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Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability.
Zebda N, Tian Y, Tian X, Gawlak G, Higginbotham K, Reynolds AB, Birukova AA, Birukov KG
(2013) J Biol Chem 288: 18290-9
MeSH Terms: Adherens Junctions, Antigens, CD, Binding Sites, Blotting, Western, Cadherins, Catenins, Cell Membrane, Cell Membrane Permeability, Cells, Cultured, Cytoskeleton, Endothelial Cells, Fluorescent Antibody Technique, GTPase-Activating Proteins, Guanine Nucleotide Exchange Factors, HEK293 Cells, Humans, Mutation, Phosphatidylcholines, Protein Binding, Protein Interaction Mapping, Repressor Proteins, Thrombin, p21-Activated Kinases, rac1 GTP-Binding Protein
Added March 7, 2014
1 Communities
1 Members
0 Resources
24 MeSH Terms
An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons.
Majumdar D, Nebhan CA, Hu L, Anderson B, Webb DJ
(2011) Mol Cell Neurosci 46: 633-44
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Carrier Proteins, Cells, Cultured, Dendritic Spines, Hippocampus, Humans, Nerve Tissue Proteins, Neurons, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RNA, Small Interfering, Rats, Recombinant Fusion Proteins, Signal Transduction, Synapses, p21-Activated Kinases
Added May 20, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21-activated kinase.
Germane KL, Spiller BW
(2011) Biochemistry 50: 917-9
MeSH Terms: Binding Sites, Enteropathogenic Escherichia coli, Escherichia coli Proteins, Models, Molecular, Protein Conformation, Structure-Activity Relationship, Virulence Factors, p21-Activated Kinases
Added May 29, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
p120-catenin is a binding partner and substrate for Group B Pak kinases.
Wong LE, Reynolds AB, Dissanayaka NT, Minden A
(2010) J Cell Biochem 110: 1244-54
MeSH Terms: Animals, Binding, Competitive, Blotting, Western, Catenins, Cell Line, Green Fluorescent Proteins, HeLa Cells, Humans, Immunoprecipitation, Mice, Microscopy, Fluorescence, NIH 3T3 Cells, Phosphorylation, Protein Binding, Serine, Substrate Specificity, Transfection, p21-Activated Kinases
Added March 5, 2014
1 Communities
1 Members
0 Resources
18 MeSH Terms
CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis.
Zayed MA, Yuan W, Leisner TM, Chalothorn D, McFadden AW, Schaller MD, Hartnett ME, Faber JE, Parise LV
(2007) Circ Res 101: 1185-93
MeSH Terms: Angiogenic Proteins, Animals, Calcium-Binding Proteins, Endothelial Cells, Hindlimb, Ischemia, Mice, Mice, Knockout, Neovascularization, Pathologic, Neovascularization, Physiologic, p21-Activated Kinases
Added April 7, 2010
0 Communities
1 Members
0 Resources
11 MeSH Terms
HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta.
Wang SE, Shin I, Wu FY, Friedman DB, Arteaga CL
(2006) Cancer Res 66: 9591-600
MeSH Terms: Actinin, Actins, Adenocarcinoma, Animals, Breast Neoplasms, Cell Line, Tumor, Female, Humans, Mammary Neoplasms, Experimental, Mice, Mice, Transgenic, Neoplasm Metastasis, Neuropeptides, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-vav, Pseudopodia, Receptor, ErbB-2, Recombinant Fusion Proteins, Signal Transduction, Transforming Growth Factor beta1, p21-Activated Kinases, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Cell surface heparan sulfate participates in CXCL1-induced signaling.
Wang D, Sai J, Richmond A
(2003) Biochemistry 42: 1071-7
MeSH Terms: Animals, Binding, Competitive, CHO Cells, Cell Line, Cell Membrane, Cell Migration Inhibition, Chemokine CXCL1, Chemokine CXCL10, Chemokines, Chemokines, CXC, Chemotactic Factors, Chemotaxis, Cricetinae, Heparan Sulfate Proteoglycans, Heparitin Sulfate, Humans, Intercellular Signaling Peptides and Proteins, Protein Binding, Protein Serine-Threonine Kinases, Receptors, Interleukin-8B, Signal Transduction, p21-Activated Kinases
Added May 30, 2013
2 Communities
1 Members
0 Resources
22 MeSH Terms
PAK1 kinase is required for CXCL1-induced chemotaxis.
Wang D, Sai J, Carter G, Sachpatzidis A, Lolis E, Richmond A
(2002) Biochemistry 41: 7100-7
MeSH Terms: Animals, Calcium, Cell Line, Chemokine CXCL1, Chemokines, CXC, Chemotactic Factors, Chemotaxis, Enzyme Activation, Growth Substances, Humans, Intercellular Signaling Peptides and Proteins, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Mitogen-Activated Protein Kinase Kinases, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Rats, Signal Transduction, Tumor Cells, Cultured, cdc42 GTP-Binding Protein, p21-Activated Kinases
Added May 30, 2013
2 Communities
1 Members
0 Resources
21 MeSH Terms
Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.
Westphal RS, Coffee RL, Marotta A, Pelech SL, Wadzinski BE
(1999) J Biol Chem 274: 687-92
MeSH Terms: Amino Acid Sequence, Animals, Glutathione Transferase, Molecular Sequence Data, Phosphoprotein Phosphatases, Precipitin Tests, Protein Binding, Protein Phosphatase 2, Protein Serine-Threonine Kinases, Rats, Recombinant Fusion Proteins, Ribosomal Protein S6 Kinases, Signal Transduction, p21-Activated Kinases
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms