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Results: 1 to 9 of 9

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HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Zhou J, Price AJ, Halambage UD, James LC, Aiken C
(2015) J Virol 89: 9068-79
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Binding Sites, CD4-Positive T-Lymphocytes, Capsid, Capsid Proteins, Cell Line, Drug Resistance, Viral, HIV Infections, HIV-1, Host-Pathogen Interactions, Humans, Indoles, Macrophages, Molecular Chaperones, Nuclear Pore Complex Proteins, Phenylalanine, Protein Binding, Protein Conformation, RNA Interference, RNA, Small Interfering, Virus Internalization, Virus Replication, beta Karyopherins, mRNA Cleavage and Polyadenylation Factors
Added February 4, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
Normal telomere length maintenance in Saccharomyces cerevisiae requires nuclear import of the ever shorter telomeres 1 (Est1) protein via the importin alpha pathway.
Hawkins C, Friedman KL
(2014) Eukaryot Cell 13: 1036-50
MeSH Terms: Active Transport, Cell Nucleus, Amino Acid Sequence, Cell Nucleus, Molecular Sequence Data, Nuclear Localization Signals, Nucleocytoplasmic Transport Proteins, RNA-Binding Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Telomerase, Telomere Homeostasis, beta Karyopherins
Added January 20, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.
Shah VB, Shi J, Hout DR, Oztop I, Krishnan L, Ahn J, Shotwell MS, Engelman A, Aiken C
(2013) J Virol 87: 422-32
MeSH Terms: Cell Line, Cyclophilin A, HIV-1, Host-Pathogen Interactions, Humans, Virus Uncoating, beta Karyopherins
Added May 27, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex.
Terry LJ, Wente SR
(2007) J Cell Biol 178: 1121-32
MeSH Terms: Active Transport, Cell Nucleus, Cell Nucleus, Mutation, Nuclear Pore, Nuclear Pore Complex Proteins, Nuclear Proteins, Nucleocytoplasmic Transport Proteins, Poly A, Protein Binding, Protein Structure, Tertiary, Protein Transport, RNA Transport, RNA, Messenger, RNA-Binding Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Structure-Activity Relationship, Temperature, beta Karyopherins
Added March 21, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo.
Ryan KJ, Zhou Y, Wente SR
(2007) Mol Biol Cell 18: 886-98
MeSH Terms: Alleles, Cell Membrane, Cytoplasm, Genetic Testing, Glutamine, Lysine, Models, Biological, Mutant Proteins, Nuclear Pore, Nuclear Pore Complex Proteins, Phenotype, Protein Binding, Protein Transport, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Temperature, beta Karyopherins, ran GTP-Binding Protein
Added March 21, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Minimal nuclear pore complexes define FG repeat domains essential for transport.
Strawn LA, Shen T, Shulga N, Goldfarb DS, Wente SR
(2004) Nat Cell Biol 6: 197-206
MeSH Terms: Active Transport, Cell Nucleus, Cell Membrane Permeability, Cell Survival, Cells, Cultured, Gene Deletion, Karyopherins, Mutation, Nuclear Pore, Nuclear Pore Complex Proteins, Protein Structure, Tertiary, Protein Transport, Repetitive Sequences, Amino Acid, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, beta Karyopherins
Added March 21, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.
Bayliss R, Littlewood T, Strawn LA, Wente SR, Stewart M
(2002) J Biol Chem 277: 50597-606
MeSH Terms: Active Transport, Cell Nucleus, Amino Acid Sequence, Animals, Binding Sites, Cloning, Molecular, Crystallography, X-Ray, Dogs, Kinetics, Models, Molecular, Nuclear Pore Complex Proteins, Peptide Fragments, Protein Conformation, Protein Structure, Secondary, Recombinant Proteins, Saccharomyces cerevisiae, beta Karyopherins
Added March 21, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex.
Strawn LA, Shen T, Wente SR
(2001) J Biol Chem 276: 6445-52
MeSH Terms: Amino Acid Motifs, Binding Sites, Green Fluorescent Proteins, Luminescent Proteins, Membrane Proteins, Nuclear Pore, Nuclear Pore Complex Proteins, Nuclear Proteins, Nucleocytoplasmic Transport Proteins, Oligopeptides, RNA, Messenger, RNA-Binding Proteins, Repetitive Sequences, Amino Acid, Saccharomyces cerevisiae Proteins, beta Karyopherins
Added March 21, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p.
Iovine MK, Wente SR
(1997) J Cell Biol 137: 797-811
MeSH Terms: Amino Acid Sequence, Biological Transport, Cell Nucleus, Fungal Proteins, Membrane Proteins, Microscopy, Confocal, Nuclear Pore Complex Proteins, Nuclear Proteins, Protein Binding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Structure-Activity Relationship, beta Karyopherins
Added March 21, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms