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Results: 1 to 10 of 28

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Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications.
Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W
(2020) J Biol Chem 295: 833-849
MeSH Terms: Biocatalysis, Biotechnology, Cytochrome P-450 Enzyme System, Metabolic Engineering, Protein Engineering, Steroids, Substrate Specificity, Xenobiotics
Added March 3, 2020
0 Communities
1 Members
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8 MeSH Terms
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.
Guengerich FP
(2017) Chem Res Toxicol 30: 2-12
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Drug Interactions, Humans, Pharmaceutical Preparations, Xenobiotics
Added March 14, 2018
0 Communities
1 Members
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6 MeSH Terms
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals.
Rendic S, Guengerich FP
(2015) Chem Res Toxicol 28: 38-42
MeSH Terms: Biotransformation, Humans, Oxidoreductases, Xenobiotics
Added January 20, 2015
0 Communities
1 Members
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4 MeSH Terms
Streptomyces cytochromes P450: applications in drug metabolism.
Lamb DC, Waterman MR, Zhao B
(2013) Expert Opin Drug Metab Toxicol 9: 1279-94
MeSH Terms: Biotransformation, Cytochrome P-450 Enzyme System, Drug Evaluation, Preclinical, Drug-Related Side Effects and Adverse Reactions, Genomics, Humans, Inactivation, Metabolic, Streptomyces, Xenobiotics
Added March 7, 2014
0 Communities
1 Members
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9 MeSH Terms
The structural basis of HLA-associated drug hypersensitivity syndromes.
Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov DA
(2012) Immunol Rev 250: 158-66
MeSH Terms: Antigen-Presenting Cells, Autoantigens, Binding Sites, Drug Hypersensitivity, HLA Antigens, Humans, Ligands, Models, Molecular, Peptides, Protein Binding, Protein Conformation, Receptors, Antigen, T-Cell, Syndrome, T-Lymphocytes, Xenobiotics
Added March 30, 2020
0 Communities
1 Members
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MeSH Terms
Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia.
Chokkalingam AP, Metayer C, Scelo GA, Chang JS, Urayama KY, Aldrich MC, Guha N, Hansen HM, Dahl GV, Barcellos LF, Wiencke JK, Wiemels JL, Buffler PA
(2012) Cancer Causes Control 23: 1367-75
MeSH Terms: Adolescent, Biological Transport, California, Case-Control Studies, Child, Child, Preschool, Environmental Exposure, Female, Genotype, Humans, Infant, Infant, Newborn, Male, Pesticides, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Risk Factors, Xenobiotics
Added February 26, 2014
0 Communities
1 Members
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17 MeSH Terms
Transcriptional ontogeny of the developing liver.
Lee JS, Ward WO, Knapp G, Ren H, Vallanat B, Abbott B, Ho K, Karp SJ, Corton JC
(2012) BMC Genomics 13: 33
MeSH Terms: Animals, Cluster Analysis, Erythroid Cells, Female, Fetus, Gene Expression Profiling, Gene Expression Regulation, Developmental, Hematopoietic Stem Cells, Humans, Liver, Male, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins, Organ Specificity, Pancreas, Polypyrimidine Tract-Binding Protein, Pregnancy, Ribonucleoproteins, Transcription, Genetic, Wnt Signaling Pathway, Xenobiotics
Added May 22, 2014
0 Communities
1 Members
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22 MeSH Terms
Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.
Przybysz AJ, Choe KP, Roberts LJ, Strange K
(2009) Mech Ageing Dev 130: 357-69
MeSH Terms: Adaptation, Physiological, Age Factors, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cytoprotection, DNA-Binding Proteins, Dose-Response Relationship, Drug, Down-Regulation, Forkhead Transcription Factors, Gene Expression Profiling, Mutation, Naphthoquinones, Oligonucleotide Array Sequence Analysis, Oxidative Stress, RNA Interference, Signal Transduction, Transcription Factors, Transcriptional Activation, Xenobiotics
Added December 10, 2013
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20 MeSH Terms
Protein damage by reactive electrophiles: targets and consequences.
Liebler DC
(2008) Chem Res Toxicol 21: 117-28
MeSH Terms: Animals, Electrophoresis, Polyacrylamide Gel, Humans, Immunochemistry, Proteins, Proteomics, Signal Transduction, Xenobiotics
Added March 20, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations.
Yamazaki H, Okayama A, Imai N, Guengerich FP, Shimizu M
(2006) Xenobiotica 36: 1201-9
MeSH Terms: Adolescent, Adult, Aged, Alleles, Asian Continental Ancestry Group, Child, Child, Preschool, Cytochrome P-450 Enzyme System, European Continental Ancestry Group, Female, Gene Expression, Genotype, Humans, In Vitro Techniques, Japan, Male, Microsomes, Liver, Middle Aged, Oxidation-Reduction, Oxygenases, Xenobiotics
Added March 26, 2014
0 Communities
1 Members
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21 MeSH Terms