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Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
Feng Q, Bonder EM, Engevik AC, Zhang L, Tyska MJ, Goldenring JR, Gao N
(2017) J Cell Sci 130: 2491-2505
MeSH Terms: Animals, Enterocytes, Genetic Diseases, Inborn, Intestinal Diseases, Mice, Mice, Knockout, Microvilli, Myosin Type V, rab GTP-Binding Proteins
Added April 10, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease.
Vogel GF, Janecke AR, Krainer IM, Gutleben K, Witting B, Mitton SG, Mansour S, Ballauff A, Roland JT, Engevik AC, Cutz E, Müller T, Goldenring JR, Huber LA, Hess MW
(2017) Traffic 18: 453-464
MeSH Terms: Caco-2 Cells, Cell Membrane, Enterocytes, Humans, Malabsorption Syndromes, Male, Microvilli, Mucolipidoses, Mutation, Myosin Type V, Protein Transport, Qa-SNARE Proteins, Secretory Vesicles, rab GTP-Binding Proteins
Added April 18, 2017
0 Communities
2 Members
0 Resources
14 MeSH Terms
The Par3 polarity protein is an exocyst receptor essential for mammary cell survival.
Ahmed SM, Macara IG
(2017) Nat Commun 8: 14867
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Apoptosis, Cadherins, Cell Adhesion Molecules, Cell Cycle Proteins, Cell Line, Cell Polarity, Cell Survival, Enzyme Activation, Epithelial Cells, Female, Gene Knockdown Techniques, Golgi Apparatus, Humans, Lysine, Mammary Glands, Animal, Models, Biological, PTEN Phosphohydrolase, Phosphatidylinositol Phosphates, Phosphorylation, Protein Domains, Proto-Oncogene Proteins c-akt, Vesicular Transport Proteins, rab GTP-Binding Proteins
Added April 26, 2017
0 Communities
1 Members
0 Resources
25 MeSH Terms
Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition.
Lapierre LA, Manning EH, Mitchell KM, Caldwell CM, Goldenring JR
(2017) Mol Biol Cell 28: 1088-1100
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Cadherins, Carrier Proteins, Cell Polarity, Dogs, Endosomes, Epithelial Cells, Gene Knockout Techniques, HEK293 Cells, Humans, Intercellular Junctions, Madin Darby Canine Kidney Cells, Membrane Proteins, Occludin, Phosphorylation, Protein Binding, Protein Transport, rab GTP-Binding Proteins
Added April 18, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
Cortactin promotes exosome secretion by controlling branched actin dynamics.
Sinha S, Hoshino D, Hong NH, Kirkbride KC, Grega-Larson NE, Seiki M, Tyska MJ, Weaver AM
(2016) J Cell Biol 214: 197-213
MeSH Terms: Actin-Related Protein 2-3 Complex, Actins, Biological Transport, Cell Line, Tumor, Cell Membrane, Cortactin, Exosomes, Humans, Microfilament Proteins, Models, Biological, Molecular Docking Simulation, Multivesicular Bodies, Phenotype, Protein Binding, Pseudopodia, RNA, Small Interfering, Tetraspanin 30, rab GTP-Binding Proteins
Added April 7, 2017
1 Communities
2 Members
0 Resources
18 MeSH Terms
Rab11-FIP1A regulates early trafficking into the recycling endosomes.
Schafer JC, McRae RE, Manning EH, Lapierre LA, Goldenring JR
(2016) Exp Cell Res 340: 259-73
MeSH Terms: Cell Membrane, Endosomes, Green Fluorescent Proteins, HeLa Cells, Humans, Membrane Proteins, Protein Binding, Protein Transport, Transferrin, rab GTP-Binding Proteins
Added February 4, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, Olden M, Hiraki LT, Tayo BO, Fuchsberger C, Dieffenbach AK, Shuldiner AR, Smith AV, Zappa AM, Lupo A, Kollerits B, Ponte B, Stengel B, Krämer BK, Paulweber B, Mitchell BD, Hayward C, Helmer C, Meisinger C, Gieger C, Shaffer CM, Müller C, Langenberg C, Ackermann D, Siscovick D, DCCT/EDIC, Boerwinkle E, Kronenberg F, Ehret GB, Homuth G, Waeber G, Navis G, Gambaro G, Malerba G, Eiriksdottir G, Li G, Wichmann HE, Grallert H, Wallaschofski H, Völzke H, Brenner H, Kramer H, Mateo Leach I, Rudan I, Hillege HL, Beckmann JS, Lambert JC, Luan J, Zhao JH, Chalmers J, Coresh J, Denny JC, Butterbach K, Launer LJ, Ferrucci L, Kedenko L, Haun M, Metzger M, Woodward M, Hoffman MJ, Nauck M, Waldenberger M, Pruijm M, Bochud M, Rheinberger M, Verweij N, Wareham NJ, Endlich N, Soranzo N, Polasek O, van der Harst P, Pramstaller PP, Vollenweider P, Wild PS, Gansevoort RT, Rettig R, Biffar R, Carroll RJ, Katz R, Loos RJ, Hwang SJ, Coassin S, Bergmann S, Rosas SE, Stracke S, Harris TB, Corre T, Zeller T, Illig T, Aspelund T, Tanaka T, Lendeckel U, Völker U, Gudnason V, Chouraki V, Koenig W, Kutalik Z, O'Connell JR, Parsa A, Heid IM, Paterson AD, de Boer IH, Devuyst O, Lazar J, Endlich K, Susztak K, Tremblay J, Hamet P, Jacob HJ, Böger CA, Fox CS, Pattaro C, Köttgen A
(2016) Diabetes 65: 803-17
MeSH Terms: Adult, Aged, Albuminuria, Animals, Cathepsin C, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Gene Knockout Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney, Kidney Tubules, Male, Middle Aged, Polymorphism, Single Nucleotide, Rats, Receptors, Cell Surface, Sulfotransferases, rab GTP-Binding Proteins
Added March 14, 2018
0 Communities
1 Members
0 Resources
22 MeSH Terms
ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization.
Sengupta P, Satpute-Krishnan P, Seo AY, Burnette DT, Patterson GH, Lippincott-Schwartz J
(2015) Proc Natl Acad Sci U S A 112: E6752-61
MeSH Terms: Animals, COS Cells, Chlorocebus aethiops, Endoplasmic Reticulum, Golgi Apparatus, HeLa Cells, Humans, Mitosis, Phospholipases A2, Calcium-Independent, Sirolimus, Tacrolimus Binding Protein 1A, Tacrolimus Binding Proteins, rab GTP-Binding Proteins
Added August 25, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.
Cohen MR, Johnson WM, Pilat JM, Kiselar J, DeFrancesco-Lisowitz A, Zigmond RE, Moiseenkova-Bell VY
(2015) Mol Cell Biol 35: 4238-52
MeSH Terms: Animals, Calcium, Calcium Channels, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, HEK293 Cells, Humans, MAP Kinase Signaling System, Nerve Growth Factor, Neurites, Neurogenesis, Neurons, PC12 Cells, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, RNA Interference, RNA, Small Interfering, Rats, Receptor, trkA, TRPV Cation Channels, rab GTP-Binding Proteins, rab7 GTP-Binding Proteins
Added April 24, 2017
0 Communities
1 Members
0 Resources
22 MeSH Terms
PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.
Hong NH, Qi A, Weaver AM
(2015) J Cell Biol 210: 753-69
MeSH Terms: Actin-Related Protein 2-3 Complex, Actins, Binding Sites, Cell Line, Tumor, Cortactin, Endosomes, Enzyme Activation, HeLa Cells, Humans, Phosphatidylinositol Phosphates, Protein Binding, Protein Structure, Tertiary, RNA Interference, RNA, Small Interfering, Wiskott-Aldrich Syndrome Protein, Neuronal, rab GTP-Binding Proteins, rab7 GTP-Binding Proteins
Added February 15, 2016
1 Communities
1 Members
0 Resources
17 MeSH Terms