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Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells.
Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P
(2011) Gastroenterology 141: 2140-53
MeSH Terms: Anoikis, Cadherins, Cell Line, Tumor, Claudin-1, Colonic Neoplasms, Disease Progression, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Immunoblotting, Membrane Proteins, Microarray Analysis, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Transcription Factors, Up-Regulation, Zinc Finger E-box-Binding Homeobox 1
Added June 14, 2013
2 Communities
3 Members
0 Resources
18 MeSH Terms
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.
Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, Alder H, Liu CG, Dejean A, Croce CM
(2011) J Exp Med 208: 875-83
MeSH Terms: Carcinoma, Hepatocellular, Epithelial-Mesenchymal Transition, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hep G2 Cells, Homeodomain Proteins, Humans, Liver Neoplasms, Male, MicroRNAs, Neoplasm Metastasis, RNA, Neoplasm, Repressor Proteins, Transcription Factors, Transcriptional Activation, Tumor Suppressor Protein p53, Zinc Finger E-box Binding Homeobox 2, Zinc Finger E-box-Binding Homeobox 1
Added December 22, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
ZEB1-responsive genes in non-small cell lung cancer.
Gemmill RM, Roche J, Potiron VA, Nasarre P, Mitas M, Coldren CD, Helfrich BA, Garrett-Mayer E, Bunn PA, Drabkin HA
(2011) Cancer Lett 300: 66-78
MeSH Terms: Blotting, Western, Cadherins, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Epithelial-Mesenchymal Transition, Homeodomain Proteins, Humans, Lung Neoplasms, Repressor Proteins, Reverse Transcriptase Polymerase Chain Reaction, Serine Endopeptidases, Transcription Factors, Zinc Finger E-box Binding Homeobox 2, Zinc Finger E-box-Binding Homeobox 1
Added November 17, 2011
0 Communities
1 Members
0 Resources
14 MeSH Terms
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer.
Yang L, Amann JM, Kikuchi T, Porta R, Guix M, Gonzalez A, Park KH, Billheimer D, Arteaga CL, Tai HH, DuBois R, Carbone DP, Johnson DH
(2007) Cancer Res 67: 5587-93
MeSH Terms: Animals, Blotting, Western, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Electrophoretic Mobility Shift Assay, Epigenesis, Genetic, ErbB Receptors, Extracellular Signal-Regulated MAP Kinases, Gene Expression, Homeodomain Proteins, Humans, Hydroxyprostaglandin Dehydrogenases, Lung Neoplasms, Oligonucleotide Array Sequence Analysis, Protein Kinase Inhibitors, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Snail Family Transcription Factors, Transcription Factors, Transcription, Genetic, Zinc Finger E-box-Binding Homeobox 1
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, Helfrich B, Dziadziuszko R, Chan DC, Sugita M, Chan Z, Baron A, Franklin W, Drabkin HA, Girard L, Gazdar AF, Minna JD, Bunn PA
(2006) Cancer Res 66: 944-50
MeSH Terms: Antineoplastic Agents, Biomarkers, Tumor, Cadherins, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Disease Progression, Drug Resistance, Neoplasm, ErbB Receptors, Gefitinib, Histone Deacetylase Inhibitors, Homeodomain Proteins, Humans, Lung Neoplasms, Predictive Value of Tests, Prognosis, Quinazolines, Transcription Factors, Transfection, Zinc Finger E-box-Binding Homeobox 1
Added November 17, 2011
0 Communities
1 Members
0 Resources
19 MeSH Terms