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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
(2021) Cell Rep 37: 109813
MeSH Terms: Animals, Animals, Genetically Modified, Blood Glucose, Calcium Signaling, Cell Line, Cellular Senescence, DNA Damage, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Insulin, Insulin-Secreting Cells, Maf Transcription Factors, Large, Male, Mice, Inbred C57BL, Mutation, Missense, Phenotype, Sex Characteristics, Sex Factors
Added November 23, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
Factors Associated With COVID-19 Disease Severity in US Children and Adolescents.
Antoon JW, Grijalva CG, Thurm C, Richardson T, Spaulding AB, Teufel RJ, Reyes MA, Shah SS, Burns JE, Kenyon CC, Hersh AL, Williams DJ
(2021) J Hosp Med 16: 603-610
MeSH Terms: Adolescent, COVID-19, Child, Child, Preschool, Diabetes Mellitus, Type 2, Humans, Retrospective Studies, SARS-CoV-2, Severity of Illness Index
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young.
Graff SM, Johnson SR, Leo PJ, Dadi PK, Dickerson MT, Nakhe AY, McInerney-Leo AM, Marshall M, Zaborska KE, Schaub CM, Brown MA, Jacobson DA, Duncan EL
(2021) JCI Insight 6:
MeSH Terms: Animals, Blood Glucose, Calcium Signaling, Channelopathies, Diabetes Mellitus, Type 2, Gain of Function Mutation, Humans, Insulin Secretion, Insulin-Secreting Cells, Membrane Potentials, Mice, Potassium Channels, Tandem Pore Domain
Added June 14, 2021
0 Communities
1 Members
0 Resources
12 MeSH Terms
Response to Comment on Gregory et al. COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic's Impact in Type 1 and Type 2 Diabetes. Diabetes Care 2021;44:526-532.
Gregory JM, Slaughter JC, Duffus SH, Smith TJ, LeStourgeon LM, Jaser SS, McCoy AB, Luther JM, Giovannetti ER, Boeder S, Pettus JH, Moore DJ
(2021) Diabetes Care 44: e103-e104
MeSH Terms: COVID-19, Diabetes Mellitus, Type 2, Humans, Pandemics, Prospective Studies, SARS-CoV-2
Added May 12, 2021
0 Communities
2 Members
0 Resources
6 MeSH Terms
Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.
de Goede OM, Nachun DC, Ferraro NM, Gloudemans MJ, Rao AS, Smail C, Eulalio TY, Aguet F, Ng B, Xu J, Barbeira AN, Castel SE, Kim-Hellmuth S, Park Y, Scott AJ, Strober BJ, GTEx Consortium, Brown CD, Wen X, Hall IM, Battle A, Lappalainen T, Im HK, Ardlie KG, Mostafavi S, Quertermous T, Kirkegaard K, Montgomery SB
(2021) Cell 184: 2633-2648.e19
MeSH Terms: Coronary Artery Disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease, Gene Expression Profiling, Genetic Variation, Humans, Inflammatory Bowel Diseases, Multifactorial Inheritance, Organ Specificity, Population, Quantitative Trait Loci, RNA, Long Noncoding, Transcriptome
Added April 18, 2021
0 Communities
1 Members
0 Resources
14 MeSH Terms
The Rapid Transition to Telemedicine and Its Effect on Access to Care for Patients With Type 1 Diabetes During the COVID-19 Pandemic.
Tilden DR, Datye KA, Moore DJ, French B, Jaser SS
(2021) Diabetes Care 44: 1447-1450
MeSH Terms: COVID-19, Child, Diabetes Mellitus, Type 1, Health Services Accessibility, Humans, Pandemics, SARS-CoV-2, Telemedicine, United States
Added April 15, 2021
0 Communities
1 Members
0 Resources
9 MeSH Terms
The Dual Burden of Type 1 Diabetes and COVID-19.
Gregory JM, Moore DJ
(2021) Ann Intern Med 174: 703-704
MeSH Terms: COVID-19, COVID-19 Vaccines, Diabetes Mellitus, Type 1, Hospitalization, Humans, SARS-CoV-2, United States
Added January 28, 2021
0 Communities
2 Members
0 Resources
7 MeSH Terms
COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic's Impact in Type 1 and Type 2 Diabetes.
Gregory JM, Slaughter JC, Duffus SH, Smith TJ, LeStourgeon LM, Jaser SS, McCoy AB, Luther JM, Giovannetti ER, Boeder S, Pettus JH, Moore DJ
(2021) Diabetes Care 44: 526-532
MeSH Terms: COVID-19, Comorbidity, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Electronic Health Records, Female, Hospitalization, Humans, Hypertension, Male, Middle Aged, Odds Ratio, Prospective Studies, Severity of Illness Index
Added December 7, 2020
0 Communities
2 Members
0 Resources
14 MeSH Terms
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Bonami RH, Nyhoff LE, McNitt DH, Hulbert C, Felton JL, Kendall PL, Thomas JW
(2020) J Immunol 205: 3263-3276
MeSH Terms: Animals, Autoantibodies, B-Lymphocytes, Cell Communication, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Mice, Mice, Inbred NOD, Mice, Transgenic, Signaling Lymphocytic Activation Molecule Associated Protein, Th1 Cells
Added December 1, 2020
1 Communities
0 Members
0 Resources
11 MeSH Terms
Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
Bachmann KN, Roumie CL, Wiese AD, Grijalva CG, Buse JB, Bradford R, Zalimeni EO, Knoepp P, Dard S, Morris HL, Donahoo WT, Fanous N, Fonseca V, Katalenich B, Choi S, Louzao D, O'Brien E, Cook MM, Rothman RL, Chakkalakal RJ
(2020) Pharmacol Res Perspect 8: e00637
MeSH Terms: Adult, Aged, Comorbidity, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Drug Therapy, Combination, Electronic Health Records, Female, Glucagon-Like Peptide-1 Receptor, Humans, Hyperlipidemias, Hypertension, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Patient-Centered Care, Retrospective Studies, Sodium-Glucose Transporter 2 Inhibitors, Sulfonylurea Compounds, Thiazolidinediones, United States
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms