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The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
(2021) Nat Commun 12: 5263
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Casein Kinase Ialpha, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Evolution, Molecular, HEK293 Cells, Humans, Immunologic Factors, Lenalidomide, Mice, Organoids, Peptide Hydrolases, Ubiquitin-Protein Ligases, Ubiquitination, Wnt Signaling Pathway, Zebrafish, Zebrafish Proteins
Added September 11, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA
(2021) Diabetologia 64: 850-864
MeSH Terms: Animals, Biomarkers, Blood Glucose, Female, Follicle Stimulating Hormone, Genotype, Homeostasis, Humans, Insulin, Insulin-Secreting Cells, Male, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Pituitary Gland, Sex Characteristics, Weight Gain, Zebrafish, Zebrafish Proteins
Added June 14, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
Systematic genome editing of the genes spanning an entire chromosome by CRISPR/Cas9 in a vertebrate-zebrafish (Danio rerio).
Gong Y, Yang B, Chen W
(2020) Sci China Life Sci 63: 1096-1097
MeSH Terms: Animals, Animals, Genetically Modified, Base Sequence, CRISPR-Associated Protein 9, CRISPR-Cas Systems, Chromosomes, Databases, Genetic, Gene Editing, Genome, Transcriptome, Zebrafish, Zebrafish Proteins
Added September 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.
Unlu G, Qi X, Gamazon ER, Melville DB, Patel N, Rushing AR, Hashem M, Al-Faifi A, Chen R, Li B, Cox NJ, Alkuraya FS, Knapik EW
(2020) Nat Med 26: 98-109
MeSH Terms: Abnormalities, Multiple, Animals, Behavior, Animal, Biological Specimen Banks, Chondrocytes, Disease Models, Animal, Extracellular Matrix, Fibroblasts, Guanine Nucleotide Exchange Factors, Humans, Models, Biological, Musculoskeletal System, Osteogenesis, Phenomics, Phenotype, Procollagen, Protein Transport, Secretory Pathway, Syndrome, Zebrafish, Zebrafish Proteins
Added January 15, 2020
0 Communities
1 Members
0 Resources
21 MeSH Terms
Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair.
Xie S, Fu W, Yu G, Hu X, Lai KS, Peng X, Zhou Y, Zhu X, Christov P, Sawyer L, Ni TT, Sulikowski GA, Yang Z, Lee E, Zeng C, Wang WE, Zhong TP
(2020) J Mol Cell Biol 12: 42-54
MeSH Terms: Animals, Animals, Genetically Modified, Cell Differentiation, Cell Line, Cell Proliferation, Disease Models, Animal, Heart Injuries, Male, Mice, Mice, Inbred C57BL, Mouse Embryonic Stem Cells, Myocardial Infarction, Myocytes, Cardiac, Regenerative Medicine, Signal Transduction, Small Molecule Libraries, Wnt Proteins, Wnt Signaling Pathway, Wound Healing, Zebrafish, Zebrafish Proteins, beta Catenin
Added April 10, 2019
0 Communities
1 Members
0 Resources
22 MeSH Terms
Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model.
Fleming JT, Brignola E, Chen L, Guo Y, Zhao S, Wang Q, Li B, Correa H, Ermilov AN, Dlugosz AA, Chiang C
(2019) Mol Cancer Res 17: 1024-1035
MeSH Terms: Animals, Gene Expression Regulation, Neoplastic, Hedgehog Proteins, Homeobox Protein Nkx-2.2, Homeodomain Proteins, Humans, Mice, Neoplasm Transplantation, Nerve Tissue Proteins, Nuclear Proteins, Sarcoma, Ewing, Signal Transduction, Transcription Factors, Zebrafish Proteins, Zinc Finger Protein Gli3
Added April 10, 2019
0 Communities
1 Members
0 Resources
15 MeSH Terms
Lef1-dependent hypothalamic neurogenesis inhibits anxiety.
Xie Y, Kaufmann D, Moulton MJ, Panahi S, Gaynes JA, Watters HN, Zhou D, Xue HH, Fung CM, Levine EM, Letsou A, Brennan KC, Dorsky RI
(2017) PLoS Biol 15: e2002257
MeSH Terms: Animals, Anxiety, Behavior, Animal, Biomarkers, Drosophila Proteins, Drosophila melanogaster, Female, Gene Expression Regulation, Genes, Reporter, Humans, Hypothalamus, Lymphoid Enhancer-Binding Factor 1, Male, Mice, Knockout, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Neurogenesis, Neurons, Species Specificity, Transcription Factors, Zebrafish, Zebrafish Proteins
Added February 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC
(2017) Cell Metab 25: 1362-1373.e5
MeSH Terms: Amino Acid Transport Systems, Neutral, Animals, Cell Proliferation, Glucagon, Glutamine, Liver, Mice, Mice, Knockout, Signal Transduction, Zebrafish, Zebrafish Proteins
Added September 21, 2018
0 Communities
4 Members
0 Resources
MeSH Terms
A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies.
Jao LE, Akef A, Wente SR
(2017) Mol Biol Cell 28: 120-127
MeSH Terms: Active Transport, Cell Nucleus, Adenosine Triphosphatases, Antigens, Basal Bodies, Centrosome, DEAD-box RNA Helicases, Nuclear Pore, Nuclear Pore Complex Proteins, Nucleocytoplasmic Transport Proteins, Protein Binding, RNA Transport, RNA, Messenger, RNA-Binding Proteins, Zebrafish Proteins
Added April 14, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.
Sasaki T, Lian S, Khan A, Llop JR, Samuelson AV, Chen W, Klionsky DJ, Kishi S
(2017) Autophagy 13: 386-403
MeSH Terms: Animals, Autophagy, Base Sequence, Biomarkers, CRISPR-Cas Systems, Cellular Senescence, Embryo, Nonmammalian, Gene Expression Regulation, Developmental, Gene Knockdown Techniques, Longevity, Lysosomes, Membrane Fusion, Membrane Proteins, Phagosomes, Proton-Translocating ATPases, Survival Analysis, Vacuolar Proton-Translocating ATPases, Zebrafish, Zebrafish Proteins
Added September 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms