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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 90

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Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice.
Brandt SL, Wang S, Dejani NN, Klopfenstein N, Winfree S, Filgueiras L, McCarthy BP, Territo PR, Serezani CH
(2018) JCI Insight 3:
MeSH Terms: Abscess, Animals, Bacterial Load, Cell Movement, Chemokines, Cytokines, Diabetes Mellitus, Experimental, Female, Inflammation, Leukotriene B4, Macrophages, Male, Methicillin-Resistant Staphylococcus aureus, Mice, Mice, Inbred C57BL, Mice, Knockout, Neutrophils, Receptors, Leukotriene B4, Signal Transduction, Skin, Staphylococcal Skin Infections
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice.
Brandt SL, Klopfenstein N, Wang S, Winfree S, McCarthy BP, Territo PR, Miller L, Serezani CH
(2018) PLoS Pathog 14: e1007244
MeSH Terms: Abscess, Animals, Arachidonate 5-Lipoxygenase, Bacterial Load, Cells, Cultured, Female, Leukotriene B4, Macrophages, Male, Methicillin-Resistant Staphylococcus aureus, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Leukotriene B4, Staphylococcal Skin Infections
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Too much of a good thing: How modulating LTB actions restore host defense in homeostasis or disease.
Brandt SL, Serezani CH
(2017) Semin Immunol 33: 37-43
MeSH Terms: Animals, Cell Movement, Homeostasis, Humans, Immunity, Innate, Immunomodulation, Inflammation, Leukotriene B4, Neutrophils, Phagocytosis
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.
Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH
(2016) Nat Commun 7: 10760
MeSH Terms: Animals, Arachidonate 5-Lipoxygenase, Blotting, Western, Carrier Proteins, Celecoxib, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Cyclooxygenase Inhibitors, Dinoprostone, In Vitro Techniques, Indoles, Indomethacin, Inflammasomes, Interleukin-1beta, Leukotriene B4, Lipoxygenase Inhibitors, Macrophages, Macrophages, Peritoneal, Mice, Mice, Knockout, NF-kappa B, NLR Family, Pyrin Domain-Containing 3 Protein, Phosphoproteins, Prostaglandin Antagonists, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Reverse Transcriptase Polymerase Chain Reaction, Scorpion Stings, Scorpion Venoms, Scorpions, Xanthones
Added May 4, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.
Ribeiro LR, Loures FV, de Araújo EF, Feriotti C, Costa TA, Serezani CH, Jancar S, Calich VL
(2015) Mediators Inflamm 2015: 852574
MeSH Terms: Acetates, Animals, Arachidonate 5-Lipoxygenase, Dinoprostone, Inflammation Mediators, Leukotriene Antagonists, Leukotriene C4, Lipoxins, Macrophages, Alveolar, Male, Mice, Mice, 129 Strain, Mice, Inbred A, Mice, Knockout, Paracoccidioides, Paracoccidioidomycosis, Quinolines, Receptors, Leukotriene, Receptors, Pattern Recognition
Added May 4, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.
Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH
(2015) Sci Signal 8: ra10
MeSH Terms: Analysis of Variance, Animals, Arachidonate 5-Lipoxygenase, Chromatin Immunoprecipitation, Cytokines, Diabetes Mellitus, Type 1, Female, Gene Expression Regulation, Immunoblotting, Inflammation, Inflammation Mediators, Insulin, Leukotriene B4, Macrophages, Mice, Mice, Knockout, Myeloid Differentiation Factor 88, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, STAT1 Transcription Factor, Sepsis
Added May 4, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Use of leukotriene receptor antagonists are associated with a similar risk of asthma exacerbations as inhaled corticosteroids.
Wu AC, Li L, Fung V, Kharbanda EO, Larkin EK, Vollmer WM, Butler MG, Miroshnik I, Rusinak D, Davis RL, Hartert T, Weiss ST, Lieu TA
(2014) J Allergy Clin Immunol Pract 2: 607-13
MeSH Terms: Administration, Inhalation, Adolescent, Adrenal Cortex Hormones, Adrenergic beta-Agonists, Anti-Asthmatic Agents, Asthma, Child, Child, Preschool, Emergency Service, Hospital, Female, Hospitalization, Humans, Leukotriene Antagonists, Male, Retrospective Studies, Rhinitis, Allergic, Risk, Treatment Outcome, United States
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages.
Morato CI, da Silva IA, Borges AF, Dorta ML, Oliveira MA, Jancar S, Serezani CH, Ribeiro-Dias F
(2014) Microbes Infect 16: 945-53
MeSH Terms: Cell Survival, Cells, Cultured, Host-Pathogen Interactions, Humans, Leishmania braziliensis, Leukotriene B4, Macrophages, Reactive Oxygen Species, Receptors, Leukotriene B4
Added May 4, 2017
0 Communities
1 Members
0 Resources
9 MeSH Terms
Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation.
Wang Z, Filgueiras LR, Wang S, Serezani AP, Peters-Golden M, Jancar S, Serezani CH
(2014) J Immunol 192: 2349-56
MeSH Terms: Animals, Female, GTP-Binding Protein alpha Subunits, Gene Expression Regulation, Inflammation, Leukotriene B4, Macrophage Activation, Macrophages, Peritoneal, Mice, Mice, Knockout, MicroRNAs, Myeloid Differentiation Factor 88, Receptors, Leukotriene B4, Signal Transduction, Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling Proteins
Added May 4, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.
Secatto A, Soares EM, Locachevic GA, Assis PA, Paula-Silva FW, Serezani CH, de Medeiros AI, Faccioli LH
(2014) PLoS One 9: e85083
MeSH Terms: Animals, Arachidonate 5-Lipoxygenase, Disease Susceptibility, Enzyme Inhibitors, Gene Expression, Histoplasma, Histoplasmosis, Host Specificity, Host-Pathogen Interactions, Leukotriene B4, Lung, Macrophages, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Phagocytosis, Receptors, Leukotriene B4, Rodent Diseases, Signal Transduction, Spleen
Added May 4, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms