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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 10

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Modulating protein quality control.
Plate L, Paxman RJ, Wiseman RL, Kelly JW
(2016) Elife 5:
MeSH Terms: Activating Transcription Factor 6, Humans, Proteostasis Deficiencies, Unfolded Protein Response, eIF-2 Kinase
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction.
Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM
(2014) Arthritis Rheumatol 66: 2947-57
MeSH Terms: Adult, Antirheumatic Agents, Arthritis, Rheumatoid, Cell Line, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, DNA-Activated Protein Kinase, Dose-Response Relationship, Drug, Female, Humans, Male, Methotrexate, Middle Aged, Monocytes, NF-kappa B, Nuclear Proteins, RNA, Long Noncoding, T-Lymphocytes, Tumor Suppressor Protein p53, eIF-2 Kinase
Added January 21, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.
Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR
(2014) Eur J Pharmacol 724: 193-203
MeSH Terms: Animals, Apoptosis, Benzoxazoles, Caspases, Cell Line, Tumor, Fever, Ligands, Methamphetamine, Mice, Necrosis, Neuroprotective Agents, Piperazines, Reactive Nitrogen Species, Reactive Oxygen Species, Receptors, sigma, eIF-2 Kinase
Added August 26, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication.
Lindquist ME, Mainou BA, Dermody TS, Crowe JE
(2011) Virology 413: 103-10
MeSH Terms: Cell Line, Cytoplasmic Granules, Enzyme Activation, Humans, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, Virus Replication, eIF-2 Kinase
Added December 10, 2013
0 Communities
2 Members
0 Resources
8 MeSH Terms
The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.
Sen A, Pruijssers AJ, Dermody TS, García-Sastre A, Greenberg HB
(2011) J Virol 85: 3717-32
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, DEAD Box Protein 58, DEAD-box RNA Helicases, Gene Deletion, Gene Expression Regulation, Interferon Regulatory Factor-3, Interferon-Induced Helicase, IFIH1, Interferon-beta, Mice, Mice, Knockout, Rotavirus, eIF-2 Kinase
Added December 10, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.
Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S
(2010) Neoplasia 12: 61-8
MeSH Terms: Animals, Apoptosis, Blotting, Western, Cell Hypoxia, Cell Survival, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, Embryo, Mammalian, Eukaryotic Initiation Factor-2, Fibroblasts, G1 Phase, Mice, Mice, Knockout, Phosphorylation, Protein Serine-Threonine Kinases, Tumor Suppressor Protein p53, eIF-2 Kinase
Added June 14, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.
Iida K, Li Y, McGrath BC, Frank A, Cavener DR
(2007) BMC Cell Biol 8: 38
MeSH Terms: Animals, Cell Death, Female, Male, Mice, Mice, Knockout, Pancreas, Exocrine, Pancreatitis, Tissue Survival, eIF-2 Kinase
Added August 13, 2010
1 Communities
0 Members
0 Resources
10 MeSH Terms
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
(2006) Cell Metab 4: 491-7
MeSH Terms: Animals, Animals, Newborn, Cell Differentiation, Cell Proliferation, Diabetes Mellitus, Fetus, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Glucose, Homeostasis, Humans, Infant, Newborn, Insulin-Secreting Cells, Mice, Mice, Knockout, Proinsulin, eIF-2 Kinase
Added August 13, 2010
1 Communities
0 Members
0 Resources
17 MeSH Terms
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC
(2004) Mol Cell Biol 24: 1365-77
MeSH Terms: Activating Transcription Factor 3, Activating Transcription Factor 4, Animals, CCAAT-Enhancer-Binding Proteins, Eukaryotic Initiation Factor-2, Mice, Phosphorylation, Phosphotransferases, Protein Kinases, Protein Serine-Threonine Kinases, RNA, Messenger, Transcription Factor CHOP, Transcription Factors, eIF-2 Kinase
Added August 13, 2010
1 Communities
0 Members
0 Resources
14 MeSH Terms
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR
(2002) Mol Cell Biol 22: 3864-74
MeSH Terms: Animals, Apoptosis, Bone Development, Bone Diseases, Developmental, Cell Survival, Collagen Type I, Diabetes Mellitus, Endoplasmic Reticulum, Rough, Eukaryotic Initiation Factor-2, Gene Expression, Glucose, Growth Disorders, Humans, Mice, Mice, Knockout, Pancreas, Phosphorylation, eIF-2 Kinase
Added January 6, 2014
2 Communities
1 Members
0 Resources
18 MeSH Terms