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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease.
Vanderburgh JP, Kwakwa KA, Werfel TA, Merkel AR, Gupta MK, Johnson RW, Guelcher SA, Duvall CL, Rhoades JA
(2019) J Control Release 311-312: 257-272
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Drug Carriers, Drug Liberation, Female, Gene Expression Regulation, Neoplastic, Humans, Mammary Neoplasms, Animal, Mesenchymal Stem Cells, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Nanoparticles, Osteogenesis, Polymers, Pyridines, Thiophenes, Zinc Finger Protein Gli2
Added March 3, 2020
0 Communities
4 Members
0 Resources
23 MeSH Terms
Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma.
Cannonier SA, Gonzales CB, Ely K, Guelcher SA, Sterling JA
(2016) Oncotarget 7: 76062-76075
MeSH Terms: Animals, Bone and Bones, Carcinoma, Squamous Cell, Cell Line, Tumor, Disease Models, Animal, Gene Expression, Hedgehog Proteins, Heterografts, Humans, Mice, Mouth Neoplasms, Neoplasm Invasiveness, Nuclear Proteins, Parathyroid Hormone-Related Protein, Signal Transduction, Transforming Growth Factor beta, Zinc Finger Protein Gli2
Added April 26, 2017
0 Communities
2 Members
0 Resources
17 MeSH Terms
Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II.
Page JM, Merkel AR, Ruppender NS, Guo R, Dadwal UC, Cannonier S, Basu S, Guelcher SA, Sterling JA
(2015) Biomaterials 64: 33-44
MeSH Terms: Adenocarcinoma, Animals, Bone Neoplasms, Breast Neoplasms, Carcinoma, Squamous Cell, Cell Line, Tumor, Elastic Modulus, Extracellular Matrix, Female, Gene Expression Regulation, Neoplastic, Humans, Integrin beta3, Kruppel-Like Transcription Factors, Lung Neoplasms, Mice, Mice, Nude, Neoplasm Proteins, Nuclear Proteins, Osteolysis, Pliability, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Transfection, Transforming Growth Factor beta, Tumor Microenvironment, Xenograft Model Antitumor Assays, Zinc Finger Protein Gli2
Added February 23, 2016
1 Communities
2 Members
0 Resources
28 MeSH Terms
Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer.
Johnson RW, Merkel AR, Page JM, Ruppender NS, Guelcher SA, Sterling JA
(2014) Clin Exp Metastasis 31: 945-59
MeSH Terms: Animals, Blotting, Western, Bone Neoplasms, Breast Neoplasms, Female, Gene Expression Regulation, Humans, Kruppel-Like Transcription Factors, Lung Neoplasms, Mice, Mice, Nude, Nuclear Proteins, Parathyroid Hormone-Related Protein, Promoter Regions, Genetic, RNA, Messenger, RNA, Small Interfering, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Stromal Cells, Transforming Growth Factor beta, Tumor Cells, Cultured, Wnt3A Protein, Xenograft Model Antitumor Assays, Zinc Finger Protein Gli2, beta Catenin
Added February 12, 2015
1 Communities
3 Members
0 Resources
26 MeSH Terms
Cytogenetic prognostication within medulloblastoma subgroups.
Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Bourdeaut F, Delattre O, Doz FF, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD
(2014) J Clin Oncol 32: 886-96
MeSH Terms: Adolescent, Biomarkers, Tumor, Child, Child, Preschool, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Cytogenetics, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hedgehog Proteins, Humans, In Situ Hybridization, Fluorescence, Infant, Kruppel-Like Transcription Factors, Male, Medulloblastoma, Nuclear Proteins, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins c-myc, Reproducibility of Results, Risk Assessment, Risk Factors, Tissue Array Analysis, Wnt Proteins, Young Adult, Zinc Finger Protein Gli2
Added March 21, 2014
0 Communities
1 Members
0 Resources
29 MeSH Terms
6-Thioguanine inhibition of parathyroid hormone-related protein expression is mediated by GLI2.
Johnson RW, Merkel AR, Danilin S, Nguyen MP, Mundy GR, Sterling JA
(2011) Anticancer Res 31: 2705-12
MeSH Terms: Cell Line, Tumor, Cell Proliferation, Humans, Kruppel-Like Transcription Factors, Nuclear Proteins, Parathyroid Hormone-Related Protein, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Thioguanine, Zinc Finger Protein Gli2
Added March 12, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
Bone structural components regulating sites of tumor metastasis.
Sterling JA, Guelcher SA
(2011) Curr Osteoporos Rep 9: 89-95
MeSH Terms: Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Bone Density Conservation Agents, Bone Neoplasms, Breast Neoplasms, Denosumab, Diphosphonates, Female, Humans, Kruppel-Like Transcription Factors, Male, Nuclear Proteins, Parathyroid Hormone-Related Protein, RANK Ligand, Transforming Growth Factor beta, Zinc Finger Protein Gli2, rho-Associated Kinases
Added March 5, 2014
1 Communities
2 Members
0 Resources
17 MeSH Terms
TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.
Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR, Sterling JA
(2011) Cancer Res 71: 822-31
MeSH Terms: Animals, Bone Neoplasms, Breast Neoplasms, Female, Hedgehog Proteins, Humans, Kruppel-Like Transcription Factors, Mice, Mice, Nude, Nuclear Proteins, Parathyroid Hormone-Related Protein, Recombinant Proteins, Signal Transduction, Transforming Growth Factor beta, Veratrum Alkaloids, Zinc Finger Protein Gli2
Added March 5, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
An essential role for dermal primary cilia in hair follicle morphogenesis.
Lehman JM, Laag E, Michaud EJ, Yoder BK
(2009) J Invest Dermatol 129: 438-48
MeSH Terms: Animals, Cilia, Dermis, Hair Follicle, Hedgehog Proteins, Hypotrichosis, Integrases, Kruppel-Like Transcription Factors, Mice, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Signal Transduction, Wnt Proteins, Zinc Finger Protein Gli2
Added March 31, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells.
Sterling JA, Oyajobi BO, Grubbs B, Padalecki SS, Munoz SA, Gupta A, Story B, Zhao M, Mundy GR
(2006) Cancer Res 66: 7548-53
MeSH Terms: Animals, Breast Neoplasms, Cell Growth Processes, Cell Line, Tumor, Culture Media, Conditioned, Humans, Kruppel-Like Transcription Factors, Mice, Mice, Nude, Neoplasm Metastasis, Nuclear Proteins, Osteolysis, Parathyroid Hormone-Related Protein, Promoter Regions, Genetic, Radiography, Transfection, Zinc Finger Protein Gli2
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms