusion Proteins, Signal Transduction, beta Catenin, rac GTP-Binding Proteins
Added March 28, 2014
1 Communities
1 Members
0 Resources
23 MeSH Terms
Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.
Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA
(2013) PLoS One 8: e55325
MeSH Terms: Animals, Blotting, Western, Cytoskeleton, Macrophages, Mice, Neuropeptides, Neutrophil Infiltration, Pancreatitis, Phagocytosis, Phosphatidic Acids, Phospholipase D, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 13, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Synthetic spatially graded Rac activation drives cell polarization and movement.
Lin B, Holmes WR, Wang CJ, Ueno T, Harwell A, Edelstein-Keshet L, Inoue T, Levchenko A
(2012) Proc Natl Acad Sci U S A 109: E3668-77
MeSH Terms: Cell Movement, Cell Polarity, Enzyme Activation, HeLa Cells, Humans, Models, Biological, Phosphatidylinositol 3-Kinases, Protein Multimerization, Sirolimus, Time Factors, rac GTP-Binding Proteins
Added February 26, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms
Modelling cell polarization driven by synthetic spatially graded Rac activation.
Holmes WR, Lin B, Levchenko A, Edelstein-Keshet L
(2012) PLoS Comput Biol 8: e1002366
MeSH Terms: Cell Membrane, Cell Polarity, Cell Shape, Computational Biology, Computer Simulation, Cytosol, Enzyme Activation, Feedback, Physiological, HeLa Cells, Humans, Models, Biological, Phosphatidylinositols, Receptor Cross-Talk, cdc42 GTP-Binding Protein, rac GTP-Binding Proteins, rho GTP-Binding Proteins
Added February 26, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.
Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J
(2012) Am J Physiol Lung Cell Mol Physiol 302: L474-84
MeSH Terms: Amino Acid Substitution, Angiotensin-Converting Enzyme 2, Animals, Blood Pressure, Bone Morphogenetic Protein Receptors, Type II, Cells, Cultured, Cytoskeleton, Endothelial Cells, Enzyme Activation, Familial Primary Pulmonary Hypertension, Female, Gene Expression Profiling, Heart Ventricles, Humans, Hypertension, Pulmonary, Lung, Male, Mice, Mice, Transgenic, Microvessels, Neuropeptides, Oligonucleotide Array Sequence Analysis, Peptidyl-Dipeptidase A, Phosphorylation, Recombinant Proteins, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added April 25, 2013
0 Communities
3 Members
0 Resources
27 MeSH Terms