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Results: 1 to 10 of 14

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Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth.
Chukwuma VU, Kose N, Sather DN, Sapparapu G, Falk R, King H, Singh V, Lampley R, Malherbe DC, Ditto NT, Sullivan JT, Barnes T, Doranz BJ, Labranche CC, Montefiori DC, Kalams SA, Haigwood NL, Crowe JE
(2018) PLoS One 13: e0209437
MeSH Terms: Antibodies, Neutralizing, Antibody Diversity, B-Lymphocytes, Cells, Cultured, Epitope Mapping, Epitopes, HIV Antibodies, HIV Infections, HIV-1, Humans, Hybridomas, Neutralization Tests, env Gene Products, Human Immunodeficiency Virus
Added March 31, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.
Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, Georgiev IS, Joyce MG, Tomaras GD, Bonsignori M, Reed SG, Salazar A, Mascola JR, Moody MA, Cain DW, Centlivre M, Zurawski S, Zurawski G, Erickson HP, Kwong PD, Alam SM, Levy Y, Montefiori DC, Haynes BF
(2017) Cell Rep 21: 3681-3690
MeSH Terms: AIDS Vaccines, Amino Acid Sequence, Animals, Antibodies, Neutralizing, Disease Models, Animal, Epitopes, HIV Antibodies, HIV-1, Immunization, Macaca mulatta, Mice, Polysaccharides, Protein Multimerization, Rabbits, env Gene Products, Human Immunodeficiency Virus
Added March 14, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.
Joyce MG, Georgiev IS, Yang Y, Druz A, Geng H, Chuang GY, Kwon YD, Pancera M, Rawi R, Sastry M, Stewart-Jones GBE, Zheng A, Zhou T, Choe M, Van Galen JG, Chen RE, Lees CR, Narpala S, Chambers M, Tsybovsky Y, Baxa U, McDermott AB, Mascola JR, Kwong PD
(2017) Cell Rep 21: 2992-3002
MeSH Terms: AIDS Vaccines, Enzyme-Linked Immunosorbent Assay, HIV-1, Microscopy, Electron, env Gene Products, Human Immunodeficiency Virus
Added March 14, 2018
0 Communities
1 Members
0 Resources
5 MeSH Terms
Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O'Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM
(2017) Immunity 46: 777-791.e10
MeSH Terms: Amino Acid Sequence, Antibodies, Neutralizing, B-Lymphocytes, Binding Sites, Complementarity Determining Regions, HIV Antibodies, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Models, Molecular, Peptide Fragments, Phylogeny, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Multimerization, Vaccines, Virus-Like Particle, env Gene Products, Human Immunodeficiency Virus
Added March 14, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
Zhou T, Doria-Rose NA, Cheng C, Stewart-Jones GBE, Chuang GY, Chambers M, Druz A, Geng H, McKee K, Kwon YD, O'Dell S, Sastry M, Schmidt SD, Xu K, Chen L, Chen RE, Louder MK, Pancera M, Wanninger TG, Zhang B, Zheng A, Farney SK, Foulds KE, Georgiev IS, Joyce MG, Lemmin T, Narpala S, Rawi R, Soto C, Todd JP, Shen CH, Tsybovsky Y, Yang Y, Zhao P, Haynes BF, Stamatatos L, Tiemeyer M, Wells L, Scorpio DG, Shapiro L, McDermott AB, Mascola JR, Kwong PD
(2017) Cell Rep 19: 719-732
MeSH Terms: Animals, Antibodies, Neutralizing, Antibody Specificity, Binding Sites, CD4 Antigens, Crystallography, X-Ray, Epitopes, Glycosylation, Guinea Pigs, HIV Antibodies, HIV-1, Humans, Immunization, Macaca mulatta, Molecular Dynamics Simulation, Polysaccharides, Protein Structure, Quaternary, env Gene Products, Human Immunodeficiency Virus
Added May 3, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
Chuang GY, Geng H, Pancera M, Xu K, Cheng C, Acharya P, Chambers M, Druz A, Tsybovsky Y, Wanninger TG, Yang Y, Doria-Rose NA, Georgiev IS, Gorman J, Joyce MG, O'Dell S, Zhou T, McDermott AB, Mascola JR, Kwong PD
(2017) J Virol 91:
MeSH Terms: AIDS Vaccines, Animals, Antibodies, Neutralizing, CD4 Antigens, Guinea Pigs, HIV Antibodies, HIV Antigens, HIV-1, Humans, Protein Multimerization, Protein Stability, env Gene Products, Human Immunodeficiency Virus
Added May 3, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.
Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JE
(2016) PLoS One 11: e0158861
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, HIV Antibodies, HIV Envelope Protein gp41, HIV Infections, HIV-1, Humans, Immunodominant Epitopes, Protein Domains, Recombinant Proteins, env Gene Products, Human Immunodeficiency Virus
Added April 13, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.
Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, Kwon YD, Pancera M, Taft J, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CC, Wu CY, Bewley CA, Burton DR, Koff WC, Connors M, Crispin M, Baxa U, Korber BT, Wong CH, Mascola JR, Kwong PD
(2016) Cell 165: 813-26
MeSH Terms: Antibodies, Neutralizing, Antibodies, Viral, Crystallography, X-Ray, Glycosylation, HIV-1, Immune Evasion, Models, Molecular, Molecular Dynamics Simulation, Polysaccharides, env Gene Products, Human Immunodeficiency Virus
Added May 3, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.
Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE
(2016) Mol Immunol 70: 94-103
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, Cell Separation, Enzyme-Linked Immunosorbent Assay, Epitopes, Flow Cytometry, Genes, Immunoglobulin, HIV Antibodies, HIV Infections, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Mutation, env Gene Products, Human Immunodeficiency Virus
Added January 26, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
Envelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits.
Malherbe DC, Pissani F, Sather DN, Guo B, Pandey S, Sutton WF, Stuart AB, Robins H, Park B, Krebs SJ, Schuman JT, Kalams S, Hessell AJ, Haigwood NL
(2014) J Virol 88: 12949-67
MeSH Terms: AIDS Vaccines, Animals, Antibodies, Neutralizing, Female, HIV Antibodies, HIV Infections, HIV-1, Humans, Molecular Sequence Data, RNA, Viral, Rabbits, Sequence Analysis, DNA, env Gene Products, Human Immunodeficiency Virus
Added January 20, 2015
0 Communities
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13 MeSH Terms