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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 56

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Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.
Williams MM, Lee L, Werfel T, Joly MMM, Hicks DJ, Rahman B, Elion D, McKernan C, Sanchez V, Estrada MV, Massarweh S, Elledge R, Duvall C, Cook RS
(2018) Cell Death Dis 9: 21
MeSH Terms: Aniline Compounds, Animals, Apoptosis, Breast Neoplasms, Cell Line, Tumor, Down-Regulation, Estrogen Antagonists, Female, Fulvestrant, Gene Targeting, Humans, Mice, Myeloid Cell Leukemia Sequence 1 Protein, Receptors, Estrogen, Signal Transduction, Sulfonamides, Up-Regulation, bcl-X Protein
Added March 14, 2018
0 Communities
2 Members
0 Resources
18 MeSH Terms
Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade.
Williams MM, Lee L, Hicks DJ, Joly MM, Elion D, Rahman B, McKernan C, Sanchez V, Balko JM, Stricker T, Estrada MV, Cook RS
(2017) Mol Cancer Res 15: 259-268
MeSH Terms: Aniline Compounds, Antineoplastic Agents, Breast Neoplasms, Cell Line, Tumor, Cell Survival, Estrogen Receptor alpha, Female, Humans, MCF-7 Cells, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasms, Proto-Oncogene Proteins c-bcl-2, RNA, Messenger, Sulfonamides, bcl-X Protein
Added April 6, 2017
0 Communities
2 Members
0 Resources
15 MeSH Terms
Histone Deacetylase 3 Is Required for Efficient T Cell Development.
Stengel KR, Zhao Y, Klus NJ, Kaiser JF, Gordy LE, Joyce S, Hiebert SW, Summers AR
(2015) Mol Cell Biol 35: 3854-65
MeSH Terms: Animals, CD4 Antigens, CD4-Positive T-Lymphocytes, CD8 Antigens, CD8-Positive T-Lymphocytes, Cell Differentiation, Gene Deletion, Gene Expression Regulation, Developmental, Histone Deacetylases, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Proto-Oncogene Proteins c-bcl-2, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, bcl-X Protein
Added September 28, 2015
1 Communities
2 Members
0 Resources
18 MeSH Terms
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.
Burke JP, Bian Z, Shaw S, Zhao B, Goodwin CM, Belmar J, Browning CF, Vigil D, Friberg A, Camper DV, Rossanese OW, Lee T, Olejniczak ET, Fesik SW
(2015) J Med Chem 58: 3794-805
MeSH Terms: Crystallography, X-Ray, Heterocyclic Compounds, 3-Ring, Humans, Indoles, K562 Cells, Models, Molecular, Molecular Conformation, Myeloid Cell Leukemia Sequence 1 Protein, Protein Binding, Structure-Activity Relationship, bcl-X Protein
Added February 11, 2016
1 Communities
1 Members
0 Resources
11 MeSH Terms
Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer.
Bhola NE, Jansen VM, Bafna S, Giltnane JM, Balko JM, Estrada MV, Meszoely I, Mayer I, Abramson V, Ye F, Sanders M, Dugger TC, Allen EV, Arteaga CL
(2015) Cancer Res 75: 405-14
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cell Cycle Proteins, Drug Synergism, Estradiol, Estrogen Receptor alpha, Female, Fulvestrant, Humans, MCF-7 Cells, Mice, Mice, Nude, Neoplasms, Hormone-Dependent, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Pteridines, RNA, Small Interfering, Random Allocation, Transcription Factors, Transcription, Genetic, Xenograft Model Antitumor Assays, bcl-X Protein
Added January 20, 2015
0 Communities
2 Members
0 Resources
23 MeSH Terms
Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.
Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR
(2013) J Neurosci 33: 18098-108
MeSH Terms: Animals, Apoptosis, Cells, Cultured, Female, Male, Medulloblastoma, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Knockout, Neural Stem Cells, Protein Binding, Time Factors, bcl-2-Associated X Protein, bcl-X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW
(2013) J Med Chem 56: 15-30
MeSH Terms: Antineoplastic Agents, Crystallography, X-Ray, Databases, Factual, Drug Design, Humans, Indoles, Ligands, Magnetic Resonance Spectroscopy, Molecular Docking Simulation, Molecular Structure, Myeloid Cell Leukemia Sequence 1 Protein, Protein Binding, Proto-Oncogene Proteins c-bcl-2, Small Molecule Libraries, Structure-Activity Relationship, bcl-X Protein
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xL.
Zhan Z, He K, Zhu D, Jiang D, Huang YH, Li Y, Sun C, Jin YH
(2012) PLoS One 7: e44923
MeSH Terms: Active Transport, Cell Nucleus, Apoptosis, Biocatalysis, Cell Cycle Proteins, Cell Nucleus, Cyclin A, Cyclin-Dependent Kinase 2, Etoposide, HeLa Cells, Humans, Mitochondria, Phosphorylation, RNA Interference, Serine, Signal Transduction, Topoisomerase II Inhibitors, Up-Regulation, bcl-X Protein
Added July 28, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Resistance to TRAIL is mediated by DARPP-32 in gastric cancer.
Belkhiri A, Zhu S, Chen Z, Soutto M, El-Rifai W
(2012) Clin Cancer Res 18: 3889-900
MeSH Terms: Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Caspases, Cell Line, Tumor, Cell Transformation, Neoplastic, Dopamine and cAMP-Regulated Phosphoprotein 32, Gene Expression Regulation, Neoplastic, Humans, NF-kappa B, Signal Transduction, Stomach Neoplasms, TNF-Related Apoptosis-Inducing Ligand, bcl-X Protein
Added September 3, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms
Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK).
Shajahan AN, Dobbin ZC, Hickman FE, Dakshanamurthy S, Clarke R
(2012) J Biol Chem 287: 17682-17692
MeSH Terms: Amino Acid Substitution, Antineoplastic Agents, Phytogenic, Apoptosis, Breast Neoplasms, Caveolin 1, Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Female, Humans, MAP Kinase Kinase 4, Mitochondria, Mutation, Missense, Paclitaxel, Phosphorylation, Protein Structure, Tertiary, bcl-X Protein
Added August 14, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms