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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 49

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Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A
(2017) Cancer Cell 31: 142-156
MeSH Terms: Age Factors, Animals, Apoptosis, Doxorubicin, Humans, Mice, Mitochondria, Neoplasms, Organ Specificity, Proto-Oncogene Proteins c-myc, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
Added March 26, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAX.
Fischer AW, Bordignon E, Bleicken S, García-Sáez AJ, Jeschke G, Meiler J
(2016) J Struct Biol 195: 62-71
MeSH Terms: Algorithms, Amino Acid Sequence, Animals, Electron Spin Resonance Spectroscopy, Humans, Models, Molecular, Molecular Structure, Protein Conformation, Protein Folding, Protein Multimerization, bcl-2-Associated X Protein
Added April 8, 2017
1 Communities
1 Members
0 Resources
11 MeSH Terms
Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.
Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR
(2013) J Neurosci 33: 18098-108
MeSH Terms: Animals, Apoptosis, Cells, Cultured, Female, Male, Medulloblastoma, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Knockout, Neural Stem Cells, Protein Binding, Time Factors, bcl-2-Associated X Protein, bcl-X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
He K, Zheng X, Zhang L, Yu J
(2013) Mol Cancer Ther 12: 2559-68
MeSH Terms: Animals, Apoptosis, Apoptosis Regulatory Proteins, Benzoquinones, Cell Line, Tumor, Colorectal Neoplasms, DNA Damage, HCT116 Cells, HSP90 Heat-Shock Proteins, Humans, Isoxazoles, Lactams, Macrocyclic, Mice, Mice, Nude, Mitochondria, Proto-Oncogene Proteins, Resorcinols, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, bcl-2-Associated X Protein
Added July 28, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Human embryonic stem cells: living on the edge.
Gama V, Deshmukh M
(2012) Cell Cycle 11: 3905-6
MeSH Terms: Apoptosis, Caspases, Cell Differentiation, Cytochromes c, DNA Damage, Embryonic Stem Cells, Golgi Apparatus, Humans, Mitochondria, bcl-2-Associated X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.
Garcia I, Crowther AJ, Gama V, Miller CR, Miller CR, Deshmukh M, Gershon TR
(2013) Oncogene 32: 2304-14
MeSH Terms: Animals, Apoptosis, Cell Differentiation, Cell Movement, Cerebellar Neoplasms, Cerebellum, Down-Regulation, Medulloblastoma, Mice, Mice, Transgenic, Neurogenesis, Proto-Oncogene Proteins c-bcl-2, Receptors, G-Protein-Coupled, Smoothened Receptor, Stem Cells, bcl-2-Associated X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis.
Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M
(2012) Mol Cell 46: 573-83
MeSH Terms: Acetylation, Antigens, Nuclear, Apoptosis, Biological Transport, DNA Damage, DNA-Binding Proteins, Embryonic Stem Cells, Gene Silencing, Genes, bcl-2, Golgi Apparatus, Humans, Ku Autoantigen, Mitochondria, Tumor Suppressor Protein p53, bcl-2-Associated X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor.
Leskov KS, Araki S, Lavik JP, Gomez JA, Gama V, Gonos ES, Trougakos IP, Matsuyama S, Boothman DA
(2011) J Biol Chem 286: 40083-90
MeSH Terms: Active Transport, Cell Nucleus, Animals, Antibiotics, Antineoplastic, Apoptosis, Cell Nucleus, Clusterin, Fatty Acids, Unsaturated, Gamma Rays, Humans, Karyopherins, Mice, Mice, Knockout, Protein Isoforms, Radiation Tolerance, Receptors, Cytoplasmic and Nuclear, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.
Li Q, Li Y, Wang X, Fang X, He K, Guo X, Zhan Z, Sun C, Jin YH
(2011) Mol Carcinog 50: 760-9
MeSH Terms: Antineoplastic Agents, Phytogenic, Apoptosis, BH3 Interacting Domain Death Agonist Protein, Blotting, Western, Caspase 3, Caspase 8, Caspase 9, Cell Line, Tumor, Cell Survival, Cytochromes c, Dose-Response Relationship, Drug, Drug Synergism, Enzyme Activation, Flow Cytometry, Ginsenosides, HeLa Cells, Hep G2 Cells, Humans, Molecular Structure, Neoplasms, Pentacyclic Triterpenes, Poly(ADP-ribose) Polymerases, Protein Transport, RNA Interference, Triterpenes, bcl-2-Associated X Protein
Added July 28, 2015
0 Communities
1 Members
0 Resources
26 MeSH Terms
Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside.
Ma J, Matsusaka T, Yang HC, Zhong J, Takagi N, Fogo AB, Kon V, Ichikawa I
(2011) Pediatr Res 70: 83-9
MeSH Terms: Actinin, Animals, Animals, Newborn, Apoptosis, Autocrine Communication, Caspase 3, Cells, Cultured, Desmin, Disease Models, Animal, Doxycycline, Glomerulonephritis, Humans, Intracellular Signaling Peptides and Proteins, Kidney Glomerulus, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microfilament Proteins, Podocytes, Puromycin Aminonucleoside, Response Elements, Vascular Endothelial Growth Factor A, bcl-2-Associated X Protein, bcl-X Protein
Added January 25, 2012
2 Communities
3 Members
0 Resources
25 MeSH Terms