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Publication Record


General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.
Swithers SE, Baker CR, Davidson TL
(2009) Behav Neurosci 123: 772-80
MeSH Terms: Analysis of Variance, Animals, Body Weight, Diet, Energy Intake, Fabaceae, Feeding Behavior, Female, Glucose, Male, Random Allocation, Rats, Rats, Sprague-Dawley, Saccharin, Sweetening Agents, Thiazines, Time Factors, Weight Gain, Yogurt
Show Abstract · Added April 17, 2012
In an earlier work (S. E. Swithers & T. L. Davidson, 2008), rats provided with a fixed amount of a yogurt diet mixed with saccharin gained more weight and showed impaired caloric compensation relative to rats given the same amount of yogurt mixed with glucose. The present 4 experiments examined the generality of these findings and demonstrated that increased body weight gain was also demonstrated when animals consumed a yogurt diet sweetened with an alternative high-intensity sweetener (acesulfame potassium; AceK) as well as in animals given a saccharin-sweetened base diet (refried beans) that was calorically similar but nutritionally distinct from low-fat yogurt. These studies also extended earlier findings by showing that body weight differences persist after saccharin-sweetened diets are discontinued and following a shift to a diet sweetened with glucose. In addition, rats first exposed to a diet sweetened with glucose still gain additional weight when subsequently exposed to a saccharin-sweetened diet. The results of these experiments add support to the hypothesis that exposure to weak or nonpredictive relationships between sweet tastes and caloric consequences may lead to positive energy balance.
2009 APA, all rights reserved
0 Communities
1 Members
0 Resources
19 MeSH Terms
A comparison of intrinsic and extrinsic tracer methods for estimating calcium bioavailability to rats from dairy foods.
Buchowski MS, Sowizral KC, Lengemann FW, Van Campen D, Miller DD
(1989) J Nutr 119: 228-34
MeSH Terms: Animals, Bone and Bones, Calcium Radioisotopes, Calcium, Dietary, Cheese, Dairy Products, Goats, Male, Milk, Nutritive Value, Rats, Rats, Inbred Strains, Solubility, Tooth, Yogurt
Show Abstract · Added December 10, 2013
Dairy products doubly labeled with 45Ca and 47Ca were used to evaluate an extrinsic labeling procedure for calcium bioavailability determination. Nonfat milk, yogurt, and fresh cheese curd were prepared from caprine milk that was intrinsically labeled with 45Ca. The products were then labeled extrinsically with 47Ca and administered to rats by gavage. The 47Ca to 45Ca ratio in bone and teeth averaged about 1.00 with either milk, yogurt, or CaCl2, but the ratio was about 1.04 when dosed with cheese curd. Ca absorption, determined by whole-body counting of 47Ca, was lower (P less than 0.05) in cheese curd (59%) than in either milk (69%), yogurt (72%), or CaCl2 (72%). Expressed as percent of dose, the absorption of 47Ca was highly correlated with bone 47Ca (r = 0.973) and with bone 45Ca (r = 0.946). Correlation between tibia 47Ca and tibia 45Ca was r = 0.923. For the dairy products tested, our results indicated that extrinsic 47Ca was absorbed similarly to intrinsic 45Ca. Moreover, the percent of radioactive dose retained in bone appears to be a valid indicator of relative bioavailability of food Ca.
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1 Members
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15 MeSH Terms