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Results: 1 to 10 of 13

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Functional variants of the melanocortin-4 receptor associated with the Odontoceti and Mysticeti suborders of cetaceans.
Zhao L, Zhou X, Rokas A, Cone RD
(2017) Sci Rep 7: 5684
MeSH Terms: Amino Acid Sequence, Animals, Body Size, Cetacea, Evolution, Molecular, Feeding Behavior, Phylogeny, Receptor, Melanocortin, Type 4, alpha-MSH
Added March 21, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC
(2015) J Clin Endocrinol Metab 100: 1639-45
MeSH Terms: Adult, Anti-Obesity Agents, Combined Modality Therapy, Cross-Over Studies, Double-Blind Method, Energy Metabolism, Female, Humans, Male, Middle Aged, Obesity, Receptor, Melanocortin, Type 4, Rest, Weight Reduction Programs, Young Adult, alpha-MSH
Added February 4, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
(2015) Nature 520: 94-8
MeSH Terms: Action Potentials, Agouti-Related Protein, Animals, Eating, Energy Metabolism, Female, GTP-Binding Protein alpha Subunits, Gs, HEK293 Cells, Homeostasis, Humans, Ligands, Male, Melanocortins, Mice, Neurons, Paraventricular Hypothalamic Nucleus, Potassium Channels, Inwardly Rectifying, Receptor, Melanocortin, Type 4, Signal Transduction, alpha-MSH
Added February 4, 2016
0 Communities
2 Members
0 Resources
20 MeSH Terms
Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.
Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD
(2013) Science 341: 278-81
MeSH Terms: Animals, Embryo, Nonmammalian, Energy Metabolism, HEK293 Cells, Humans, Receptor Activity-Modifying Proteins, Receptor, Melanocortin, Type 4, Zebrafish, Zebrafish Proteins, alpha-MSH
Added May 27, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.
Ghamari-Langroudi M, Srisai D, Cone RD
(2011) Proc Natl Acad Sci U S A 108: 355-60
MeSH Terms: Animals, Arcuate Nucleus of Hypothalamus, Electrophysiology, Energy Metabolism, Green Fluorescent Proteins, Homeostasis, Immunohistochemistry, Leptin, Melanocortins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Neurons, Neuropeptide Y, Paraventricular Hypothalamic Nucleus, Polymerase Chain Reaction, Receptor, Melanocortin, Type 4, Signal Transduction, alpha-MSH
Added December 10, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.
Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD
(2010) Mol Endocrinol 24: 2366-81
MeSH Terms: Adiposity, Animals, Arcuate Nucleus of Hypothalamus, Fasting, Humans, Hypothalamo-Hypophyseal System, Leptin, Melanocortins, Mice, Mice, Transgenic, Neurons, Neuropeptide Y, Paraventricular Hypothalamic Nucleus, Pituitary Gland, Rats, Thyroid Gland, Thyroid Hormones, Thyrotropin-Releasing Hormone, alpha-MSH
Added December 10, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
Conserved neurochemical pathways involved in hypothalamic control of energy homeostasis.
Forlano PM, Cone RD
(2007) J Comp Neurol 505: 235-48
MeSH Terms: Agouti-Related Protein, Animals, Biological Evolution, Energy Metabolism, Female, Homeostasis, Hypothalamus, Immunohistochemistry, Larva, Male, Neural Pathways, Phylogeny, Zebrafish, alpha-MSH
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones.
Ni XP, Butler AA, Cone RD, Humphreys MH
(2006) J Hypertens 24: 2239-46
MeSH Terms: Amiloride, Animals, Blood Pressure, Dose-Response Relationship, Drug, Heart Rate, Hypertension, Mice, Mice, Knockout, Models, Animal, Receptor, Melanocortin, Type 3, Receptor, Melanocortin, Type 4, Sodium Channel Blockers, Sympatholytics, alpha-MSH, gamma-MSH
Added December 10, 2013
0 Communities
1 Members
0 Resources
15 MeSH Terms
Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression.
Morgan C, Cone RD
(2006) Behav Genet 36: 291-300
MeSH Terms: Aggression, Agonistic Behavior, Animals, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Pheromones, Receptors, Corticotropin, Receptors, Melanocortin, alpha-MSH
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Anatomy and regulation of the central melanocortin system.
Cone RD
(2005) Nat Neurosci 8: 571-8
MeSH Terms: Adipose Tissue, Animals, Appetite Regulation, Arcuate Nucleus of Hypothalamus, Brain Stem, Energy Metabolism, Humans, Neural Pathways, Neuropeptides, Receptors, Melanocortin, Signal Transduction, alpha-MSH
Added December 10, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms