Modulating protein quality control.
Plate L, Paxman RJ, Wiseman RL, Kelly JW
(2016) Elife 5
: MeSH Terms: Activating Transcription Factor 6, Humans, Proteostasis Deficiencies, Unfolded Protein Response, eIF-2 KinaseAdded March 3, 2020
Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction.
Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM
(2014) Arthritis Rheumatol 66
: 2947-57MeSH Terms: Adult, Antirheumatic Agents, Arthritis, Rheumatoid, Cell Line, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, DNA-Activated Protein Kinase, Dose-Response Relationship, Drug, Female, Humans, Male, Methotrexate, Middle Aged, Monocytes, NF-kappa B, Nuclear Proteins, RNA, Long Noncoding, T-Lymphocytes, Tumor Suppressor Protein p53, eIF-2 KinaseAdded January 21, 2015
20 MeSH Terms
Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.
Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR
(2014) Eur J Pharmacol 724
: 193-203MeSH Terms: Animals, Apoptosis, Benzoxazoles, Caspases, Cell Line, Tumor, Fever, Ligands, Methamphetamine, Mice, Necrosis, Neuroprotective Agents, Piperazines, Reactive Nitrogen Species, Reactive Oxygen Species, Receptors, sigma, eIF-2 KinaseAdded August 26, 2015
16 MeSH Terms
Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication.
Lindquist ME, Mainou BA, Dermody TS, Crowe JE
(2011) Virology 413
: 103-10MeSH Terms: Cell Line, Cytoplasmic Granules, Enzyme Activation, Humans, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, Virus Replication, eIF-2 KinaseAdded December 10, 2013
8 MeSH Terms
The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.
Sen A, Pruijssers AJ, Dermody TS, García-Sastre A, Greenberg HB
(2011) J Virol 85
: 3717-32MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, DEAD Box Protein 58, DEAD-box RNA Helicases, Gene Deletion, Gene Expression Regulation, Interferon Regulatory Factor-3, Interferon-Induced Helicase, IFIH1, Interferon-beta, Mice, Mice, Knockout, Rotavirus, eIF-2 KinaseAdded December 10, 2013
13 MeSH Terms
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.
Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S
(2010) Neoplasia 12
: 61-8MeSH Terms: Animals, Apoptosis, Blotting, Western, Cell Hypoxia, Cell Survival, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, Embryo, Mammalian, Eukaryotic Initiation Factor-2, Fibroblasts, G1 Phase, Mice, Mice, Knockout, Phosphorylation, Protein Serine-Threonine Kinases, Tumor Suppressor Protein p53, eIF-2 KinaseAdded June 14, 2013
17 MeSH Terms
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.
Iida K, Li Y, McGrath BC, Frank A, Cavener DR
(2007) BMC Cell Biol 8
: 38MeSH Terms: Animals, Cell Death, Female, Male, Mice, Mice, Knockout, Pancreas, Exocrine, Pancreatitis, Tissue Survival, eIF-2 KinaseAdded August 13, 2010
10 MeSH Terms
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
(2006) Cell Metab 4
: 491-7MeSH Terms: Animals, Animals, Newborn, Cell Differentiation, Cell Proliferation, Diabetes Mellitus, Fetus, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Glucose, Homeostasis, Humans, Infant, Newborn, Insulin-Secreting Cells, Mice, Mice, Knockout, Proinsulin, eIF-2 KinaseAdded August 13, 2010
17 MeSH Terms
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC
(2004) Mol Cell Biol 24
: 1365-77MeSH Terms: Activating Transcription Factor 3, Activating Transcription Factor 4, Animals, CCAAT-Enhancer-Binding Proteins, Eukaryotic Initiation Factor-2, Mice, Phosphorylation, Phosphotransferases, Protein Kinases, Protein Serine-Threonine Kinases, RNA, Messenger, Transcription Factor CHOP, Transcription Factors, eIF-2 KinaseAdded August 13, 2010
14 MeSH Terms
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR
(2002) Mol Cell Biol 22
: 3864-74MeSH Terms: Animals, Apoptosis, Bone Development, Bone Diseases, Developmental, Cell Survival, Collagen Type I, Diabetes Mellitus, Endoplasmic Reticulum, Rough, Eukaryotic Initiation Factor-2, Gene Expression, Glucose, Growth Disorders, Humans, Mice, Mice, Knockout, Pancreas, Phosphorylation, eIF-2 KinaseAdded January 6, 2014
18 MeSH Terms