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Results: 1 to 7 of 7

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Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches.
Lu LX, Domingo-Sananes MR, Huzarska M, Novak B, Gould KL
(2012) Proc Natl Acad Sci U S A 109: 9899-904
MeSH Terms: Animals, CDC2 Protein Kinase, Cell Cycle, Enzyme Activation, Humans, Mitosis, Phosphorylation, Xenopus, cdc25 Phosphatases
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
Liu Y, Bertram CC, Shi Q, Zinkel SS
(2011) Cell Death Differ 18: 841-52
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Motifs, Amino Acid Sequence, Animals, Ataxia Telangiectasia Mutated Proteins, BH3 Interacting Domain Death Agonist Protein, Bone Marrow Cells, Caspase 8, Cell Cycle Proteins, Cell Line, Cell Proliferation, Checkpoint Kinase 1, Chromatin, Consensus Sequence, DNA Damage, DNA Replication, DNA-Binding Proteins, Gene Deletion, Humans, Hydroxyurea, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Mutation, Missense, Phosphorylation, Protein Binding, Protein Interaction Domains and Motifs, Protein Kinases, Protein Serine-Threonine Kinases, RNA Interference, Replication Protein A, Signal Transduction, Stress, Physiological, cdc25 Phosphatases
Added September 7, 2011
1 Communities
1 Members
0 Resources
35 MeSH Terms
Inactivating Cdc25, mitotic style.
Wolfe BA, Gould KL
(2004) Cell Cycle 3: 601-3
MeSH Terms: Animals, CDC2 Protein Kinase, Cyclin B, Enzyme Activation, Mitosis, Saccharomyces cerevisiae Proteins, Xenopus laevis, cdc25 Phosphatases
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest.
Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL
(2003) Proc Natl Acad Sci U S A 100: 15548-53
MeSH Terms: 3T3 Cells, Animals, Cell Cycle, Cell Division, Cell Line, Epithelial Cells, Female, Intracellular Signaling Peptides and Proteins, Mammary Glands, Animal, Mice, Phosphorylation, Protein Serine-Threonine Kinases, Transforming Growth Factor beta, cdc25 Phosphatases, rho-Associated Kinases, rhoA GTP-Binding Protein
Added February 17, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.
Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H
(2003) J Biol Chem 278: 21767-73
MeSH Terms: Antineoplastic Agents, Phytogenic, Blotting, Western, Camptothecin, Cell Cycle, Cell Separation, Checkpoint Kinase 1, DNA Damage, Dose-Response Relationship, Drug, Doxorubicin, Enzyme Inhibitors, Flow Cytometry, G2 Phase, Humans, Phosphorylation, Protein Kinases, RNA, Small Interfering, S Phase, Time Factors, Transfection, Tumor Cells, Cultured, Tyrosine, Ultraviolet Rays, cdc25 Phosphatases
Added March 5, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.
Graves PR, Lovly CM, Uy GL, Piwnica-Worms H
(2001) Oncogene 20: 1839-51
MeSH Terms: 14-3-3 Proteins, Active Transport, Cell Nucleus, Alkaloids, Amino Acid Sequence, Cell Cycle Proteins, Cytoplasm, Fatty Acids, Unsaturated, HeLa Cells, Humans, Molecular Sequence Data, Protein Binding, Staurosporine, Tyrosine 3-Monooxygenase, cdc25 Phosphatases
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2.
Den Haese GJ, Walworth N, Carr AM, Gould KL
(1995) Mol Biol Cell 6: 371-85
MeSH Terms: Base Sequence, Cell Cycle Proteins, Checkpoint Kinase 1, G2 Phase, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Fungal, Genes, Fungal, Molecular Sequence Data, Mutagenesis, Site-Directed, Nuclear Proteins, Phosphoprotein Phosphatases, Phosphorylation, Protein Kinases, Protein-Tyrosine Kinases, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Threonine, Tyrosine, cdc25 Phosphatases
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms