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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.
Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF
(2016) Arterioscler Thromb Vasc Biol 36: 1122-31
MeSH Terms: Animals, Aorta, Aortic Diseases, Apoptosis, Atherosclerosis, Bone Marrow Cells, Bone Marrow Transplantation, Cell Survival, Cells, Cultured, Diet, High-Fat, Disease Models, Animal, Endoplasmic Reticulum Stress, Genetic Predisposition to Disease, Hypercholesterolemia, Macrophages, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, PTEN Phosphohydrolase, Phenotype, Plaque, Atherosclerotic, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Receptors, LDL, Signal Transduction, bcl-Associated Death Protein
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
The Bcl-2-associated death promoter (BAD) lowers the threshold at which the Bcl-2-interacting domain death agonist (BID) triggers mitochondria disintegration.
Howells CC, Baumann WT, Samuels DC, Finkielstein CV
(2011) J Theor Biol 271: 114-23
MeSH Terms: Algorithms, Animals, Apoptosis, BH3 Interacting Domain Death Agonist Protein, Mitochondria, Models, Biological, Phosphorylation, Signal Transduction, bcl-Associated Death Protein
Added December 12, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms
RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells.
Flynn JM, Lannigan DA, Clark DE, Garner MH, Cammarata PR
(2008) Am J Physiol Endocrinol Metab 294: E589-99
MeSH Terms: Cell Line, Cyclic AMP-Dependent Protein Kinases, Enzyme Activation, Epithelial Cells, Estradiol, Humans, Lens, Crystalline, Membrane Potential, Mitochondrial, Mitogen-Activated Protein Kinase 1, Oxidative Stress, Phosphorylation, RNA, Small Interfering, Serine, bcl-Associated Death Protein
Added January 20, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.
Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W
(2007) PLoS Med 4: e294
MeSH Terms: Adenocarcinoma, Animals, Apoptosis, Cell Differentiation, Cell Line, Tumor, Cells, Cultured, Disease Models, Animal, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Flow Cytometry, Fluorescent Antibody Technique, Humans, Lung Neoplasms, Mice, Mutation, Quinazolines, Sensitivity and Specificity, bcl-Associated Death Protein
Added March 24, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.
Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS
(2007) Diabetes 56: 2569-78
MeSH Terms: Animals, Calcium, Cell Culture Techniques, Glucose, Insulin, Insulin Secretion, Insulin-Secreting Cells, Ion Channels, Islets of Langerhans, Magnesium, Male, Membrane Potentials, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Confocal, Mitochondrial Membranes, Mitochondrial Proteins, Uncoupling Protein 2, bcl-Associated Death Protein
Added July 22, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Structural biology of the Bcl-2 family of proteins.
Petros AM, Olejniczak ET, Fesik SW
(2004) Biochim Biophys Acta 1644: 83-94
MeSH Terms: Amino Acid Sequence, Apoptosis Regulatory Proteins, BH3 Interacting Domain Death Agonist Protein, Carrier Proteins, Membrane Proteins, Models, Molecular, Molecular Sequence Data, Oncogene Proteins, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Sequence Alignment, Viral Proteins, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, bcl-Associated Death Protein, bcl-X Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR.
Petros AM, Gunasekera A, Xu N, Olejniczak ET, Fesik SW
(2004) FEBS Lett 559: 171-4
MeSH Terms: Binding Sites, Carrier Proteins, DNA, Complementary, Gene Library, Humans, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Peptide Fragments, Tumor Suppressor Protein p53, bcl-Associated Death Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E
(2003) Mol Cell Biol 23: 6350-62
MeSH Terms: 14-3-3 Proteins, 3T3 Cells, Animals, Apoptosis, Binding Sites, Binding, Competitive, Carrier Proteins, Cells, Cultured, Enzyme Inhibitors, Humans, Marine Toxins, Mice, Mutation, Oxazoles, Phosphoprotein Phosphatases, Phosphorylation, Phosphoserine, Protein Phosphatase 2, Proto-Oncogene Proteins c-bcl-2, Tyrosine 3-Monooxygenase, bcl-Associated Death Protein, bcl-X Protein
Added January 23, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Rice PL, Washington M, Schleman S, Beard KS, Driggers LJ, Ahnen DJ
(2003) Cancer Res 63: 616-20
MeSH Terms: Antineoplastic Agents, Butadienes, Carrier Proteins, Caspase Inhibitors, Caspases, Colonic Neoplasms, Enzyme Activation, Epidermal Growth Factor, Humans, MAP Kinase Kinase 1, MAP Kinase Kinase 2, MAP Kinase Signaling System, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Nitriles, Phosphorylation, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, Sulindac, Tumor Cells, Cultured, bcl-Associated Death Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest.
Chattopadhyay A, Chiang CW, Yang E
(2001) Oncogene 20: 4507-18
MeSH Terms: Animals, Apoptosis, CDC2-CDC28 Kinases, Carrier Proteins, Cell Division, Cells, Cultured, Contact Inhibition, Culture Media, Serum-Free, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinases, DNA Replication, Dimerization, Enzyme Activation, Fibroblasts, G1 Phase, Phosphorylation, Protein Conformation, Protein Multimerization, Protein Processing, Post-Translational, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-bcl-2, Rats, Recombinant Fusion Proteins, Resting Phase, Cell Cycle, Structure-Activity Relationship, bcl-Associated Death Protein, bcl-X Protein
Added January 23, 2013
0 Communities
1 Members
0 Resources
27 MeSH Terms